發(fā)布時間：2018-09-18 17:31

【摘要】：目的探究睡眠時間與2型糖尿病發(fā)病風(fēng)險的關(guān)系,分析睡眠時間與2型糖尿病發(fā)病風(fēng)險的劑量反應(yīng)關(guān)系。方法計算機檢索Pub Med、Web of Science、中國知網(wǎng)、萬方數(shù)據(jù)知識服務(wù)平臺建庫至2015-09-22有關(guān)睡眠時間與2型糖尿病發(fā)病風(fēng)險的前瞻性研究,通過文獻(xiàn)質(zhì)量評價后,提取調(diào)整混雜因素后的相關(guān)數(shù)據(jù),采用Stata 12.0和R 3.2.2軟件分別對數(shù)據(jù)進行常規(guī)Meta分析和劑量反應(yīng)Meta分析。結(jié)果共納入15個研究,睡眠時間與2型糖尿病發(fā)病風(fēng)險關(guān)系的常規(guī)Meta分析結(jié)果顯示,與正常組比較,睡眠時間過短組2型糖尿病發(fā)病風(fēng)險增加36%〔RR=1.36,95%CI(1.23,1.50),P0.001〕,睡眠時間過長組2型糖尿病發(fā)病風(fēng)險增加23%〔RR=1.23,95%CI(1.09,1.39),P=0.001〕。亞組分析結(jié)果顯示,睡眠時間過短組在除歐洲地區(qū)亞組的其他亞組中均增加了2型糖尿病的發(fā)病風(fēng)險(PZ0.05);睡眠時間過長組在兩種研究類型亞組、北美地區(qū)亞組及隨訪時間5~10年亞組中均增加了2型糖尿病的發(fā)病風(fēng)險(PZ0.05)。劑量反應(yīng)Meta分析結(jié)果顯示,睡眠時間與2型糖尿病發(fā)病風(fēng)險呈非線性劑量反應(yīng)關(guān)系,呈U型關(guān)系。與參照睡眠時間7.0 h/晚比較,睡眠時間5.5、6.0、6.5 h/晚2型糖尿病的發(fā)病風(fēng)險為1.20〔95%CI(1.15,1.25)〕、1.10〔95%CI(1.08,1.13)〕、1.04〔95%CI(1.03,1.05)〕,睡眠時間7.5、8.0 h/晚2型糖尿病的發(fā)病風(fēng)險為1.00〔95%CI(0.98,1.01)〕、1.02〔95%CI(0.99,1.06)〕,睡眠時間8.5、9.0、9.5 h/晚2型糖尿病的發(fā)病風(fēng)險為1.07〔95%CI(1.01,1.14)〕、1.14〔95%CI(1.04,1.26)〕、1.23〔95%CI(1.07,1.40)〕。結(jié)論睡眠時間過短和過長與2型糖尿病發(fā)病風(fēng)險增加密切相關(guān);睡眠時間7.0 h/晚是2型糖尿病發(fā)病風(fēng)險的危險因素,睡眠時間7.0~8.4 h/晚對2型糖尿病發(fā)病風(fēng)險的影響不明顯,而睡眠時間≥8.5 h/晚將導(dǎo)致2型糖尿病發(fā)病風(fēng)險增加。因此,合理的睡眠時間有利于預(yù)防2型糖尿病。
[Abstract]:Objective to explore the relationship between sleep time and risk of type 2 diabetes mellitus and analyze the dose response relationship between sleep time and risk of type 2 diabetes mellitus. Methods A prospective study of sleep time and risk of type 2 diabetes mellitus was searched by Pub Med,Web of Science, China knowledge Network, Wanfang data Service platform and 2015-09-22. The quality of the literature was evaluated. The relative data after adjusting confounding factors were extracted and the data were analyzed by Stata 12.0 and R3.2.2 respectively by conventional Meta analysis and dose-response Meta analysis. Results A total of 15 studies were conducted. Routine Meta analysis of the relationship between sleep time and the risk of type 2 diabetes mellitus showed that the risk of type 2 diabetes increased by 36% (RR=1.36,95%CI (1.231.50) / P0.001) in the short sleep duration group compared with the normal group. The risk of type 2 diabetes increased by 23% (RR=1.23,95%CI _ (1.09) 1.39). The results of subgroup analysis showed that the risk of type 2 diabetes mellitus (PZ0.05) was increased in the short sleep duration group in all the subgroups except the European subgroup, and in the two study subgroups in the long sleep duration group. The risk of type 2 diabetes mellitus (PZ0.05) was increased in the North American subgroup and follow-up subgroup for 5 to 10 years. The results of dose response Meta analysis showed that sleep time had a nonlinear dose response relationship with the risk of type 2 diabetes mellitus and a U type relationship. Compared with reference sleep time of 7.0 h / night, the risk of type 2 diabetes was 1.20 (95%CI (1.151.25) 1.10 (95%CI (1.081.13) 1.04 (95%CI (1.031.05), sleep time 7.58.0 h / night diabetes) 1.00 (95%CI (0.981.01) 1.02 (95%CI (0.991.06),). The risk of type 2 diabetes mellitus was 1.07 (95%CI (1.01-1.14) 1.14 (95%CI (1.041.26) 1.23 (95%CI (1.071.40). Conclusion the short and long sleep time is closely related to the increased risk of type 2 diabetes mellitus, and 7.0 h / night sleep time is the risk factor of type 2 diabetes mellitus, but the effect of sleeping time 7.0g 8.4 h / night on the risk of type 2 diabetes mellitus is not obvious. Sleep time 鈮，

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