青海地區(qū)藏漢族2型糖尿病臨床特點(diǎn)比較分析
發(fā)布時(shí)間：2018-08-27 14:36
【摘要】：目的通過對(duì)青海地區(qū)藏漢族2型糖尿病(T2DM)患者臨床特點(diǎn)進(jìn)行比較,探討藏族T2DM臨床特點(diǎn)、發(fā)生發(fā)展的病理特點(diǎn)及其可能影響因素。方法收集2014年1月-2015年12月青海大學(xué)附屬醫(yī)院內(nèi)分泌科診斷為T2DM(均符合1999年WHO的DM診斷標(biāo)準(zhǔn))的藏漢族同期住院患者的臨床資料。進(jìn)行比較分析。結(jié)果藏漢族非體力勞動(dòng)患者構(gòu)成比均較高。藏族患者在腰圍、BMI、HbAlc、FPG、血糖曲線下總面積、LDL-C、ALT、WBC、MCHC、PLT、PCT、HOMA-IR臨床指標(biāo)方面顯著高于漢族,具有統(tǒng)計(jì)學(xué)意義(分別P0.05),但口服100g饅頭OGTT試驗(yàn)中的C肽曲線下反應(yīng)面積、HDL-C、ALB、MPV、PDW方面又顯著低于漢族,具有統(tǒng)計(jì)學(xué)意義(分別P0.05)。上述特點(diǎn)藏族男性表現(xiàn)較為突出。但慢性并發(fā)癥及代謝綜合征患病率方面藏漢族并無明顯區(qū)別。結(jié)論結(jié)果提示較高的肥胖體質(zhì)是藏族T2DM患者的重要臨床表現(xiàn),其胰島素抵抗程度高于漢族患者,這可能與肥胖合并肝臟損害有關(guān)。與漢族相比,藏族患者所具有較高的LDL-C可能與其生活方式不無關(guān)系。其血糖水平的增高除上述因素外,胰島細(xì)胞功能的下降亦是其重要原因之一。盡管藏族民族特點(diǎn)、居住海拔和漢族存在一些差異,但藏漢族T2DM慢性并發(fā)癥及代謝綜合征患病率方面并無顯著統(tǒng)計(jì)學(xué)意義,提示它們發(fā)生的病理機(jī)制可能是一致的。因此改善體力活動(dòng)和飲食結(jié)構(gòu)有可能是預(yù)防高原DM的必要措施。
[Abstract]:Objective to compare the clinical characteristics of type 2 diabetes mellitus (T2DM) in Tibetan and Han nationality in Qinghai, and to explore the clinical characteristics, pathological characteristics and possible influencing factors of Tibetan T2DM. Methods from January 2014 to December 2015, the clinical data of patients with T2DM diagnosed by Endocrinology Department of affiliated Hospital of Qinghai University (all in accordance with the DM diagnostic criteria of 1999 WHO) were collected. A comparative analysis was carried out. Results the composition ratio of non-manual labor patients in Tibetan and Han nationality was higher than that in Han nationality. In Tibetan patients, the total area under the blood glucose curve was significantly higher than that in the Han nationality (P 0.05), but the response area under the C-peptide curve of 100g steamed bread OGTT test was significantly lower than that of the Han nationality (P < 0.05), and the total area under the blood glucose curve was significantly lower than that of the Han nationality (P < 0.05), and the total area under the blood glucose curve was significantly lower in the Tibetan patients than that in the Han nationality (P < 0.05), but the response area under the C-peptide curve in the 100g OGTT test was significantly lower than that in the Han nationality (P < 0.05). There was statistical significance (P0.05). The above characteristics of Tibetan male performance is more prominent. However, there was no significant difference in the prevalence of chronic complications and metabolic syndrome between Tibetan and Han nationality. Conclusion the results suggest that higher obesity constitution is an important clinical manifestation of Tibetan patients with T2DM, and the degree of insulin resistance is higher than that of Han nationality patients, which may be related to obesity with liver damage. Compared with the Han nationality, the higher LDL-C of Tibetan patients may be related to their lifestyle. In addition to the above factors, the decrease of islet cell function is one of the important reasons. Although there were some differences between Tibetan nationality and Han nationality, there was no significant difference in the prevalence of chronic complications and metabolic syndrome of T2DM in Tibetan and Han nationality, suggesting that the pathogenetic mechanism of them might be the same. Therefore, improving physical activity and dietary structure may be the necessary measures to prevent DM at high altitude.
【學(xué)位授予單位】：青海大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R587.1
本文編號(hào)：2207578
[Abstract]:Objective to compare the clinical characteristics of type 2 diabetes mellitus (T2DM) in Tibetan and Han nationality in Qinghai, and to explore the clinical characteristics, pathological characteristics and possible influencing factors of Tibetan T2DM. Methods from January 2014 to December 2015, the clinical data of patients with T2DM diagnosed by Endocrinology Department of affiliated Hospital of Qinghai University (all in accordance with the DM diagnostic criteria of 1999 WHO) were collected. A comparative analysis was carried out. Results the composition ratio of non-manual labor patients in Tibetan and Han nationality was higher than that in Han nationality. In Tibetan patients, the total area under the blood glucose curve was significantly higher than that in the Han nationality (P 0.05), but the response area under the C-peptide curve of 100g steamed bread OGTT test was significantly lower than that of the Han nationality (P < 0.05), and the total area under the blood glucose curve was significantly lower than that of the Han nationality (P < 0.05), and the total area under the blood glucose curve was significantly lower in the Tibetan patients than that in the Han nationality (P < 0.05), but the response area under the C-peptide curve in the 100g OGTT test was significantly lower than that in the Han nationality (P < 0.05). There was statistical significance (P0.05). The above characteristics of Tibetan male performance is more prominent. However, there was no significant difference in the prevalence of chronic complications and metabolic syndrome between Tibetan and Han nationality. Conclusion the results suggest that higher obesity constitution is an important clinical manifestation of Tibetan patients with T2DM, and the degree of insulin resistance is higher than that of Han nationality patients, which may be related to obesity with liver damage. Compared with the Han nationality, the higher LDL-C of Tibetan patients may be related to their lifestyle. In addition to the above factors, the decrease of islet cell function is one of the important reasons. Although there were some differences between Tibetan nationality and Han nationality, there was no significant difference in the prevalence of chronic complications and metabolic syndrome of T2DM in Tibetan and Han nationality, suggesting that the pathogenetic mechanism of them might be the same. Therefore, improving physical activity and dietary structure may be the necessary measures to prevent DM at high altitude.
【學(xué)位授予單位】：青海大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R587.1
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1 徐斐斐;青海地區(qū)藏漢族2型糖尿病臨床特點(diǎn)比較分析[D];青海大學(xué);2016年
，本文編號(hào)：2207578
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