【摘要】：目的探討老年2型糖尿病病人甲狀腺激素的變化,分析其臨床意義及相關(guān)危險因素。方法該病例-對照研究采用數(shù)字表法隨機入選到醫(yī)院就診的140例老年2型糖尿病(type 2 diabetes mellitus,T2DM)病人為病例組,同期體檢的147例非糖尿病健康老人為對照組,靜脈采血化驗促甲狀腺素(thyroid-stimulating hormone,TSH)、三碘甲狀腺原氨酸(triiodothyronine,T3)、四碘甲狀腺原氨酸(thyroxine,T4)、甲狀腺過氧化物酶抗體(anti-thyroid peroxidase antibody,TPOAb)、甲狀腺球蛋白抗體(anti-thyroglobulin antibody,TGAb)、促甲狀腺素受體抗體(thyroid-stimulating hormone receptor antibodies,TRAb),檢測甲狀腺彩超,選取以上檢查均正常者入選本研究。病例組還需化驗空腹血糖(fasting plasma glucose,FPG)、糖化血紅蛋白(glycosylated hemoglobin A1c,HbA1c),根據(jù)年齡、病程、FPG及HbA1c不同分為若干組分。比較病例組與對照組以及病例組各組間甲狀腺激素的變化,分析其相關(guān)危險因素。結(jié)果 (1)與對照組相比,病例組T3降低,差異有統(tǒng)計學意義(P0.05)。(2)隨著老年糖尿病病人年齡增長、病程延長、FPG及HbA1c的升高,病例組各組間T3呈下降趨勢,差異有統(tǒng)計學意義(P0.05)。(3)相關(guān)回歸分析顯示,病例組T3與年齡、病程、FPG、HbA1c呈線性負相關(guān)。病程、HbA1c是影響T3的獨立危險因素。結(jié)論老年糖尿病病人的T3已有不同程度的降低,糖尿病病人甲狀腺激素濃度的測定可反映其糖代謝紊亂程度。
[Abstract]:Objective to investigate the changes of thyroid hormone in elderly patients with type 2 diabetes mellitus (T2DM), and to analyze its clinical significance and related risk factors. Methods in this case-control study, 140 elderly patients with type 2 diabetes mellitus (type 2 diabetes mellitus,T2DM) were randomly selected as the case group by digital table method, and 147 healthy elderly patients without diabetes mellitus were selected as the control group at the same time. Intravenous blood samples were collected for thyrotropin (thyroid-stimulating hormone,TSH), triiodothyronine (triiodothyronine,T3), tetraiodothyronine (thyroxine,T4), thyroid peroxide antibody (anti-thyroid peroxidase antibody,TPOAb), Thyroglobulin antibody (anti-thyroglobulin antibody,TGAb), thyrotropin receptor antibody (thyroid-stimulating hormone receptor antibodies,TRAb), thyroid color Doppler ultrasound (CDU) were detected. Fasting blood glucose (fasting plasma glucose,FPG), glycosylated hemoglobin (glycosylated hemoglobin A1c, HbA1c) were also tested in the case group. FPG and HbA1c were divided into several groups according to age, course of disease, FPG and HbA1c. The changes of thyroid hormones between the case group and the control group and the case group were compared, and the related risk factors were analyzed. Results (1) compared with the control group, T3 in the case group was significantly lower than that in the control group (P 0.05). (2). With the increase of age, the course of disease and the increase of FPG and HbA1c in the elderly diabetic patients, T3 in the case group showed a downward trend. The difference was statistically significant (P 0.05). (3). Regression analysis showed that T3 was negatively correlated with age, course of disease and FPG,HbA1c in the case group. Course of disease, HbA1c is an independent risk factor affecting T3. Conclusion T3 in elderly diabetic patients has been decreased to varying degrees, and the determination of thyroid hormone concentration in diabetic patients can reflect the disorder of glucose metabolism.
【作者單位】： 北京老年醫(yī)院內(nèi)分泌科;首都醫(yī)科大學附屬北京同仁醫(yī)院內(nèi)分泌科;
【分類號】：R587.1

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