【摘要】：目的了解新疆維吾爾族甲狀腺結(jié)節(jié)患病率,并探討其影響因素。方法于2015年9—12月,采用分層整群隨機(jī)抽樣方法,選取新疆烏魯木齊市天山區(qū)18~80歲的居民為調(diào)查對象。發(fā)放流行病學(xué)調(diào)查表,調(diào)查內(nèi)容包括一般情況、甲狀腺疾病史及家族史,飲食及生活習(xí)慣;體格檢查檢測血壓、身高、體質(zhì)量、腰圍,計(jì)算體質(zhì)指數(shù)(BMI);采集空腹靜脈血及晨尿,檢測血糖、血脂、尿酸、糖化血紅蛋白、尿碘等;采用甲狀腺超聲檢查確診甲狀腺結(jié)節(jié)。采用單因素及多因素Logistic回歸分析甲狀腺結(jié)節(jié)患病的影響因素。結(jié)果納入1 500例,共1 268例完成調(diào)查,實(shí)際調(diào)查率為84.53%。調(diào)查對象甲狀腺結(jié)節(jié)粗患病率為27.21%(345/1 268),男性粗患病率為20.49%(118/576),女性粗患病率為32.80%(227/692)。女性甲狀腺結(jié)節(jié)患病率高于男性(χ~2=24.080,P0.01)。18~29、30~39、40~49、50~59、60~80歲甲狀腺結(jié)節(jié)患病率分別為14.55%(55/378)、16.07%(45/280)、29.93%(88/294)、45.15%(93/206)、58.18%(64/110),隨著年齡的增長,甲狀腺結(jié)節(jié)患病率逐漸升高(χ_(趨勢)~2=126.591,P0.01)。單因素Logistie回歸分析結(jié)果顯示,女性(OR=1.895)、年齡(OR=1.056)、輕度進(jìn)食鹽習(xí)慣(OR=1.697)、吸煙史(OR=1.431)、甲狀腺功能減退(OR=1.555)、甲狀腺腫(OR=6.351)、糖尿病(OR=2.481)、高血壓(OR=2.925)、血脂異常(OR=1.928)、BMI為24.0~27.9 kg/m~2(OR=1.542)和≥28.0 kg/m~2(OR=2.721)、腰圍(OR=2.639)、空腹血糖(FPG)(OR=2.645)、口服葡萄糖耐量試驗(yàn)(OGTF)2 h血糖(OR=2.542)、收縮壓(OR=3.180)、舒張壓(OR=2.928)、三酰甘油(TG)(OR=1.586)、總膽固醇(TC)(OR=1.714)、低密度脂蛋白(LDL)(OR=1.684)、糖化血紅蛋白(OR=1.864)、促甲狀腺激素(TSH)4.20 mU/L(OR=1.554)、甲狀腺過氧化物酶抗體(TPOAb)(OR=1.479)、甲狀腺球蛋白抗體(TGAb)(OR=1.581)是甲狀腺結(jié)節(jié)的影響因素(P0.05)。多因素Logistic回歸分析結(jié)果顯示,性別(OR=2.044)、年齡(OR=1.046)和收縮壓(OR=2.638)是甲狀腺結(jié)節(jié)的獨(dú)立影響因素(P0.05)。結(jié)論新疆維吾爾族甲狀腺結(jié)節(jié)患病率較高,危險(xiǎn)因素較多,尤其是對于女性、高齡、高血壓患者,應(yīng)做到早預(yù)防、早診斷、早治療。
[Abstract]:Objective to investigate the prevalence of thyroid nodule in Uygur nationality of Xinjiang and its influencing factors. Methods from September to December, 2015, stratified cluster random sampling was used to select 1880 years old residents of Tianshan District, Urumqi, Xinjiang. An epidemiological questionnaire was issued, which included general information, history of thyroid diseases and family history, diet and lifestyle, physical examination, blood pressure, height, body mass, waist circumference, fasting venous blood and morning urine collected by calculating body mass index (BMI);). Blood glucose, blood lipids, uric acid, glycosylated hemoglobin, urine iodine, etc. Thyroid nodules were diagnosed by thyroid ultrasound. Univariate and multivariate Logistic regression analysis was used to analyze the risk factors of thyroid nodules. Results 1 500 cases were included and 1 268 cases completed the investigation. The actual investigation rate was 84.53. The crude prevalence rate of thyroid nodule was 27.21% (345 / 1 268), that of male was 20.49% (118 / 576) and that of female was 32.80% (227 / 692). The prevalence rate of thyroid nodule in female was higher than that in male (蠂 ~ 2 / 2 / 24.080 / P0.01). The prevalence rate of thyroid nodule was 14.55% (55 / 378) 16.07% (45 / 280) / 29.93% (% / 88294) and 58.18% (93.206) / (64 / 110) respectively. The prevalence rate of thyroid nodule increased with age (蠂 _ (trend) 2126.591P _ (0.01). Univariate Logistie regression analysis showed that, 濂蟲，

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