發(fā)布時間：2018-12-22 08:06

【摘要】：目的通過觀察2型糖尿病患者血糖控制,以了解糖尿病血管并發(fā)癥及其相關危險因素之間有無差別,并進行回歸分析進一步明確糖尿病患者大血管與微血管并發(fā)癥相關危險因素的異同,以期指導臨床。方法將258例確診2型糖尿病的住院患者,根據(jù)入院血糖控制情況以糖化血紅蛋白(Hb A1c)7%為觀察組,Hb A1c≤7%為對照組。觀察兩組間大血管并發(fā)癥頸動脈內(nèi)-中膜厚度、微血管并發(fā)癥尿微量白蛋白/肌酐比值、空腹C肽、胰島素抵抗指數(shù)(HOMA-IR)、纖維蛋白單體、血清25羥維生素D3[25(OH)D3]、胱抑素C、C反應蛋白、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)、體重指數(shù)及患者年齡、發(fā)病時間等有無差異,并對大血管及微血管并發(fā)癥分別進行二分類Logistic回歸分析。結(jié)果兩組間血糖高低未見與相關炎癥指標有關,大血管及微血管并發(fā)癥差異無統(tǒng)計學意義,但HDL-C,LDL-C及C肽、HOMA-IR、年齡均差異有統(tǒng)計學意義(P=0.002、0.001、0.001、0.001、0.019)。微血管并發(fā)癥的二分類Logistic回歸分析提示與25(OH)D3、胱抑素C有關。二分類Logistic回歸分析提示大血管并發(fā)癥與低密度脂蛋白膽固醇、胱抑素C有關。結(jié)論胱抑素C對糖尿病大血管及微血管并發(fā)癥有預測意義�；颊邤z入足量維生素D對微血管并發(fā)癥及LDL-C的達標對大血管并發(fā)癥的控制與發(fā)生有積極意義。
[Abstract]:Objective to investigate whether there is a difference between diabetic vascular complications and related risk factors by observing the control of blood glucose in patients with type 2 diabetes. The risk factors related to macrovascular and microvascular complications in diabetic patients were further identified by regression analysis in order to guide clinical practice. Methods two hundred and fifty-eight inpatients with type 2 diabetes mellitus were divided into two groups: Hb A1c (7%) and Hb A1c 鈮，

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