怒江州怒族中老年人群骨質(zhì)疏松患病率調(diào)查及相關(guān)影響因素的分析
發(fā)布時(shí)間：2019-04-23 17:42
【摘要】：目的:1.通過(guò)定量超聲技術(shù)測(cè)定云南省怒江州地區(qū)怒族中老年人群跟骨骨密度參數(shù),探討其變化規(guī)律。2.調(diào)查云南省怒江州怒族中老年人群骨質(zhì)疏松癥患病率,同時(shí)探討與其相關(guān)危險(xiǎn)因素。3.評(píng)價(jià)OSTA系統(tǒng)在怒江州怒族中老年人群骨質(zhì)疏松癥自我診斷及預(yù)測(cè)中的價(jià)值。4.測(cè)定云南省怒江州怒族中老年人群血清骨代謝標(biāo)志物,了解其變化規(guī)律并評(píng)價(jià)其在預(yù)測(cè)骨質(zhì)疏松發(fā)生方面的價(jià)值。方法:采用現(xiàn)代流行病學(xué)分層隨機(jī)抽樣法,于云南省怒江州福貢縣匹河怒族鄉(xiāng),選取當(dāng)?shù)嘏?0歲以上年齡人群,共140人,以10歲為一年齡組,測(cè)定其基本生理體征、跟骨骨密度,同時(shí)以問(wèn)卷的形式了解包括其日常生活、作息習(xí)慣、生育生產(chǎn)史等信息。選取以上受試者中108例進(jìn)行血清β-CTX、BGP、BALP、PINP測(cè)定。將所得數(shù)據(jù)用spss21.0進(jìn)行統(tǒng)計(jì)分析。結(jié)果:1.云南省怒江州怒族中老年人群女性群體SI值呈現(xiàn)逐年遞減趨勢(shì),60-69年齡段SI丟失率最高,達(dá)到16.63%,且有統(tǒng)計(jì)學(xué)意義,50-59、70-79歲年齡段及整體不同性別間SI值有差異且有統(tǒng)計(jì)學(xué)意義,男性SI值大于女性。2.整體人群OP患病率為100%,女性患病率為10.70%,男性為7.1%。男性女性患病率均隨年齡增加而身高。其中總體及女性60-69歲、70-79歲患病率高于其他年齡段。身高、OSTA指數(shù)、體重與T值、SI值、Z值呈正相關(guān);總體人群的年齡及女性產(chǎn)次與T值、Z值、SI值呈負(fù)相關(guān)。3.OSTA風(fēng)險(xiǎn)等級(jí)與該地區(qū)OP患病率呈正相關(guān),OSTA風(fēng)險(xiǎn)等級(jí)越高,則OP患病率也就更高。OSTA風(fēng)險(xiǎn)指數(shù)的ROC曲線下面積女性為0.875;總體的AUC為0.852。OSTA指數(shù)怒族中老年人群總體及女性人群在OP預(yù)測(cè)準(zhǔn)確性上價(jià)值較高,準(zhǔn)確性好。4.怒江州怒族中老年人群β-CTX、BGP與T值呈負(fù)相關(guān)關(guān)系;女性β-CTX、BGP、BALP與T值呈負(fù)相關(guān)。怒江州怒族女性中患OP人群BALP、BGP值大于未患人群。結(jié)論:1.云南省怒江州怒族中老年人群骨強(qiáng)度指數(shù)SI隨著年齡逐步降低,女性降低速度快于男性,女性SI丟失率在60-69歲達(dá)高峰,預(yù)防的重點(diǎn)應(yīng)位于此年齡層。2.云南省怒江州怒族中老年人群OP患病率低于全國(guó)水平;人群總體及女性患病高峰在60-69歲、70-79歲,并且與SI丟失高峰重合,男性患病率比較分散,提示應(yīng)按性別分別設(shè)立防治重點(diǎn)年齡段,以達(dá)到最好效果。3.云南省怒江州怒族中老年人群女性骨量與年齡、產(chǎn)次呈負(fù)相關(guān),與孕次、初潮年齡及絕經(jīng)年齡無(wú)相關(guān)關(guān)系;總體人群骨量與體重、身高呈正相關(guān)。經(jīng)常食用豆制品、出行時(shí)多選擇步行均能降低怒族OP發(fā)病率。4.在檢測(cè)條件極度缺乏時(shí),尤其對(duì)于怒江州怒族群體,OSTA系統(tǒng)是怒族進(jìn)行骨質(zhì)疏松自我檢測(cè)的良好工具。5.怒江州怒族中老年人群女性β-CTX、BGP、BALP與T值呈負(fù)相關(guān)關(guān)系;怒江州怒族中老年女性op主要為高骨轉(zhuǎn)換型,當(dāng)血BALP、BGP升高應(yīng)警惕骨松發(fā)生。
[Abstract]:Purpose: 1. Calcaneal bone mineral density (BMD) was measured by quantitative ultrasound technique in Nujiang Prefecture, Yunnan Province, and the changes of calcaneal bone mineral density were discussed. 2. To investigate the prevalence of osteoporosis in the middle-aged and elderly population of Nujiang Prefecture, Yunnan Province, and to explore the related risk factors. To evaluate the value of OSTA system in self-diagnosis and prediction of osteoporosis in Nujiang Nuzu middle-aged and elderly population. 4. The serum bone metabolism markers were determined in Nujiang nationality middle-aged and aged people in Nujiang Prefecture of Yunnan Province to understand their changes and evaluate their value in predicting the occurrence of osteoporosis. Methods: using modern epidemiological stratified random sampling method, 140 people over 40 years old were selected from Pinghe Nu Township, Fugong County, Nujiang Prefecture, Yunnan Province. The basic physiological signs were measured with 10 years old as one-year-old group. Calcaneal bone mineral density, including daily life, rest habits, birth and production history, and so on in the form of questionnaires. Serum 尾-CTX,BGP,BALP,PINP was measured in 108 of the above subjects. The data were analyzed by spss21.0. Results: 1. In Nujiang Prefecture, Yunnan Province, the SI value of female population in