【摘要】：目的:本研究通過對30名超重肥胖志愿者進行為期8周的間歇性斷食干預(yù),以明確其帶來的健康效應(yīng),及進一步探討對運動步數(shù)、飲食行為、饑餓感、飽腹感和滿足感的改變及安全性分析,為后期間歇性斷食結(jié)合步行運動作為社區(qū)防治超重肥胖技術(shù)進行推廣提供科學(xué)依據(jù)。方法:本研究以通過南昌市疾控微信平臺招募的30名超重肥胖志愿者為研究對象。進行為期8周的間歇性斷食干預(yù),比較和分析干預(yù)前后的超重肥胖患者形態(tài)指標(biāo)(身高、體重、臀圍、腰圍、體脂率及派生的腰臀比和體重指數(shù))、安靜血壓、心率、血液(尿液)生化指標(biāo)、飲食行為、VAS量表(饑餓感、飽腹感、滿足感)、運動步數(shù)等指標(biāo),并對干預(yù)效果進行評價。結(jié)果:(1)通過8周干預(yù),30名志愿者的身體形態(tài)指標(biāo)均顯著下降(P0.01)。其中,體重下降3.36±1.93kg、腰圍減少5.11±4.79cm、臀圍減少2.70±3.81cm、腰臀比下降0.03±0.04、體脂率降低1.71±1.63%、BMI下降1.20±0.75kg/m2。血脂血壓方面,干預(yù)后DBP、SBP、GLU、TG、HDL-C、LDL-C均有所改善。其中,SBP,TG變化在干預(yù)前后有統(tǒng)計學(xué)意義(P0.05)。在肝腎功能方面,ALT、AST、ALB、UREA、CRE值在干預(yù)8周后均有下降,具有統(tǒng)計學(xué)意義(P0.05)。(2)8周每日平均運動步數(shù)為10987±1998,非斷食日的平均運動步數(shù)為11070±1975,斷食日的平均運動步數(shù)為10859±2210,間歇性斷食日和非斷食日的運動量差別沒有統(tǒng)計學(xué)意義(F=0.141,P=0.708)。且非斷食日運動步數(shù)(P=0.209)、斷食日的運動步數(shù)(P=0.303)、每周平均運動步數(shù)(P=0.164)和非斷食日與斷食日的運動步數(shù)差異在8周之內(nèi)均未顯示有統(tǒng)計學(xué)意義(P0.05)。(3)干預(yù)8周后,受試者出現(xiàn)饑餓感下降和飽腹感上升(P0.05),而滿足感未顯示有統(tǒng)計學(xué)意義(P0.05)。(4)比較第1周、第4周、第8周CR、UE、EE得分,差異具有統(tǒng)計學(xué)意義。認(rèn)知限制性進食(CR)維度得分增加了(F=4.23,P0.05),非控制進食維度(UE)得分(F=11.331,P0.05)和情緒性進食(EE)維度得分減少了(F=5.961,P0.05)。(5)8周內(nèi)18名受試者出現(xiàn)不良反應(yīng),12名受試者未見不良反應(yīng)。主要的不良反應(yīng)為頭暈(n=9,30.00%)和口渴(n=6,20.00%),其他的不良反應(yīng)如胃脹氣(n=2,6.67%),注意力下降(n=2,6.67%),低血糖(n=2,6.67%),腰背痛(n=2,6.67%),惡寒(n=1,3.33%)出現(xiàn)較少。結(jié)論:8周間歇性斷食結(jié)合累計10000步步行運動可有效改善超重和肥胖志愿者的形態(tài)指標(biāo)、血液生化指標(biāo)、血壓、肝腎功能相關(guān)指標(biāo),減肥效果良好。每天運動步數(shù)在7000-10000范圍之內(nèi),特別是在非斷食日內(nèi),受試者是可以耐受的,證明步行運動是間歇性斷食一種很好的附加治療方法。間歇性斷食對飲食行為(CR,UR,EE)均產(chǎn)生了積極的變化,而且有利于降低饑餓感并增加飽腹感,這種變化有利于長期穩(wěn)定地減少體重�？傊�,間歇性斷食是一種效果好、簡單易行、容易長期堅持的方法,這提示后期間歇性斷食結(jié)合步行運動作為社區(qū)超重肥胖防治技術(shù)進行推廣是可行的。
[Abstract]:AIM: To investigate the health effects of intermittent dietary intervention on 30 overweight and obese volunteers for 8 weeks, and to explore the changes and safety of exercise steps, dietary behavior, hunger, satiety and satisfaction in order to prevent and treat overweight in the community. Methods: Thirty overweight and obese volunteers recruited by the Nanchang CDC Weixin Platform were selected as the subjects of this study. Intermittent diet intervention was conducted for 8 weeks. Morphological indexes (height, weight, hip circumference, waist circumference, body fat rate and derivative) of overweight and obese patients before and after intervention were compared and analyzed. Waist-hip ratio and body mass index (BMI), quiet blood pressure, heart rate, blood (urine) biochemical indicators, dietary behavior, VAS (hunger, satiety, satisfaction), and the number of exercise steps were evaluated. Results: (1) After 8 weeks of intervention, 30 volunteers'body shape indicators were significantly decreased (P 0.01). Among them, body weight loss was 3.36 (1.93 kg), and so on. The waist circumference decreased by 5.11+4.79 cm, the hip circumference decreased by 2.70+3.81 cm, the waist-hip ratio decreased by 0.03+0.04, the body fat rate decreased by 1.71+1.63%, and the BMI decreased by 1.20+0.75 kg/m2. The blood lipid and blood pressure of DBP, SBP, GLU, TG, HDL-C and LDL-C were improved after the intervention. The changes of SBP and TG were statistically significant before and after the intervention (P 0.05). E value decreased after 8 weeks of intervention, with statistical significance (P 0.05). (2) The average daily exercise pace of 8 weeks was 10987 There was no significant difference between the exercise steps on the breaking day (P = 0.209), the exercise steps on the breaking day (P = 0.303), the average exercise steps per week (P = 0.164) and the exercise steps on the breaking day and the breaking day (P 0.05). (3) After 8 weeks of intervention, the subjects showed a decrease in hunger and an increase in satiety (P 0.05). Comparing the scores of CR, UE and EE in the first week, the fourth week and the eighth week, the difference was statistically significant. The scores of CR, UE and EE increased (F = 4.23, P 0.05), UE and EE decreased (F = 11.331, P 0.05) and EE decreased (F = 5.961, P 0.05) in the fifth week. The main adverse reactions were dizziness (n = 9,30.00%) and thirst (n = 6,20.00%). Other adverse reactions were gastric distention (n = 2,6.67%), decreased attention (n = 2,6.67%), hypoglycemia (n = 2,6.67%), low back pain (n = 2,6.67%) and cold (n = 1,3.33%). Exercise can effectively improve the morphological indexes, blood biochemical indexes, blood pressure, liver and kidney function related indexes of overweight and obese volunteers, and the weight loss effect is good. Methods. Intermittent fasting has a positive effect on dietary behavior (CR, UR, EE) and is conducive to reducing hunger and increasing satiety. This change is conducive to long-term stable weight loss. Exercise as a community overweight and obesity prevention and control technology is feasible.
【學(xué)位授予單位】：南昌大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R589.2

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