發(fā)布時(shí)間：2019-04-20 09:03

【摘要】：自身免疫疾病是機(jī)體對(duì)自身組織細(xì)胞產(chǎn)生異常免疫應(yīng)答反應(yīng)所導(dǎo)致的一類疾病,其確切發(fā)病機(jī)制仍未闡明。腫瘤壞死因子-α誘導(dǎo)蛋白-8樣分子-2(TIPE2)是一種新近發(fā)現(xiàn)的免疫負(fù)性調(diào)控因子,屬于腫瘤壞死因子-α誘導(dǎo)蛋白-8(TNFAIP8)家族成員。研究發(fā)現(xiàn),TIPE2在多種自身免疫疾病中發(fā)生異常改變,并與疾病嚴(yán)重程度、病情進(jìn)展及預(yù)后轉(zhuǎn)歸等密切相關(guān),包括自身免疫性肝炎、原發(fā)性膽汁性肝硬化、重癥肌無(wú)力、系統(tǒng)性紅斑狼瘡等,提示TIPE2在自身免疫疾病的發(fā)病中可能具有重要作用。TIPE2表達(dá)的缺陷可通過(guò)引起自身反應(yīng)性T淋巴細(xì)胞或巨噬細(xì)胞的高反應(yīng)性或促炎細(xì)胞因子大量釋放入血,加重炎癥反應(yīng)并誘導(dǎo)自身免疫疾病的發(fā)生;或通過(guò)打破免疫穩(wěn)態(tài)間接誘發(fā)自身免疫疾病。本文擬對(duì)TIPE2在自身免疫疾病中的作用與機(jī)制研究進(jìn)展作一綜述。
[Abstract]:Autoimmune diseases are a kind of diseases caused by abnormal immune response to their own tissues and cells. The exact pathogenesis of autoimmune diseases has not been clarified. Tumor necrosis factor-偽 inducible protein-8-like molecule-2 (TIPE2) is a newly discovered immuno-negative regulatory factor, which belongs to the tumor necrosis factor-偽 inducible protein-8 (TNFAIP8) family. It has been found that TIPE2 has abnormal changes in a variety of autoimmune diseases and is closely related to the severity, progression and prognosis of the disease, including autoimmune hepatitis, primary biliary cirrhosis, myasthenia gravis, and so on, including autoimmune hepatitis, primary biliary cirrhosis, myasthenia gravis, and so on. Systemic lupus erythematosus, et al., suggest that TIPE2 may play an important role in the pathogenesis of autoimmune diseases. The deficiency of TIPE2 expression may be caused by the high reactivity of autoreactive T lymphocytes or macrophages or the release of pro-inflammatory cytokines into the blood. Aggravate the inflammatory reaction and induce the occurrence of autoimmune diseases; Or indirectly induce autoimmune disease by breaking immune homeostasis. This paper reviews the role and mechanism of TIPE2 in autoimmune diseases.
【作者單位】： 第二軍醫(yī)大學(xué)學(xué)員旅;第二軍醫(yī)大學(xué)長(zhǎng)海醫(yī)院燒創(chuàng)傷中心;
【分類號(hào)】：R593.2

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