非布司他對(duì)慢性痛風(fēng)性關(guān)節(jié)炎中NALP3炎性體的作用及意義
發(fā)布時(shí)間：2019-03-04 21:43
【摘要】：目的探討非布司他治療慢性痛風(fēng)性關(guān)節(jié)炎及其對(duì)NALP3炎性體的影響。方法選取89例慢性痛風(fēng)性關(guān)節(jié)炎患者和50例健康體檢者,檢測(cè)各組治療前后NALP3炎性體mRNA及NALP3炎性體的蛋白表達(dá)水平。結(jié)果治療組治療前血尿酸、NALP3、ASC及Caspase-1 mRNA的表達(dá)較對(duì)照組高(P0.05)。苯溴馬隆與別嘌醇組治療前后NALP3炎性體無(wú)改變。非布司他組治療后血尿酸、NALP3 mRNA(P=0.040)和Caspase-1 mRNA(P=0.023)的表達(dá)明顯降低(P0.05),ASC mRNA的表達(dá)升高(P=0.043)。非布司他組治療前后比較差異有統(tǒng)計(jì)學(xué)意義。結(jié)論 NALP3炎性體與慢性痛風(fēng)性關(guān)節(jié)炎相關(guān),非布司他可以更好的降尿酸并影響其功能。
[Abstract]:Objective to investigate the effect of non-bustane on chronic gouty arthritis and NALP3 inflammation. Methods 89 patients with chronic gouty arthritis and 50 healthy controls were selected to detect the protein expression of mRNA and NALP3 in NALP3 inflammation body before and after treatment. Results the expression of serum uric acid, NALP3,ASC and Caspase-1 mRNA in the treatment group before treatment was higher than that in the control group (P0.05). There was no change in the inflammatory body of NALP3 before and after treatment in the groups of benzimarone and allopurinol. The expression of serum uric acid, NALP3 mRNA (P < 0. 040) and Caspase-1 mRNA (P < 0. 023) were significantly decreased in non-bustane group after treatment (P < 0. 05). The expression of), ASC mRNA was increased (P < 0. 043). There was significant difference between before and after treatment in non-bustane group. Conclusion NALP3 is associated with chronic gouty arthritis, and non-bustane can reduce uric acid and affect its function.
【作者單位】： 廣州醫(yī)科大學(xué)附屬第三醫(yī)院荔灣醫(yī)院風(fēng)濕科;廣東省醫(yī)學(xué)科學(xué)院 廣東省人民醫(yī)院風(fēng)濕科;
【基金】：廣東省科技廳科研基金項(xiàng)目(編號(hào):2016ZC0151)
【分類號(hào)】：R589.7
[Abstract]:Objective to investigate the effect of non-bustane on chronic gouty arthritis and NALP3 inflammation. Methods 89 patients with chronic gouty arthritis and 50 healthy controls were selected to detect the protein expression of mRNA and NALP3 in NALP3 inflammation body before and after treatment. Results the expression of serum uric acid, NALP3,ASC and Caspase-1 mRNA in the treatment group before treatment was higher than that in the control group (P0.05). There was no change in the inflammatory body of NALP3 before and after treatment in the groups of benzimarone and allopurinol. The expression of serum uric acid, NALP3 mRNA (P < 0. 040) and Caspase-1 mRNA (P < 0. 023) were significantly decreased in non-bustane group after treatment (P < 0. 05). The expression of), ASC mRNA was increased (P < 0. 043). There was significant difference between before and after treatment in non-bustane group. Conclusion NALP3 is associated with chronic gouty arthritis, and non-bustane can reduce uric acid and affect its function.
【作者單位】： 廣州醫(yī)科大學(xué)附屬第三醫(yī)院荔灣醫(yī)院風(fēng)濕科;廣東省醫(yī)學(xué)科學(xué)院 廣東省人民醫(yī)院風(fēng)濕科;
【基金】：廣東省科技廳科研基金項(xiàng)目(編號(hào):2016ZC0151)
【分類號(hào)】：R589.7
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