【摘要】：目的通過分析多囊卵巢綜合征(polycystic ovary syndrome,PCOS)病人與對照組的抑制素B(inhibin B,INHB)、抗苗勒管激素(anti-Müllerian hormone,AMH)及各項內分泌指標,探討INHB、AMH對PCOS的臨床預測價值及比較兩組內分泌指標的特點。方法選取2016年9月至2017年5月間在首都醫(yī)科大學附屬北京婦產醫(yī)院內分泌科就診的PCOS病人567例為研究組,取同期就診的年齡、原發(fā)不孕與繼發(fā)不孕病人或正常體檢者53例作為對照組。測量所有參與者的身高、體質量,空腹抽血查INHB、AMH、卵泡刺激素(follicle-stimulating hormone,FSH)、黃體生成素(luteinizing hormone,LH)、雌二醇(estradiol,E2)、睪酮(testosterone,T),分析PCOS組與對照組的血清INHB、AMH質量濃度及內分泌指標特點。結果 PCOS組的血清AMH質量濃度、LH、T、體質量指數(shù)(body mass index,BMI)均明顯高于對照組,E2、FSH/LH低于對照組,且組間差異均有統(tǒng)計學意義(P0.05)。PCOS組的INHB質量濃度高于對照組,FSH低于對照組,組間差異均無統(tǒng)計學意義(P0.05)。AMH預測多囊卵巢綜合征的最佳分界值(cut-off)值為4.84μg/L,敏感度為84.48%,特異度為69.81%。INHB預測多囊卵巢綜合征的cut-off值為70.8 ng/L,敏感度為53.97%,特異度為67.92%,AMH與INHB聯(lián)合預測(并聯(lián)試驗)多囊卵巢綜合征的敏感度為90.29%,特異度為54.92%。結論 AMH預測PCOS的cut-off值為4.84μg/L,INHB預測PCOS的cut-off值為70.8 ng/L,且AMH與INHB的聯(lián)合檢測(并列試驗)敏感度高于AMH單項檢測,這對臨床PCOS的預測有很重要的指導意義。
[Abstract]:Objective to investigate the clinical predictive value of (polycystic ovary B (inhibin and the characteristics of endocrine indexes in patients with polycystic ovary syndrome (polycystic ovary syndrome) and control group by analyzing the levels of B (inhibin, anti-M 眉 llerian hormone and endocrine indexes in patients with polycystic ovary syndrome (PCOS) and the control group. Methods A total of 567 PCOS patients from September 2016 to May 2017 in the Endocrinology Department of Beijing Obstetrics and Gynecology Hospital affiliated to Capital Medical University were selected as the study group. 53 cases of primary infertility and secondary infertility or normal physical examination were used as control group. The height and body mass of all participants were measured. The serum INHBAMH, follicle-stimulating hormone, luteinizing hormone LH, estradiol E 2 and T were measured. The serum INHBAMH concentration and endocrine parameters in PCOS group and control group were analyzed. Results the serum AMH concentration and body mass index (body mass) in the PCOS group were significantly higher than those in the control group, and the differences were statistically significant (P0.05). The INHB concentration in the PCOS group was significantly higher than that in the control group (P0.05), and the INHB concentration in the PCOS group was significantly higher than that in the control group. There was no significant difference between the two groups (P0.05) .AMH in predicting polycystic ovary syndrome (cut-off) was 4.84 渭 g / L, sensitivity was 84.48. The specificity of 69.81%.INHB in predicting polycystic ovary syndrome (PCOS) was 70.8 ng / L, sensitivity was 53.97, specificity was 67.92AMH combined with INHB. The sensitivity and specificity of predicting polycystic ovary syndrome (PCOS) were 90.29 and 54.92 respectively. Conclusion the cut-off value of PCOS predicted by AMH is 4.84 渭 g / L and the cut-off value of PCOS is 70.8 ng / L, and the sensitivity of AMH combined with INHB is higher than that of AMH, which is very important for clinical PCOS prediction.
【作者單位】： 首都醫(yī)科大學附屬北京婦產醫(yī)院婦科內分泌科;德國圖賓根大學婦產醫(yī)院內分泌與絕經(jīng)中心;
【基金】：首都臨床特色應用研究與成果推廣(Z161100000516143) 首都衛(wèi)生發(fā)展科研專項項目(2016-2-2113) 北京市醫(yī)院管理局臨床技術創(chuàng)新項目(XMLX201710) 北京市衛(wèi)生系統(tǒng)高層次衛(wèi)生技術人才(學科帶頭人)(2014-2-016) 國家外國專家局2017年度北京市引進國外技術、管理人才項目(20171100004)~~
【分類號】：R711.75

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