【摘要】：目的探討血清Chemerin與T2DM合并大血管病變患者體脂參數(shù)、糖脂代謝的關系。方法(1)新診斷T2DM患者80例按照有無下肢血管病變分為單純T2DM組及T2DM合并下肢血管病變組,其中,T2DM合并下肢血管病變組再分為輕度亞組、中度亞組和重度亞組;另選取健康體檢者(NGT)20名。ELISA檢測各組血清Chemerin濃度、糖脂代謝參數(shù)和FIns等指標,穩(wěn)態(tài)模型評估胰島素抵抗指數(shù)(HOMA-IR),計算BMI和腰身比(WSR)。(2)將研究對象分為WSR≤0.55組和WSR0.55組,比較兩組Chemerin水平。結果 T2DM合并下肢管病變中、重度亞組BMI、WSR、2 hPG、TG、Chemerin水平高于NGT組;重度亞組FPG、2 hPG、HbA_1 c、HOMA-IR、TG高于中度亞組(P0.05)。WSR0.55組血清Chemerin水平高于WSR≤0.55組(P0.05)。(3)血清Chemerin水平與BMI、WSR、FPG、2 hPG、HbA_1c、HOMA-IR和TG呈正相關(r=0.386、0.393、0.298、0.388、0.387、0.391、0.175,P0.05);與HDL-C呈負相關(r=-0.386,P0.05);Logistic回歸分析顯示,BMI和下肢血管病變積分是血清Chemerin的獨立影響因素(P0.05),BMI、WSR、TG和Chemerin是下肢血管病變的獨立影響因素(P0.05)。結論 T2DM患者血清Chemerin水平升高,與IR、體脂分布、糖脂代謝相關,且隨著T2DM大血管病變程度的加重,Chemerin水平逐漸升高。
[Abstract]:Objective to investigate the relationship between serum Chemerin and T2DM with macroangiopathy. Methods (1) Eighty patients with newly diagnosed T2DM were divided into simple T2DM group and T2DM complicated with lower extremity vascular disease group according to the presence or absence of lower extremity vascular lesion. Among them, T2DM combined with lower extremity vascular disease group was subdivided into mild subgroup, moderate subgroup and severe subgroup. Serum Chemerin concentration, glucose and lipid metabolism parameters and FIns were measured by ELISA in 20 healthy subjects, and insulin resistance index (HOMA-IR) was evaluated by steady-state model. BMI and waistline ratio (WSR). (2) were divided into two groups: WSR 鈮，

本文編號：2384561