【摘要】：目的:觀察哮喘-COPD重疊綜合征(Asthma-COPD overlap syndrome,ACOS)機(jī)械通氣患者肺泡灌洗液(BALF)中肺表面活性物質(zhì)相關(guān)蛋白D(SP-D)及白介素-8(IL-8)的水平,探討其對(duì)ACOS機(jī)械通氣患者病情發(fā)展影響。方法:38例ACOS機(jī)械通氣患者根據(jù)入院第1天和第5天的APACHEⅡ評(píng)分變化,分為病情加重組(18例),及病情緩解組(20例),收集機(jī)械通氣1、5 d的肺泡灌洗液,測(cè)定BALF中SP-D、IL-8濃度,觀察不同預(yù)后患者BALF中SP-D、IL-8水平的差異。結(jié)果:病情緩解組BALF中SP-D含量逐漸上升,機(jī)械通氣5 d較1 d明顯升高(P0.05);與病情緩解組比較,病情加重組機(jī)械通氣1 d、5 d BALF中SP-D含量均明顯降低(P0.05)。病情緩解組BALF中IL-8含量逐漸下降,病情加重組BALF中IL-8含量逐漸上升(P0.05)。統(tǒng)計(jì)分析結(jié)果提示BALF中IL-8含量與APACHE II評(píng)分呈負(fù)相關(guān)(r為-0.44,P0.05);統(tǒng)計(jì)分析結(jié)果提示BALF中SP-D濃度與APACHE II評(píng)分也呈負(fù)相關(guān)(r為-0.32,P0.05)。結(jié)論:SP-D、IL-8在ACOS患者的發(fā)生發(fā)展中起重要的作用,BALF中SP-D、IL-8可作為ACOS機(jī)械通氣患者病情監(jiān)測(cè)和預(yù)后的參考指標(biāo)。
[Abstract]:Objective: to observe the levels of pulmonary surfactant associated protein D (SP-D) and interleukin-8 (IL-8) in alveolar lavage fluid (BALF) of patients with asthmatic COPD overlap syndrome (Asthma-COPD overlap syndrome,ACOS). Objective: to investigate the effect of ACOS on the development of patients with mechanical ventilation. Methods: according to the changes of APACHE 鈪，

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