【摘要】：背景:痛風(fēng)(gout)是嘌呤代謝紊亂引起的代謝性疾病,但痛風(fēng)的發(fā)病因人而異,每個(gè)人的表現(xiàn)都不盡相同,除出現(xiàn)高尿酸血癥外,在臨床上還可表現(xiàn)為慢性關(guān)節(jié)炎、慢性間質(zhì)性腎炎、急性關(guān)節(jié)炎、關(guān)節(jié)畸形、泌尿系統(tǒng)的尿酸性結(jié)石和痛風(fēng)石。當(dāng)高尿酸血癥患者伴隨上述臨床癥狀時(shí),才能診斷為痛風(fēng)。治療一般有以下幾類藥:排UA藥、抑制UA生成藥、堿性藥物、秋水仙堿、非甾體抗炎藥、糖皮質(zhì)激素等。隨著對痛風(fēng)的進(jìn)一步了解,近幾年發(fā)現(xiàn)了一種新型的降尿酸藥物非布司他,為黃嘌呤氧化酶(XO)抑制劑,通過抑制黃嘌呤氧化酶減少UA的生成,從而起到降低UA的作用,適用于高尿酸血癥患者伴有痛風(fēng)癥狀的長期治療,不適合其用來治療單純性的高尿酸血癥。目的:通過綜合目前非布司他在治療痛風(fēng)方面的研究,從而為臨床上更好的治療痛風(fēng)提供一些參考。方法:以 非布司他、痛風(fēng)、高尿酸血癥‖等關(guān)鍵詞進(jìn)行檢索,找出非布司他治療痛風(fēng)的相關(guān)研究,同時(shí)對其他治療痛風(fēng)的藥物進(jìn)行總結(jié)。結(jié)果與結(jié)論:目前有大量有關(guān)非布司他及其他藥物治療痛風(fēng)的文獻(xiàn),綜合這些研究結(jié)果表明非布司他是目前治療有痛風(fēng)癥狀的高尿酸血癥的首選治療藥物,非布司他的副作用較其他藥物而言相對較小,在降尿酸方面目前是療效最好的藥物。
[Abstract]:Background: gout (gout) is a metabolic disease caused by purine metabolic disorder. However, the incidence of gout varies from person to person. In addition to hyperuricemia, gout is characterized by chronic arthritis. Chronic interstitial nephritis, acute arthritis, joint deformities, urinary acid stones and gout stones. Gout can only be diagnosed when hyperuricemia is accompanied by these clinical symptoms. Treatment generally has the following kinds of drugs: UA drugs, UA inhibitory drugs, alkaline drugs, colchicine, non-steroidal anti-inflammatory drugs, glucocorticoids and so on. With the further understanding of gout, in recent years, a new type of anti-uric acid drug, non-bustrast, has been discovered as a (XO) inhibitor of xanthine oxidase, which can reduce the production of UA by inhibiting xanthine oxidase, thus reducing the effect of UA. It is suitable for long-term treatment of hyperuricemia with gout symptoms and is not suitable for the treatment of simple hyperuricemia. Objective: to provide some references for better clinical treatment of gout by synthesizing the current research on the treatment of gout. Methods: to search for the key words of fenburestar, gout and hyperuricemia, to find out the related studies on the treatment of gout, and to summarize the other drugs for treating gout. Results & conclusion: there are a large number of literatures on the treatment of gout with non-buflast and other drugs. These results indicate that Festa is the first choice in the treatment of hyperuricemia with symptoms of gout. The side effects of non-busultan are relatively small compared with other drugs and are currently the most effective in reducing uric acid.
【學(xué)位授予單位】：南昌大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R589.7

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