【摘要】：目的評(píng)估皮膚AGE無(wú)創(chuàng)檢測(cè)技術(shù)在糖尿病篩查中的應(yīng)用價(jià)值。方法選取208例T2DM患者和119名健康體檢者行體征檢查、生化檢測(cè),采用基于AGE光學(xué)檢測(cè)技術(shù)的糖尿病無(wú)創(chuàng)檢測(cè)儀(DM Scan)對(duì)受試者上臂皮膚組織中的AGE進(jìn)行無(wú)創(chuàng)檢測(cè),采用受試者工作特征(ROC)曲線評(píng)價(jià)其敏感性和特異性。結(jié)果≤30歲、30~50歲和≥50歲糖尿病患者AGE均高于健康受試者[(56.2±4.1)vs(71.3±8.4)AU、(62.0±5.9)vs(70.6±6.2)AU、(62.5±6.9)vs(75.8±8.4)AU](P0.01)。Pearson相關(guān)分析顯示,AGE與FPG(r=0.417,P0.01)和HbA_1c(r=0.500,P0.01)相關(guān)。多元回歸分析顯示,AGE值與糖尿病發(fā)病風(fēng)險(xiǎn)密切相關(guān)[OR1.322,95%CI(1.228,1.424),P0.01]。DM Scan檢測(cè)皮膚AGE的ROC為0.941[95%CI(0.917,0.965)],AGE切點(diǎn)65.00AU時(shí)對(duì)應(yīng)的敏感性為88.5%,特異性為89.9%。結(jié)論 DM Scan檢測(cè)皮膚AGE篩查T2DM有較高的敏感性和特異性,有望成為一種新的無(wú)創(chuàng)糖尿病篩查工具。
[Abstract]:Objective to evaluate the value of skin AGE noninvasive detection in diabetes mellitus screening. Methods 208 patients with T2DM and 119 healthy subjects were examined by physical sign and biochemical examination. (DM Scan), a diabetes noninvasive detector based on AGE optical detection technique, was used for noninvasive detection of AGE in the skin tissue of the upper arm of the subjects. The sensitivity and specificity of the subjects were evaluated by (ROC) curve. Results the AGE of diabetic patients 鈮，

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