發(fā)布時(shí)間：2019-06-25 11:45

【摘要】：肌細(xì)胞因子(myokines)是由肌細(xì)胞合成和釋放,發(fā)揮自分泌、旁分泌或內(nèi)分泌功能的細(xì)胞因子及多肽類物質(zhì)。肌細(xì)胞因子可作用于骨骼肌自身及脂肪、肝臟、胰腺、骨骼等多種組織器官參與機(jī)體物質(zhì)和能量代謝并影響各組織器官的結(jié)構(gòu)和功能,從而在維持機(jī)體的生物學(xué)穩(wěn)態(tài)中發(fā)揮重要作用。目前已發(fā)現(xiàn)的肌細(xì)胞因子有數(shù)百種,其中鳶尾素(irisin)、肌聯(lián)素(myonectin)、肌肉抑制素(myostatin)、腦源性神經(jīng)營養(yǎng)因子(brain-derived neurotrophic factor,BDNF)等對(duì)機(jī)體糖脂及能量代謝起到重要作用。本文主要闡述上述幾種代謝相關(guān)性肌細(xì)胞因子的合成和分泌、生理作用、作用機(jī)制及潛在臨床應(yīng)用。
[Abstract]:Myosin is a cytokine and polypeptide substance that is synthesized and released by myoblasts, and plays an autocrine, paracrine or endocrine function. Cytokine can play an important role in the maintenance of the biological steady state of the body, such as skeletal muscle itself and various tissues and organs such as the fat, the liver, the pancreas, the bone and the like, and affect the structure and function of the organs of the tissues. There are hundreds of muscle cytokines that have been found, including irisin, myonectin, myostatin, and brain-derived neurotrophic factor (BDNF), which play an important role in the body glycolipid and energy metabolism. The synthesis and secretion, the physiological function, the mechanism of action and the potential clinical application of the above-mentioned metabolic-related muscle cytokines are described in this paper.
【作者單位】： 復(fù)旦大學(xué)附屬華山醫(yī)院內(nèi)分泌科;
【分類號(hào)】：R589

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本文編號(hào)：2505657