【摘要】：目的研究甘肅省成人骨密度的基本情況,了解骨質(zhì)疏松及骨量減少的患病情況,分析甘肅省成人骨質(zhì)疏松癥的相關(guān)因素。方法制定甘肅省城鄉(xiāng)居民骨質(zhì)疏松流行病學(xué)調(diào)查表,采用分層、整群、隨機(jī)的方法進(jìn)行抽樣,在甘肅省抽取7個(gè)市州作為調(diào)查點(diǎn),對(duì)每個(gè)調(diào)查點(diǎn)的成人(18-79歲)進(jìn)行抽樣調(diào)查。所有受調(diào)查者均填寫(xiě)骨質(zhì)疏松癥流行病學(xué)調(diào)查問(wèn)卷,并進(jìn)行身高、體重等一般檢查,骨密度檢查以及骨代謝相關(guān)指標(biāo)檢測(cè)。結(jié)果參與本次流行病學(xué)調(diào)查人數(shù)共13015例,納入統(tǒng)計(jì)分析的有效數(shù)據(jù)共12085例,有效率為92.85%。男性共5809例,女性共6276例。1.在甘肅省成人(18-79歲)OP患病率為5.28%,男性為4.07%,女性為6.41%;骨量減少患病率為18.28%,男性為18.50%,女性為18.83%;60歲以上人群總體OP患病率為11.42%,其中女性為15.49%,男性為7.98%;絕經(jīng)后女性O(shè)P患病率明顯高于未絕經(jīng)女性(9.63%VS 0.63%)。2.使用多因素Logistic回歸分析顯示:在女性中,絕經(jīng)10年以上者患OP的風(fēng)險(xiǎn)遠(yuǎn)高于絕經(jīng)時(shí)間少于10年者(OR=2.14,95%CI 1.16-3.95,p=0.015)。在男性和女性中都存在這樣的規(guī)律:和受教育程度為大專及以上人群相比,未接受教育的人群患病風(fēng)險(xiǎn)明顯增高(女性:OR=7.38,95%CI 3.67-109.21,p0.001;男性:OR=1.83,95%CI1.24-2.69,p0.001);與BMI≥30kg/m2的人群相比,BMI18.5 kg/m2的人群OP患病風(fēng)險(xiǎn)顯著增高(女性:OR=21.01,95%CI 3.67-109.21,p=0.001;男性:OR=16.01,95%CI5.31-48.24,p=0.031);飲酒使得調(diào)查對(duì)象OP患病風(fēng)險(xiǎn)增加(女性:OR=1.71,95%CI1.08-2.68,p=0.022;男性:OR=2.081,95%CI 1.43-3.02,p0.001);吸煙是男性O(shè)P的危險(xiǎn)因素(OR=2.79,95%CI 1.39-5.68,p=0.004);有既往骨折史者患病風(fēng)險(xiǎn)顯著高于沒(méi)有既往骨折史者(女性:OR=2.228,95%CI 1.35-3.67,p=0.002;男性:OR=1.04,95%CI 1.32-3.42,p=0.001)。規(guī)律補(bǔ)鈣在男女性中均是OP的保護(hù)性因素(女性:OR=0.55,95%CI 0.42-0.72,p0.001;男性:OR=0.37,95%CI 0.21-0.60,p=0.001);有規(guī)律鍛煉習(xí)慣的人群OP患病風(fēng)險(xiǎn)降低(女性:OR=0.61,95%CI 0.43-0.86,p=0.005;男性:OR=0.57,95%CI 0.41-0.78,p0.001)。3.通過(guò)對(duì)不同性別各年齡段的骨代謝相關(guān)指標(biāo)的分析顯示年齡是影響骨代謝相關(guān)指標(biāo)水平的因素。4.控制了年齡及絕經(jīng)年限之后的偏相關(guān)分析顯示:不論在男性還是女性中,OC(男性:r=-0.102,p=0.001;女性:r=-0.183,p0.001)和β-CTX(男性:r=-0.102,p=0.003;女性:r=-0.197,p0.001)與BMD均呈負(fù)相關(guān),Ca(r=0.185,p0.001)和P(r=0.261,p0.001)與BMD呈正相關(guān),但這一趨勢(shì)僅在男性中有統(tǒng)計(jì)學(xué)意義。結(jié)論甘肅省OP的患病率較全國(guó)其他地區(qū)略低,在50-59歲之后,患病率明顯升高,因此對(duì)于OP的預(yù)防重點(diǎn)應(yīng)在上述人群;經(jīng)常參加鍛煉、接受日照、規(guī)律補(bǔ)鈣、大的BMI和受教育程度較高是OP的保護(hù)性因素,吸煙、飲酒,既往骨折史使得OP患病風(fēng)險(xiǎn)增加;年齡是影響骨代謝相關(guān)指標(biāo)水平的因素。OC、β-CTX和BMD成負(fù)相關(guān),僅在男性中發(fā)現(xiàn)血清Ca和P與BMD成正相關(guān)。
[Abstract]:Aim to study the basic condition of bone mineral density (BMD) in adults in Gansu province, to understand the prevalence of osteoporosis and bone mass reduction, and to analyze the related factors of osteoporosis in adults in Gansu province. Methods the epidemiological questionnaire of osteoporosis among urban and rural residents in Gansu Province was established. Stratified, cluster and random sampling was carried out in 7 cities and prefectures of Gansu Province. A sample survey of adults (18 to 79 years old) at each survey site was conducted. All subjects filled in the osteoporosis epidemiological questionnaire, and carried out height, weight and other general tests, bone mineral density test and bone metabolism related indicators. Results 13015 cases participated in the epidemiological survey, 12085 cases were effective data, the effective rate was 92.85%. There are 5809 males and 6276 females. In Gansu Province, the prevalence of OP was 5.28%, 4.07% for males and 6.41% for females, 18.28% for males, 18.50% for males and 18.83% for females, respectively, and the prevalence rate of BMD was 18.28% for males, 18.50% for males and 18.83% for females. The prevalence of OP in postmenopausal women was significantly higher than that in non-menopausal women (9.63%VS 0.63%). The overall prevalence of OP was 11.42% in women over 60 years old, 15.49% in women and 7.98% in men, and significantly higher in postmenopausal women (9.63%VS 0.63%). Multivariate Logistic regression analysis showed that the risk of OP was significantly higher in women with menopause more than 10 years (OR=2.14,95%CI 1.16, 3.95, p < 0.015). The risk of OP was significantly higher in women with menopause than 10 years after menopause (OR=2.14,95%CI 1.16, 3.95, p < 0.015). There was a pattern in both men and women: uneducated people had a significantly higher risk than those with a higher education level (female: OR=7.38,95%CI 3.67 / 109.21, p 0.001); Compared with those with BMI 鈮，

本文編號(hào)：2451799