the middle-aged and old age groups was decreasing year by year, and the loss rate of SI was the highest in 60-69 age group, reaching 16.63%, and there was statistical significance. There were significant differences in SI values between the age group and the whole sex in 50-59, 70-79 years old, and the SI value of male was higher than that of female, and the SI value of male was higher than that of female. The prevalence of OP was 100% in the population, 10.70% in females and 7.1% in males. The prevalence rate of male and female all increased with age and height. The prevalence rate of 60 years old and 70 years old women was higher than that of other age groups. Height, OSTA index and weight were positively correlated with T value, SI value and Z value. There was a negative correlation between age and female labor and T value, Z value and SI value. 3. Osta risk grade was positively correlated with the prevalence of OP in this area, and the higher the risk grade of OSTA was, the higher the risk grade of Osta was. The prevalence of OP was also higher. The area under the ROC curve of Osta risk index was 0.875 for females. The overall AUC for the 0.852.OSTA index of the middle-aged and elderly Nu population and the female population in the OP prediction accuracy is higher, the accuracy is good. 4. There was a negative correlation between 尾-CTX,BGP and T value in Nujiang Nu nationality, and a negative correlation between 尾-CTX,BGP,BALP and T value in female. The value of BALP, BGP in Nujiang Nu nationality women with OP was higher than that in non-Nu nationality women. Conclusions: 1. The bone strength index (SI) of the middle-aged and old-aged population in Nujiang Prefecture of Yunnan Province decreased gradually with the age, and the rate of SI loss in female was higher than that in male, and the rate of loss of BMD in female reached the peak at the age of 60 to 69. The emphasis of prevention should be in this age group. The prevalence of OP was lower in the middle-aged and aged people of Nujiang nationality in Yunnan province than in the whole country. The prevalence peak of population and female was 60 / 69 years old and 70 / 79 years old, and coincided with the peak of SI loss. The male prevalence rate was dispersed, suggesting that the key age groups for prevention and control should be set up according to sex, in order to achieve the best effect. 3. There was a negative correlation between bone mass and age and birth, but no correlation between bone mass and pregnancy, menarche age and menopause age, but a positive correlation between bone mass and body weight and height in the population of Nujiang Prefecture, Yunnan Province. Frequent consumption of soy products, walking when traveling can reduce the incidence of OP in the Nu ethnic group. 4. When testing conditions are extremely lacking, especially for Nujiang Nu population, OSTA system is a good tool for self-detection of osteoporosis in Nujiang. 5. There was a negative correlation between 尾-CTX,BGP,BALP and T value in the middle-aged and old-aged women of Nujiang Nu nationality, and the op of Nujiang Nu nationality middle-aged and elderly women was mainly of high bone turnover type, so the occurrence of bone loosening should be alerted when the blood BALP,BGP increased.
