冠心病合并代謝綜合征與促酰化蛋白受體C5L2相關(guān)性分析
發(fā)布時間：2018-12-06 13:00
【摘要】：目的：探討冠心病(CHD)合并代謝綜合征(MS)患者與促�；鞍资荏wC5L2相關(guān)性。方法：選取門診體檢及住院受試者共240例,其中正常對照組68例,CHD組56例,MS組60例,CHD合并MS組56例。測量受試者人體學(xué)指標及血生化指標,并用反轉(zhuǎn)錄及實時熒光定量PCR方法檢測C5L2 mRNA表達。組間計量資料(符合正態(tài)性及方差齊性檢驗)比較采用單因素方差分析,計數(shù)資料的比較采用χ2檢驗,因素間相關(guān)性分析采用Pearson線性相關(guān)分析和多元線性回歸分析。結(jié)果：四組間C5L2mRNA表達水平未見統(tǒng)計學(xué)差異(F=0.22,P=0.88)；按不同性別分別進行四組間的比較,也未見統(tǒng)計學(xué)差異(F男=0.26,P=0.86;F女=0.13,P=0.94)。在CHD合并MS組中,C5L2mRNA表達與腰圍(WC)(P=0.02)、腰臀比(WHR)(P=0.03)及C反應(yīng)蛋白(CRP)(P0.01)呈正相關(guān),與高密度脂蛋白膽固醇(HDL-C)呈負相關(guān)(P=0.04),相關(guān)系數(shù)分別為0.45、0.43、0.47及-0.41；其它組間未發(fā)現(xiàn)這種相關(guān)性(P0.05)；多元逐步回歸分析顯示CRP(P模型10.01,P模型20.01)、WC(P=0.03)及WHR(P=0.04)是CHD合并MS患者C5L2mRNA表達水平的相關(guān)因素。結(jié)論：CRP、WC及WHR是CHD合并MS患者C5L2mRNA表達水平的相關(guān)因素,在CHD合并MS疾病狀態(tài)下,C5L2可能參于了疾病的炎癥反應(yīng)及脂肪代謝過程,特別是內(nèi)臟脂肪代謝。
[Abstract]:Objective: to investigate the correlation between acylating protein receptor (C5L2) and (CHD) with metabolic syndrome (MS) in patients with coronary heart disease (CHD). Methods: a total of 240 outpatients were selected, including 68 normal control group, 56 CHD group, 60 MS group and 56 CHD combined with MS group. The human body index and blood biochemical index were measured, and the expression of C5L2 mRNA was detected by reverse transcription and real-time fluorescence quantitative PCR. One-factor ANOVA was used to compare the measurement data (consistent with normality and homogeneity test of variance), 蠂 ~ 2 test was used to compare counting data, and Pearson linear correlation analysis and multivariate linear regression analysis were used to analyze the correlation among factors. Results: there was no statistical difference in the expression of C5L2mRNA among the four groups (FG 0.22 P 0.88), and there was no statistical difference between the four groups according to sex (F male = 0.26 P 0.86 F = 0.13 P 0.94). In CHD combined with MS group, the expression of C5L2mRNA was positively correlated with the waist circumference (WC) (Pn0. 02), WHR (WHR) (P0. 03) and C-reactive protein (CRP) (P0. 01). There was a negative correlation between high density lipoprotein cholesterol (HDL-C) and high density lipoprotein cholesterol (P0. 04), and the correlation coefficients were 0. 45 and-0. 41, respectively. No such correlation was found among other groups (P0.05), and multiple stepwise regression analysis showed that CRP (P model 10.01), WC (P0. 03 and WHR (P0. 04) were the related factors of C5L2mRNA expression in CHD patients with MS. Conclusion: CRP,WC and WHR are related factors of C5L2mRNA expression in patients with CHD and MS. C5L2 may be involved in inflammatory reaction and fat metabolism, especially visceral fat metabolism, in the condition of CHD with MS disease.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R541.4;R589
，
本文編號：2366064
[Abstract]:Objective: to investigate the correlation between acylating protein receptor (C5L2) and (CHD) with metabolic syndrome (MS) in patients with coronary heart disease (CHD). Methods: a total of 240 outpatients were selected, including 68 normal control group, 56 CHD group, 60 MS group and 56 CHD combined with MS group. The human body index and blood biochemical index were measured, and the expression of C5L2 mRNA was detected by reverse transcription and real-time fluorescence quantitative PCR. One-factor ANOVA was used to compare the measurement data (consistent with normality and homogeneity test of variance), 蠂 ~ 2 test was used to compare counting data, and Pearson linear correlation analysis and multivariate linear regression analysis were used to analyze the correlation among factors. Results: there was no statistical difference in the expression of C5L2mRNA among the four groups (FG 0.22 P 0.88), and there was no statistical difference between the four groups according to sex (F male = 0.26 P 0.86 F = 0.13 P 0.94). In CHD combined with MS group, the expression of C5L2mRNA was positively correlated with the waist circumference (WC) (Pn0. 02), WHR (WHR) (P0. 03) and C-reactive protein (CRP) (P0. 01). There was a negative correlation between high density lipoprotein cholesterol (HDL-C) and high density lipoprotein cholesterol (P0. 04), and the correlation coefficients were 0. 45 and-0. 41, respectively. No such correlation was found among other groups (P0.05), and multiple stepwise regression analysis showed that CRP (P model 10.01), WC (P0. 03 and WHR (P0. 04) were the related factors of C5L2mRNA expression in CHD patients with MS. Conclusion: CRP,WC and WHR are related factors of C5L2mRNA expression in patients with CHD and MS. C5L2 may be involved in inflammatory reaction and fat metabolism, especially visceral fat metabolism, in the condition of CHD with MS disease.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R541.4;R589
，
本文編號：2366064
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