【摘要】：目的:檢測(cè)糖尿病足(DF)患者血清中胰島素樣生長(zhǎng)因子1(IGF-1)、胰島素樣生長(zhǎng)因子結(jié)合蛋白3(IGFBP-3)和血漿蛋白的水平,探討重組人生長(zhǎng)激素(rhGH)對(duì)DF患者的治療作用。方法:選取DF患者(DF組,n=40)、糖尿病患者(DM組,n=40)和健康成年人(正常對(duì)照組,n=40)為研究對(duì)象。將DF組患者按照患者意愿分為rhGH治療組和常規(guī)治療組,每組各20例。rhGH治療組患者給予0.4IU·kg-1·d-1rhGH注射液,皮下注射,每個(gè)療程15d,2個(gè)療程間隔5d,總計(jì)3個(gè)療程;常規(guī)治療組患者給予同等劑量生理鹽水皮下注射。比較各組研究對(duì)象一般臨床資料、治療前后血清IGF-1和IGFBP-3水平、患者病情分級(jí)構(gòu)成、血漿蛋白總蛋白(TP)、轉(zhuǎn)鐵蛋白(TRF)、空腹血糖(FBG)水平及DF組患者和正常對(duì)照組研究對(duì)象rhGH治療有效率和創(chuàng)面愈合時(shí)間。結(jié)果:DF組患者血清IGF-1和IGFBP-3水平明顯低于DM組和正常對(duì)照組(P0.01);DM組患者血清IGF-1和IGFBP-3水平明顯低于正常對(duì)照組(P0.05)。rhGH治療組患者治療后血清IGF-1、IGFBP-3和血漿TP、TRF水平與治療前比較差異有統(tǒng)計(jì)學(xué)意義(P0.05),且均高于常規(guī)治療組治療后的相應(yīng)指標(biāo)(P0.05);DM組和正常對(duì)照組研究對(duì)象FBG水平比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。rhGH治療組患者有效率明顯高于常規(guī)治療組(P0.05)。結(jié)論:DF患者經(jīng)rhGH治療后有效率提高,適合臨床推廣。
[Abstract]:Objective: to detect the levels of insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3 (IGFBP-3) and plasma protein in (DF) patients with diabetic foot. To investigate the therapeutic effect of recombinant human growth hormone (rhGH) on patients with DF. Methods: DF patients (DF group, n = 40), diabetic patients (DM group, n = 40) and healthy adults (normal control group, n = 40) were selected as subjects. The patients in the DF group were divided into two groups according to the wishes of the patients: the rhGH treatment group and the routine treatment group with 20 cases in each group. The patients in the rhGH treatment group were given 0.4IU kg-1 d-1rhGH injection subcutaneously for 15 days and the interval between the two courses was 5 days. A total of 3 courses of treatment; The patients in the routine treatment group were subcutaneously injected with the same dose of normal saline. The clinical data of each group were compared, the serum IGF-1 and IGFBP-3 levels before and after treatment, the grade composition of the patient's condition, the plasma total protein (TP), transferrin (TRF), were compared. Fasting blood glucose (FBG) level and the effective rate and wound healing time of rhGH in DF group and normal control group. Results: the levels of serum IGF-1 and IGFBP-3 in DF group were significantly lower than those in DM group and normal control group (P0.01). The levels of serum IGF-1 and IGFBP-3 in DM group were significantly lower than those in normal control group (P0.05). The levels of serum IGF-1,IGFBP-3 and plasma TP,TRF in DM group were significantly lower than those before treatment (P0.05). All of them were higher than the corresponding indexes of the routine treatment group (P0.05). There was no significant difference in FBG level between DM group and normal control group (P0.05). The effective rate of). RhGH group was significantly higher than that of routine treatment group (P0.05). Conclusion: the effective rate of DF patients is improved after rhGH treatment, which is suitable for clinical application.
【作者單位】： 吉林省人民醫(yī)院內(nèi)分泌二科;
【基金】：吉林省科技廳科技發(fā)展計(jì)劃項(xiàng)目資助課題(20130413006GH)
【分類號(hào)】：R587.2

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 王傳力,張鋒,朱明偉;重組人生長(zhǎng)激素的臨床應(yīng)用[J];河北醫(yī)藥;2001年12期