【學(xué)位授予單位】：昆明醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R580
[Abstract]:Purpose: 1. Calcaneal bone mineral density (BMD) was measured by quantitative ultrasound technique in Nujiang Prefecture, Yunnan Province, and the changes of calcaneal bone mineral density were discussed. 2. To investigate the prevalence of osteoporosis in the middle-aged and elderly population of Nujiang Prefecture, Yunnan Province, and to explore the related risk factors. To evaluate the value of OSTA system in self-diagnosis and prediction of osteoporosis in Nujiang Nuzu middle-aged and elderly population. 4. The serum bone metabolism markers were determined in Nujiang nationality middle-aged and aged people in Nujiang Prefecture of Yunnan Province to understand their changes and evaluate their value in predicting the occurrence of osteoporosis. Methods: using modern epidemiological stratified random sampling method, 140 people over 40 years old were selected from Pinghe Nu Township, Fugong County, Nujiang Prefecture, Yunnan Province. The basic physiological signs were measured with 10 years old as one-year-old group. Calcaneal bone mineral density, including daily life, rest habits, birth and production history, and so on in the form of questionnaires. Serum 尾-CTX,BGP,BALP,PINP was measured in 108 of the above subjects. The data were analyzed by spss21.0. Results: 1. In Nujiang Prefecture, Yunnan Province, the SI value of female population in the middle-aged and old age groups was decreasing year by year, and the loss rate of SI was the highest in 60-69 age group, reaching 16.63%, and there was statistical significance. There were significant differences in SI values between the age group and the whole sex in 50-59, 70-79 years old, and the SI value of male was higher than that of female, and the SI value of male was higher than that of female. The prevalence of OP was 100% in the population, 10.70% in females and 7.1% in males. The prevalence rate of male and female all increased with age and height. The prevalence rate of 60 years old and 70 years old women was higher than that of other age groups. Height, OSTA index and weight were positively correlated with T value, SI value and Z value. There was a negative correlation between age and female labor and T value, Z value and SI value. 3. Osta risk grade was positively correlated with the prevalence of OP in this area, and the higher the risk grade of OSTA was, the higher the risk grade of Osta was. The prevalence of OP was also higher. The area under the ROC curve of Osta risk index was 0.875 for females. The overall AUC for the 0.852.OSTA index of the middle-aged and elderly Nu population and the female population in the OP prediction accuracy is higher, the accuracy is good. 4. There was a negative correlation between 尾-CTX,BGP and T value in Nujiang Nu nationality, and a negative correlation between 尾-CTX,BGP,BALP and T value in female. The value of BALP, BGP in Nujiang Nu nationality women with OP was higher than that in non-Nu nationality women. Conclusions: 1. The bone strength index (SI) of the middle-aged and old-aged population in Nujiang Prefecture of Yunnan Province decreased gradually with the age, and the rate of SI loss in female was higher than that in male, and the rate of loss of BMD in female reached the peak at the age of 60 to 69. The emphasis of prevention should be in this age group. The prevalence of OP was lower in the middle-aged and aged people of Nujiang nationality in Yunnan province than in the whole country. The prevalence peak of population and female was 60 / 69 years old and 70 / 79 years old, and coincided with the peak of SI loss. The male prevalence rate was dispersed, suggesting that the key age groups for prevention and control should be set up according to sex, in order to achieve the best effect. 3. There was a negative correlation between bone mass and age and birth, but no correlation between bone mass and pregnancy, menarche age and menopause age, but a positive correlation between bone mass and body weight and height in the population of Nujiang Prefecture, Yunnan Province. Frequent consumption of soy products, walking when traveling can reduce the incidence of OP in the Nu ethnic group. 4. When testing conditions are extremely lacking, especially for Nujiang Nu population, OSTA system is a good tool for self-detection of osteoporosis in Nujiang. 5. There was a negative correlation between 尾-CTX,BGP,BALP and T value in the middle-aged and old-aged women of Nujiang Nu nationality, and the op of Nujiang Nu nationality middle-aged and elderly women was mainly of high bone turnover type, so the occurrence of bone loosening should be alerted when the blood BALP,BGP increased.
【學(xué)位授予單位】：昆明醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R580
【參考文獻(xiàn)】
相關(guān)期刊論文 前10條
1 唐瀟瀟;朱凌云;常向云;鄒文婷;馮艷敏;王曉麗;孫侃;;定量超聲骨密度檢測(cè)法在骨量異常篩查中的應(yīng)用價(jià)值[J];中華實(shí)用診斷與治療雜志;2017年02期
2 林雪完;王娟;;雌激素和骨標(biāo)志物與絕經(jīng)后婦女骨質(zhì)疏松的關(guān)系[J];中國(guó)老年學(xué)雜志;2017年02期
3 陳吉;陳勇;張征石;錢紅兵;湯國(guó)慶;承彬;王勇;王卓;;骨質(zhì)疏松性椎體壓縮性骨折經(jīng)皮椎體后凸成形術(shù)中骨水泥滲漏原因回顧性分析[J];中華骨質(zhì)疏松和骨礦鹽疾病雜志;2017年01期
4 陳雄;郭虹;祝美術(shù);沈鋒;王懷云;郭文榮;李秋舉;林國(guó)兵;陳祥;;PVP結(jié)合應(yīng)用胸腰骶固定矯形器支具治療OVCF的療效[J];中外醫(yī)療;2016年36期
5 賀麗英;孫蘊(yùn);要文娟;潘克h，
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