甲狀腺良性大結(jié)節(jié)射頻和微波消融治療的近期安全性和有效性分析
發(fā)布時(shí)間：2018-10-21 16:07
【摘要】：目的探討甲狀腺良性大結(jié)節(jié)射頻消融(radiofrequency ablation,RFA)和微波消融(microwave ablation,MWA)治療的近期安全性和有效性。方法選取2016年6月至2017年2月我院采用超聲引導(dǎo)下RFA(13例)和MWA(21例)治療甲狀腺良性大結(jié)節(jié)的患者,隨訪觀察比較兩種消融術(shù)后甲狀腺功能、血清抗體指標(biāo)變化、并發(fā)癥和甲狀腺結(jié)節(jié)縮小率(volume reduction rate,VRR)。結(jié)果所有患者治療前后血清游離三碘甲腺原氨酸(free triiodothyronine,fT3)、游離甲狀腺素(free thyroxine,fT4)、促甲狀腺激素(thyroid stimulating hormone,TSH)、抗甲狀腺球蛋白抗體(anti-thyroglobulin antibodies,TG-Ab)及抗甲狀腺過(guò)氧化物酶抗體(thyroid peroxidase antibodies,TPO-Ab)差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。MWA組1例患者術(shù)后出現(xiàn)輕度聲音嘶啞,RFA組1例出現(xiàn)術(shù)中出血10 mL,余患者均未發(fā)生頸部瘢痕、術(shù)后感染、皮膚灼傷及氣管食管損傷等并發(fā)癥。消融后1天超聲造影顯示結(jié)節(jié)均無(wú)血供,呈低弱回聲;消融后1個(gè)月RFA組和MWA組VRR分別為23.8%和22.6%,兩者治療效果差異無(wú)統(tǒng)計(jì)學(xué)意義(P=0.127)。結(jié)論 RFA和MWA治療甲狀腺良性大結(jié)節(jié)安全有效且并發(fā)癥少,兩者近期治療效果無(wú)顯著差異。
[Abstract]:Objective to evaluate the safety and efficacy of radiofrequency ablation (radiofrequency ablation,RFA) and microwave ablation (microwave ablation,MWA) in benign thyroid nodules. Methods from June 2016 to February 2017, 13 patients with benign thyroid nodules were treated with RFA (13 cases) and MWA (21 cases) under ultrasound guidance. The changes of thyroid function and serum antibody were observed and compared after two kinds of ablation. Complications and reduction rate of thyroid nodules (volume reduction rate,VRR). Results there was no difference in serum free triiodothyronine (free triiodothyronine,fT3), free thyroxine (free thyroxine,fT4), thyrotropin (thyroid stimulating hormone,TSH), anti-thyroglobulin antibody (anti-thyroglobulin antibodies,TG-Ab) and anti-thyroid peroxidase antibody (thyroid peroxidase antibodies,TPO-Ab) in all patients before and after treatment. Statistical significance (P0.05). MWA group, 1 patient with mild hoarseness after operation, RFA group 1 patient with intraoperative bleeding more than 10 mL, patients did not develop cervical scar, Postoperative infection, skin burn and tracheoesophageal injury and other complications. On 1 day after ablation, no blood supply was found in the nodules, and the VRR in the RFA group and the MWA group were 23.8% and 22.6%, respectively. There was no significant difference in the therapeutic effect between the two groups (P < 0. 127). Conclusion RFA and MWA are safe and effective in the treatment of benign thyroid nodules with few complications.
【作者單位】： 復(fù)旦大學(xué)附屬中山醫(yī)院內(nèi)分泌科;復(fù)旦大學(xué)附屬中山醫(yī)院超聲科;復(fù)旦大學(xué)附屬中山醫(yī)院介入治療科;
【基金】：國(guó)家自然科學(xué)基金青年項(xiàng)目(81201170)~~
【分類號(hào)】：R581
本文編號(hào)：2285634
[Abstract]:Objective to evaluate the safety and efficacy of radiofrequency ablation (radiofrequency ablation,RFA) and microwave ablation (microwave ablation,MWA) in benign thyroid nodules. Methods from June 2016 to February 2017, 13 patients with benign thyroid nodules were treated with RFA (13 cases) and MWA (21 cases) under ultrasound guidance. The changes of thyroid function and serum antibody were observed and compared after two kinds of ablation. Complications and reduction rate of thyroid nodules (volume reduction rate,VRR). Results there was no difference in serum free triiodothyronine (free triiodothyronine,fT3), free thyroxine (free thyroxine,fT4), thyrotropin (thyroid stimulating hormone,TSH), anti-thyroglobulin antibody (anti-thyroglobulin antibodies,TG-Ab) and anti-thyroid peroxidase antibody (thyroid peroxidase antibodies,TPO-Ab) in all patients before and after treatment. Statistical significance (P0.05). MWA group, 1 patient with mild hoarseness after operation, RFA group 1 patient with intraoperative bleeding more than 10 mL, patients did not develop cervical scar, Postoperative infection, skin burn and tracheoesophageal injury and other complications. On 1 day after ablation, no blood supply was found in the nodules, and the VRR in the RFA group and the MWA group were 23.8% and 22.6%, respectively. There was no significant difference in the therapeutic effect between the two groups (P < 0. 127). Conclusion RFA and MWA are safe and effective in the treatment of benign thyroid nodules with few complications.
【作者單位】： 復(fù)旦大學(xué)附屬中山醫(yī)院內(nèi)分泌科;復(fù)旦大學(xué)附屬中山醫(yī)院超聲科;復(fù)旦大學(xué)附屬中山醫(yī)院介入治療科;
【基金】：國(guó)家自然科學(xué)基金青年項(xiàng)目(81201170)~~
【分類號(hào)】：R581
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