【摘要】：目的探討不同治療方法在絕經(jīng)早期婦女中的應(yīng)用效果,旨在為今后對絕經(jīng)早期婦女的治療提供參考。方法選取2013年5月至2016年5月該院收治的絕經(jīng)早期婦女2 143例,依據(jù)患者自己選擇的治療方式分為A組(雌激素+醋酸甲羥孕酮片)、B組(戊酸雌二醇+醋酸甲羥孕酮片)、C組(戊酸雌二醇+黃體酮膠丸)、D組(坤泰膠囊)、E組(黑升麻提取物),比較不同藥物治療下患者的性激素變化、絕經(jīng)癥狀及不良反應(yīng)。結(jié)果治療后3、6、12個月,A、B、C組患者的雌二醇水平逐漸升高,促卵泡生成素逐漸降低,與治療前比較差異有統(tǒng)計學(xué)意義(P0.05)。D、E組患者的雌二醇有升高趨勢,促卵泡生成素?zé)o明顯變化,二者與治療前比較差異均無統(tǒng)計學(xué)意義(P0.05)。治療后3、6、12個月,不同藥物治療下患者的改良Kupperman量表評分逐漸降低,與治療前比較差異有統(tǒng)計學(xué)意義(P0.05)。治療后3、6個月,A、B、C組患者的改良Kupperman量表評分明顯低于D、E組(P0.05),治療后12個月不同藥物治療下患者的改良Kupperman量表評分差異無統(tǒng)計學(xué)意義(P0.05)。A、B、C、D、E組的不良反應(yīng)總發(fā)生率分別為43.26%、38.26%、47.02%、13.07%、13.82%,差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論激素補充劑和天然藥物在改善絕經(jīng)早期癥狀方面成效顯著,其中激素補充劑見效更快,但不良反應(yīng)較為明顯;天然藥物對患者性激素影響不大,可能通過其他途徑發(fā)揮作用。
[Abstract]:Objective to explore the effect of different treatment methods in early menopausal women, and to provide reference for the treatment of early menopausal women in the future. Methods A total of 2,143 postmenopausal women admitted from May 2013 to May 2016 were selected. The patients were divided into group A (medroxyprogesterone acetate) and group B (estradiol valerate acetate medroxyprogesterone tablets), group C (estradiol valerate progesterone acetate) and group D (kuntai capsule). To compare the changes of sex hormones in patients treated with different drugs. Menopausal symptoms and adverse reactions. Results the level of estradiol and follicle stimulating hormone (FPO) gradually increased and follicle stimulating hormone (FPO) gradually decreased in group A (P 0.05). The level of estradiol in group E was significantly higher than that before treatment (P 0.05), but there was no significant change in follicle stimulating hormone (FPO) in group A (P 0.05) .There was no significant change in the level of estradiol in group A (P 0.05). There was no significant difference between the two groups before treatment (P0.05). The scores of the modified Kupperman scale were gradually decreased after 3 months and 12 months of treatment under different drug treatments, which was significantly different from that before treatment (P0.05). The scores of modified Kupperman scale in group C were significantly lower than those in group E (P0.05). There was no significant difference in scores of modified Kupperman scale for patients treated with different drugs at 12 months after treatment (P0.05). The total incidence of adverse reactions in group C was significantly lower than that in group C (P0.05). The difference was statistically significant (P0.05). Conclusion hormone supplements and natural drugs are effective in improving early menopausal symptoms, among which hormone supplements are more effective, but adverse reactions are more obvious, and natural drugs have little effect on sex hormones in patients. It may work in other ways.
【作者單位】： 四川省綿陽市中醫(yī)醫(yī)院婦產(chǎn)科;
【分類號】：R711.75

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