【摘要】：目的評(píng)價(jià)糖耐量正常(normal glucose tolerance,NGT)人群口服葡萄糖耐量試驗(yàn)(oral glucose tolerance test,OGTT)1 h血糖與胰島素敏感性和胰島β細(xì)胞功能的關(guān)系。方法收集101例NGT和76例糖耐量異常(impaired glucose tolerance,IGT)病人的臨床資料;測(cè)定OGTT各時(shí)間點(diǎn)的血漿葡萄糖和胰島素濃度;比較NGT 1 h血糖(1 hour postload plasma glucose,1-h PG)8.6 mmol/L組、NGT 1-h PG≥8.6 mmol/L組和IGT組的胰島素敏感性和胰島β細(xì)胞功能,分析OGTT 1-h PG與胰島素敏感性和胰島β細(xì)胞功能的關(guān)系。結(jié)果 NGT 1-h PG≥8.6 mmol/L組的空腹血糖、1-h PG、1-h胰島素及胰島素敏感指數(shù)(homeostasis model assessment of insulin resistance,HOMA-IR)均顯著高于NGT 1-h PG8.6 mmol/L組;NGT 1-h PG≥8.6 mmol/L組的Matsuda指數(shù)、胰島素分泌指數(shù)(ΔI3 0/ΔG3 0和ΔI6 0/ΔG6 0)均顯著低于NGT 1-h PG8.6 mmol/L組(P均0.05)。但NGT 1-h PG≥8.6mmol/L組的空腹血糖、空腹胰島素、1-h PG、1-h胰島素、HOMA-IR、Matsuda指數(shù)、ΔI3 0/ΔG3 0和ΔI6 0/ΔG6 0與IGT組比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P均0.05)。多元線性回歸分析顯示1-h PG與ΔI30/ΔG30、Matsuda指數(shù)呈線性負(fù)相關(guān)。結(jié)論在NGT人群中,OGTT 1-h PG≥8.6 mmol/L人群胰島素敏感性和胰島β細(xì)胞功能低于1-h PG8.6 mmol/L組,1-h PG與胰島素敏感性和胰島β細(xì)胞功能相關(guān)。提示在NGT人群中,1-h PG濃度可作為評(píng)價(jià)胰島素敏感性和胰島β細(xì)胞功能的簡(jiǎn)易指標(biāo)。
[Abstract]:Objective to evaluate the relationship between insulin sensitivity and islet 尾 cell function in oral glucose tolerance test (oral glucose tolerance test,OGTT) 1 h glucose test (oral glucose tolerance test,OGTT) in patients with normal glucose tolerance (normal glucose tolerance,NGT). Methods the clinical data of 101 patients with NGT and 76 patients with impaired glucose tolerance (impaired glucose tolerance,IGT) were collected and the plasma glucose and insulin concentrations at different time points of OGTT were measured. Insulin sensitivity and islet 尾 cell function were compared in NGT 1 h glucose (1 hour postload plasma glucose,1-h PG) 8.6 mmol/L group, NGT 1-h PG 鈮，

本文編號(hào)：2302583