【摘要】：目的:利用代謝組學方法鑒定中藥芪苓顆粒治療高尿酸血癥大鼠的療效及其安全性。方法:通過腺嘌呤灌胃及氧嗪酸鉀皮下注射建立高尿酸血癥模型,結(jié)合血清生化檢測數(shù)據(jù)及代謝組學檢測數(shù)據(jù),對中藥治療后的安全性進行評價。結(jié)果:建立了穩(wěn)定的高尿酸血癥模型。建立了穩(wěn)定的高尿酸血癥模型,中藥干預(yù)后比較,發(fā)現(xiàn)大鼠血清生化檢測中尿酸及低密度脂蛋白水平降低,代謝組學檢測中氨基酸、脂肪酸及糖類的代謝存在明顯差異。結(jié)論:驗證了中藥芪苓顆粒治療高尿酸血癥有明確的療效,證明其治療過程同時對糖脂的代謝還有著一定的促進作用,且不存在代謝臟器的損傷。結(jié)果:建立了穩(wěn)定的高尿酸血癥模型,中藥干預(yù)后比較,發(fā)現(xiàn)大鼠血清生化檢測中尿酸及低密度脂蛋白水平降低,代謝組學檢測中氨基酸、脂肪酸及糖類的代謝存在明顯差異。
[Abstract]:Objective: to evaluate the efficacy and safety of Qiling granule in the treatment of hyperuricemia in rats with hyperuricemia by metabonomics. Methods: the model of hyperuricemia was established by oral administration of adenine and hypodermic injection of potassium oxazinate. The safety of traditional Chinese medicine after treatment was evaluated by combining the serum biochemical data and metabonomics data. Results: a stable hyperuricemia model was established. A stable model of hyperuricemia was established. It was found that the levels of uric acid and low density lipoprotein (LDL) in serum biochemical assay of rats were lower than those of control group. The metabolism of amino acids, fatty acids and sugars was significantly different in metabonomics. Conclusion: the curative effect of Qiling granule on hyperuricemia was verified. It was proved that Qiling granule could promote the metabolism of glucose and lipid, and there was no damage of metabolic organs in the treatment of hyperuricemia. Results: a stable model of hyperuricemia was established. After intervention, the levels of uric acid and low density lipoprotein (LDL) in serum of rats were decreased, and the metabolism of amino acids, fatty acids and sugars were significantly different in metabonomics.
【作者單位】： 杭州市中醫(yī)院;杭州市富陽區(qū)中醫(yī)院;
【基金】：2014年杭州市衛(wèi)生科技重點項目(No.2014Z07)~~
【分類號】：R589.7

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