腫瘤壞死因子-α誘導蛋白-8樣分子-2在自身免疫疾病中的作用及意義
發(fā)布時間：2019-04-20 09:03
【摘要】：自身免疫疾病是機體對自身組織細胞產(chǎn)生異常免疫應答反應所導致的一類疾病,其確切發(fā)病機制仍未闡明。腫瘤壞死因子-α誘導蛋白-8樣分子-2(TIPE2)是一種新近發(fā)現(xiàn)的免疫負性調(diào)控因子,屬于腫瘤壞死因子-α誘導蛋白-8(TNFAIP8)家族成員。研究發(fā)現(xiàn),TIPE2在多種自身免疫疾病中發(fā)生異常改變,并與疾病嚴重程度、病情進展及預后轉(zhuǎn)歸等密切相關(guān),包括自身免疫性肝炎、原發(fā)性膽汁性肝硬化、重癥肌無力、系統(tǒng)性紅斑狼瘡等,提示TIPE2在自身免疫疾病的發(fā)病中可能具有重要作用。TIPE2表達的缺陷可通過引起自身反應性T淋巴細胞或巨噬細胞的高反應性或促炎細胞因子大量釋放入血,加重炎癥反應并誘導自身免疫疾病的發(fā)生;或通過打破免疫穩(wěn)態(tài)間接誘發(fā)自身免疫疾病。本文擬對TIPE2在自身免疫疾病中的作用與機制研究進展作一綜述。
[Abstract]:Autoimmune diseases are a kind of diseases caused by abnormal immune response to their own tissues and cells. The exact pathogenesis of autoimmune diseases has not been clarified. Tumor necrosis factor-偽 inducible protein-8-like molecule-2 (TIPE2) is a newly discovered immuno-negative regulatory factor, which belongs to the tumor necrosis factor-偽 inducible protein-8 (TNFAIP8) family. It has been found that TIPE2 has abnormal changes in a variety of autoimmune diseases and is closely related to the severity, progression and prognosis of the disease, including autoimmune hepatitis, primary biliary cirrhosis, myasthenia gravis, and so on, including autoimmune hepatitis, primary biliary cirrhosis, myasthenia gravis, and so on. Systemic lupus erythematosus, et al., suggest that TIPE2 may play an important role in the pathogenesis of autoimmune diseases. The deficiency of TIPE2 expression may be caused by the high reactivity of autoreactive T lymphocytes or macrophages or the release of pro-inflammatory cytokines into the blood. Aggravate the inflammatory reaction and induce the occurrence of autoimmune diseases; Or indirectly induce autoimmune disease by breaking immune homeostasis. This paper reviews the role and mechanism of TIPE2 in autoimmune diseases.
【作者單位】： 第二軍醫(yī)大學學員旅;第二軍醫(yī)大學長海醫(yī)院燒創(chuàng)傷中心;
【分類號】：R593.2
[Abstract]:Autoimmune diseases are a kind of diseases caused by abnormal immune response to their own tissues and cells. The exact pathogenesis of autoimmune diseases has not been clarified. Tumor necrosis factor-偽 inducible protein-8-like molecule-2 (TIPE2) is a newly discovered immuno-negative regulatory factor, which belongs to the tumor necrosis factor-偽 inducible protein-8 (TNFAIP8) family. It has been found that TIPE2 has abnormal changes in a variety of autoimmune diseases and is closely related to the severity, progression and prognosis of the disease, including autoimmune hepatitis, primary biliary cirrhosis, myasthenia gravis, and so on, including autoimmune hepatitis, primary biliary cirrhosis, myasthenia gravis, and so on. Systemic lupus erythematosus, et al., suggest that TIPE2 may play an important role in the pathogenesis of autoimmune diseases. The deficiency of TIPE2 expression may be caused by the high reactivity of autoreactive T lymphocytes or macrophages or the release of pro-inflammatory cytokines into the blood. Aggravate the inflammatory reaction and induce the occurrence of autoimmune diseases; Or indirectly induce autoimmune disease by breaking immune homeostasis. This paper reviews the role and mechanism of TIPE2 in autoimmune diseases.
【作者單位】： 第二軍醫(yī)大學學員旅;第二軍醫(yī)大學長海醫(yī)院燒創(chuàng)傷中心;
【分類號】：R593.2
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1 姚人騏;馬兵;;腫瘤壞死因子-α誘導蛋白-8樣分子-2在自身免疫疾病中的作用及意義[J];解放軍醫(yī)學雜志;2017年08期
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