2 孫國(guó)鳳;;重組人生長(zhǎng)激素促進(jìn)身高矮的健康人長(zhǎng)高[J];生物技術(shù)通報(bào);1988年04期

3 王德芬,陳風(fēng)生,陳培雄,陳家倫,張達(dá)青,郁忠勤;重組人生長(zhǎng)激素治療生長(zhǎng)激素缺乏性侏儒癥[J];中華內(nèi)分泌代謝雜志;1990年04期

4 邢遠(yuǎn)翔;;重組人生長(zhǎng)激素治療侏儒癥[J];醫(yī)學(xué)信息;1994年02期

5 江靜,王德芬;肥胖癥的重組人生長(zhǎng)激素治療探討[J];生物學(xué)雜志;1999年01期

6 付慶華;莫桂英;葉慧芳;尹彩紅;周柯;;慷舒靈生長(zhǎng)激素局部治療糖尿病足的臨床研究[J];中華全科醫(yī)學(xué);2008年07期

7 楊丹英;趙詠桔;;健康老年人生長(zhǎng)激素分泌的變化及重組人生長(zhǎng)激素應(yīng)用的研究[J];國(guó)外醫(yī)學(xué)(老年醫(yī)學(xué)分冊(cè));2008年04期

8 余葉蓉,潘惠茹,王德芬,沈永年,王慕逖,王志超,李雙慶,倪繼紅,葉軍,方俊敏,陳靜,張?chǎng)┮?梁藎忠;國(guó)產(chǎn)重組人生長(zhǎng)激素治療生長(zhǎng)激素缺乏癥的臨床研究[J];中華內(nèi)分泌代謝雜志;1999年02期

9 楊富明,劉威,童光志,胡志強(qiáng),劉恩重;重組人生長(zhǎng)激素基因細(xì)胞移植[J];立體定向和功能性神經(jīng)外科雜志;2001年03期

10 雷春濤;樊映川;張學(xué)東;;IGF-1系統(tǒng)與糖尿病視網(wǎng)膜病變的研究進(jìn)展[J];重慶醫(yī)學(xué);2007年15期

相關(guān)會(huì)議論文 前4條

1 馬艷芬;李萬(wàn)根;陳澍;;胰島素和IGF-1促進(jìn)成骨樣細(xì)胞增殖功能的實(shí)驗(yàn)研究[A];2008內(nèi)分泌代謝性疾病系列研討會(huì)暨中青年英文論壇論文匯編[C];2008年

2 顧仁駿;韓國(guó)輝;張萍;張帆;師天元;張紅亞;李文強(qiáng);郭新勝;;急性一氧化碳中毒后遲發(fā)性腦病患者血清S100b蛋白、GFAP、IGF-1水平及其臨床意義[A];中華醫(yī)學(xué)會(huì)第十三次全國(guó)神經(jīng)病學(xué)學(xué)術(shù)會(huì)議論文匯編[C];2010年

3 王文匯;張承薇;顏淑紅;;2型糖尿病Leptin、IGF-1及骨密度研究[A];中華醫(yī)學(xué)會(huì)第六次全國(guó)內(nèi)分泌學(xué)術(shù)會(huì)議論文匯編[C];2001年

4 劉聰;潘莉莉;李強(qiáng);張?jiān)佈?劉英敏;郭兌山;;2型糖尿病人血IGF-1及IGFBP-3與糖尿病視網(wǎng)膜病變的關(guān)系[A];中華醫(yī)學(xué)會(huì)第六次全國(guó)內(nèi)分泌學(xué)術(shù)會(huì)議論文匯編[C];2001年

相關(guān)碩士學(xué)位論文 前3條

1 丁嵐;新疆維吾爾族2型糖尿病視網(wǎng)膜病變與血清IGF-1水平的關(guān)系[D];新疆醫(yī)科大學(xué);2006年

2 林海;細(xì)胞因子VEGF、IGF-1與2型糖尿病視網(wǎng)膜病變的相關(guān)性研究[D];吉林大學(xué);2011年

3 許輝;羅格列酮鈉對(duì)糖尿病大鼠胰島表達(dá)IGF-1的作用[D];廣西醫(yī)科大學(xué);2007年

，

本文編號(hào)：2376963