【摘要】：目的探討系統(tǒng)性紅斑狼瘡(SLE)患者發(fā)生肺動脈高壓(PAH)的危險因素。方法通過計算機檢索和文獻追溯的方法,檢索Pub Med、中國知網(wǎng)和萬方數(shù)據(jù)知識服務(wù)平臺中SLE患者發(fā)生PAH危險因素的相關(guān)文獻,時間限定為建庫至2015年1月。兩名研究員獨立進行文獻篩選并提取文獻資料,包括第一作者、發(fā)表時間、病例收集時間、樣本量、研究因素,采用紐卡斯?fàn)?渥太華量表(NOS)對納入文獻進行質(zhì)量評價。依據(jù)比值比(OR值)及其95%CI評估各臨床表現(xiàn)及實驗室指標(biāo)與SLE患者發(fā)生PAH的關(guān)系。結(jié)果納入15篇病例對照研究,NOS評分均≥7分,文獻總體質(zhì)量較高。出現(xiàn)雷諾現(xiàn)象的SLE患者發(fā)生PAH的風(fēng)險高于未出現(xiàn)雷諾現(xiàn)象者〔OR=3.96,95%CI(2.94,5.34),P0.05〕。有無皮膚血管炎的SLE患者發(fā)生PAH的風(fēng)險比較,差異無統(tǒng)計學(xué)意義(P0.05)�？购颂呛说鞍�(RNP)抗體陽性的SLE患者發(fā)生PAH的風(fēng)險高于抗RNP抗體陰性者〔OR=3.32,95%CI(2.37,4.66),P0.05〕�？剐牧字�(ACL)-IgG抗體陽性的SLE患者發(fā)生PAH的風(fēng)險高于抗ACL-IgG抗體陰性者〔OR=3.36,95%CI(2.37,4.76),P0.05〕。合并漿膜炎的SLE患者發(fā)生PAH的風(fēng)險高于無漿膜炎者〔OR=2.63,95%CI(1.50,4.59),P0.05〕。合并肺間質(zhì)病變的SLE患者發(fā)生PAH的風(fēng)險高于無肺間質(zhì)病變者〔OR=4.65,95%CI(3.13,6.88),P0.05〕。結(jié)論雷諾現(xiàn)象、抗RNP抗體陽性、抗ACL-IgG抗體陽性、漿膜炎、肺間質(zhì)病變是SLE患者發(fā)生PAH的危險因素。
[Abstract]:Objective to investigate the risk factors of pulmonary hypertension (PAH) in patients with systemic lupus erythematosus (SLE). Methods by means of computer retrieval and literature tracing, we searched the literature about the risk factors of PAH in SLE patients in Pub Med, China knowledge Network and Wanfang data knowledge Service platform. The time limit was to build the database until January 2015. The two researchers independently screened and extracted the literature, including the first author, publication time, case collection time, sample size and factors. The quality of the literature was evaluated by Newcastle Ottawa scale (NOS). According to the ratio (OR) and its 95%CI, the relationship between the clinical manifestations and laboratory indexes and the incidence of PAH in SLE patients was evaluated. Results the NOS scores of 15 case-control studies were all 鈮，

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