老年類風(fēng)濕關(guān)節(jié)炎患者頸椎失穩(wěn)的影響因素
發(fā)布時間：2019-04-08 08:25
【摘要】：目的探討老年類風(fēng)濕關(guān)節(jié)炎(RA)患者頸椎失穩(wěn)的影響因素。方法老年RA患者394例,依據(jù)患者是否發(fā)生頸椎失穩(wěn)分為頸椎失穩(wěn)組(n=52)和對照組(n=342),對入組患者的臨床資料進(jìn)行單因素分析和多因素Logistic回歸分析。結(jié)果頸椎失穩(wěn)患者多為寰樞椎前后半脫位,下頸椎半脫位患者發(fā)生率最低。頸椎失穩(wěn)組體重指數(shù)(BMI)低、病程長、吸煙史長、外周關(guān)節(jié)骨破壞多、關(guān)節(jié)腫脹個數(shù)多、關(guān)節(jié)壓痛個數(shù)多、使用生物制劑、長期使用激素、健康評估問卷殘疾指數(shù)(HAQ-DI)高、DAS28高、類風(fēng)濕因子(RF)多、C反應(yīng)蛋白(CRP)多的比例較對照組更高(P0.05)。病程長、外周關(guān)節(jié)骨破壞多、長期使用激素是老年RA患者頸椎失穩(wěn)的獨(dú)立危險因素(P0.05)。結(jié)論病程長、外周關(guān)節(jié)骨破壞多、長期使用激素是老年RA患者頸椎失穩(wěn)的獨(dú)立危險因素,臨床上應(yīng)重視高�；颊�,給予早期干預(yù)和有效治療。
[Abstract]:Objective to investigate the influencing factors of cervical instability in elderly patients with rheumatoid arthritis (RA). Methods 394 elderly patients with RA were divided into two groups according to whether the patients had cervical instability (n = 52) and control group (n = 342). The clinical data of the patients in the group were analyzed by univariate analysis and multi-factor Logistic regression analysis. Results most of the patients with cervical instability were anterior and posterior subluxation of atlantoaxial vertebra, and the incidence of lower cervical subluxation was the lowest. In the unstable cervical vertebra group, the body mass index (BMI) is low, the course of disease is long, the smoking history is long, the peripheral joint bone is destroyed, the number of joint swelling is more, the number of joint tenderness is more, biological preparation, long-term use of hormone, The disability index (HAQ-DI), DAS28, rheumatoid factor (RF) and C-reactive protein (CRP) were higher in the health assessment questionnaire than those in the control group (P0.05). The long-term use of hormone was the independent risk factor of cervical instability in elderly patients with RA (P0.05). Conclusion long-term use of hormone is an independent risk factor of cervical instability in elderly patients with RA. High-risk patients should be paid attention to in clinic, early intervention and effective treatment should be paid attention to.
【作者單位】： 蘭州大學(xué)第一醫(yī)院風(fēng)濕免疫科;
【分類號】：R593.22
，
本文編號：2454433
[Abstract]:Objective to investigate the influencing factors of cervical instability in elderly patients with rheumatoid arthritis (RA). Methods 394 elderly patients with RA were divided into two groups according to whether the patients had cervical instability (n = 52) and control group (n = 342). The clinical data of the patients in the group were analyzed by univariate analysis and multi-factor Logistic regression analysis. Results most of the patients with cervical instability were anterior and posterior subluxation of atlantoaxial vertebra, and the incidence of lower cervical subluxation was the lowest. In the unstable cervical vertebra group, the body mass index (BMI) is low, the course of disease is long, the smoking history is long, the peripheral joint bone is destroyed, the number of joint swelling is more, the number of joint tenderness is more, biological preparation, long-term use of hormone, The disability index (HAQ-DI), DAS28, rheumatoid factor (RF) and C-reactive protein (CRP) were higher in the health assessment questionnaire than those in the control group (P0.05). The long-term use of hormone was the independent risk factor of cervical instability in elderly patients with RA (P0.05). Conclusion long-term use of hormone is an independent risk factor of cervical instability in elderly patients with RA. High-risk patients should be paid attention to in clinic, early intervention and effective treatment should be paid attention to.
【作者單位】： 蘭州大學(xué)第一醫(yī)院風(fēng)濕免疫科;
【分類號】：R593.22
，
本文編號：2454433
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