二妙二活湯治療類風(fēng)濕關(guān)節(jié)炎關(guān)節(jié)鏡術(shù)后的早期臨床觀察
發(fā)布時間：2018-10-09 13:55
【摘要】：目的研究二妙二活湯治療類風(fēng)濕關(guān)節(jié)炎關(guān)節(jié)鏡滑膜清理術(shù)后的早期臨床療效,并與關(guān)節(jié)鏡滑膜清理手術(shù)結(jié)合常規(guī)西醫(yī)方法治療類風(fēng)濕關(guān)節(jié)炎對比,客觀評價二妙二活湯治療類風(fēng)濕關(guān)節(jié)炎的臨床療效及安全性。方法選取被確診的60例類風(fēng)濕膝關(guān)節(jié)炎腫脹患者,均行關(guān)節(jié)鏡滑膜清理術(shù)治療。隨機(jī)將患者分為對照組30例和觀察組30例;對照組術(shù)后進(jìn)行常規(guī)西醫(yī)止痛、抗風(fēng)濕治療,觀察組在此基礎(chǔ)上服用二妙二活湯。分別觀察兩組患者的膝關(guān)節(jié)疼痛評分(VAS)、膝關(guān)節(jié)腫脹度、HSS評分、超敏C反應(yīng)蛋白(CRP)、類風(fēng)濕因子(RF)、關(guān)節(jié)液蛋白多糖(PG),并根據(jù)中醫(yī)療效判定標(biāo)準(zhǔn)進(jìn)行評價。結(jié)果在術(shù)后第7天觀察組的VAS評分、術(shù)后腫脹度較對照組顯著降低(P0.05),而在術(shù)后第3天、術(shù)后2周的組間比較則無明顯統(tǒng)計學(xué)差異(P0.05);在術(shù)前、術(shù)后2周觀察組和對照組中血CRP、RF、及膝關(guān)節(jié)液中PG含量的組內(nèi)比較均有顯著降低(P0.01),在術(shù)后2周觀察組較對照組有顯著的降低(P0.05);術(shù)后2周觀察組與對照組HSS評分優(yōu)良率分別為80.0%與73.3%,有明顯統(tǒng)計學(xué)差異(P0.05);術(shù)后2周觀察組與對照組中醫(yī)評分優(yōu)良率分別為86.6%與83.3%,有明顯統(tǒng)計學(xué)差異(P0.05)。結(jié)論二妙二活湯應(yīng)用于類風(fēng)濕膝關(guān)節(jié)炎患者的關(guān)節(jié)鏡滑膜清理術(shù)后,對比常規(guī)西醫(yī)治療,更大力度地降低CRP、RF、PG的水平,更快地改善患者疼痛、腫脹等癥狀,通過提高患者的滿意度和依從性,獲得更好的關(guān)節(jié)功能康復(fù),提高臨床療效。
[Abstract]:Objective to study the early clinical effect of Ermiao Erhuo decoction in the treatment of rheumatoid arthritis after arthroscopic synovial debridement, and to compare it with arthroscopic synovial debridement combined with routine western medicine in the treatment of rheumatoid arthritis. Objective to evaluate the clinical efficacy and safety of Ermiao Erhuo decoction in the treatment of rheumatoid arthritis. Methods 60 patients with rheumatoid arthritis and swelling were treated by arthroscopic synovial debridement. The patients were randomly divided into control group (n = 30) and observation group (n = 30). The knee pain score (VAS),) and the hypersensitive C-reactive protein (CRP), rheumatoid factor (RF),) (RF), proteoglycan (PG), in the joint fluid of the two groups were observed and evaluated according to the criteria of traditional Chinese medicine (TCM). Results on the 7th day after operation, the VAS score in the observation group was significantly lower than that in the control group (P0.05), but there was no significant difference between the groups on the 3rd day and the 2nd week after operation (P0.05). The levels of CRP,RF, and PG in the knee joint fluid in the observation group and control group were significantly lower than those in the control group at 2 weeks after operation (P0.01), and the HSS scores in the observation group and the control group were better at 2 weeks after operation than in the control group (P0.05). The rate was 80.0% and 73.3% respectively, there was significant difference (P0.05); the observation group and the control group were 86.6% and 83.3%, there was significant statistical difference (P0.05). 2 weeks after operation, the excellent and good rate of TCM score in observation group and control group were 86.6% and 83.3%, respectively. Conclusion Ermiao Erhuo decoction is used in arthroscopic synovial debridement in patients with rheumatoid knee arthritis. Compared with routine western medicine, Ermiao Erhuo decoction can reduce the level of CRP,RF,PG and improve pain and swelling more quickly. By improving patients' satisfaction and compliance, we can obtain better rehabilitation of joint function and improve clinical efficacy.
【學(xué)位授予單位】：浙江中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R593.22
本文編號：2259585
[Abstract]:Objective to study the early clinical effect of Ermiao Erhuo decoction in the treatment of rheumatoid arthritis after arthroscopic synovial debridement, and to compare it with arthroscopic synovial debridement combined with routine western medicine in the treatment of rheumatoid arthritis. Objective to evaluate the clinical efficacy and safety of Ermiao Erhuo decoction in the treatment of rheumatoid arthritis. Methods 60 patients with rheumatoid arthritis and swelling were treated by arthroscopic synovial debridement. The patients were randomly divided into control group (n = 30) and observation group (n = 30). The knee pain score (VAS),) and the hypersensitive C-reactive protein (CRP), rheumatoid factor (RF),) (RF), proteoglycan (PG), in the joint fluid of the two groups were observed and evaluated according to the criteria of traditional Chinese medicine (TCM). Results on the 7th day after operation, the VAS score in the observation group was significantly lower than that in the control group (P0.05), but there was no significant difference between the groups on the 3rd day and the 2nd week after operation (P0.05). The levels of CRP,RF, and PG in the knee joint fluid in the observation group and control group were significantly lower than those in the control group at 2 weeks after operation (P0.01), and the HSS scores in the observation group and the control group were better at 2 weeks after operation than in the control group (P0.05). The rate was 80.0% and 73.3% respectively, there was significant difference (P0.05); the observation group and the control group were 86.6% and 83.3%, there was significant statistical difference (P0.05). 2 weeks after operation, the excellent and good rate of TCM score in observation group and control group were 86.6% and 83.3%, respectively. Conclusion Ermiao Erhuo decoction is used in arthroscopic synovial debridement in patients with rheumatoid knee arthritis. Compared with routine western medicine, Ermiao Erhuo decoction can reduce the level of CRP,RF,PG and improve pain and swelling more quickly. By improving patients' satisfaction and compliance, we can obtain better rehabilitation of joint function and improve clinical efficacy.
【學(xué)位授予單位】：浙江中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R593.22
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