【摘要】：目的:探討滄州市健康體檢人群甲狀腺自身抗體的陽性率及其與甲狀腺功能異常的相關(guān)性。方法:采用電化學(xué)發(fā)光免疫分析技術(shù)測定滄州市3 218名健康體檢人群血清促甲狀腺激素(TSH)、游離三碘甲腺原氨酸(FT3)、游離甲狀腺素(FT4)、甲狀腺過氧化物酶抗體(TPOAb)和甲狀腺球蛋白抗體(Tg Ab),分別以TPOAb34 U/ml和Tg Ab115 U/ml為陽性,對檢測結(jié)果進行統(tǒng)計分析。結(jié)果:健康人群甲狀腺自身抗體的總陽性率為16.19%,且隨年份增加呈明顯的增高趨勢,不同性別之間的陽性檢出率有顯著性差異(P0.001),其中TPOAb、Tg Ab、TPOAb和Tg Ab同時陽性的檢出率分別為14.57%、12.74%和11.12%,1 686名女性的陽性檢出率(21.53%、19.16%、16.67%)顯著高于男性(6.92%、5.68%、5.03%),差異有統(tǒng)計學(xué)意義(P均0.001),且隨年齡增加陽性檢出率逐漸升高,女性陽性率高峰在≥70歲年齡組,男性陽性率高峰在50~59歲年齡組。甲亢和亞甲亢、甲減和亞甲減甲狀腺自身抗體的陽性檢出率和OR均有顯著性差異(P0.001)。結(jié)論:滄州市健康體檢人群甲狀腺自身抗體的陽性率較高,對甲狀腺功能正常而自身抗體陽性者進行動態(tài)監(jiān)測、隨訪或早期干預(yù),有利于甲狀腺疾病的早期診斷、鑒別診斷及其防治。
[Abstract]:Objective: to investigate the positive rate of thyroid autoantibodies and the correlation between thyroid autoantibodies and thyroid dysfunction. Methods: serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb), thyroid peroxidase antibody (TPOAb) and thyroid shape were determined by electrochemiluminescence immunoassay (ECLIA) in 3 218 healthy people in Cangzhou City. The (Tg Ab), of adenoglobulin antibody was positive for TPOAb34 U/ml and TG Ab115 U/ml, respectively. The test results were statistically analyzed. Results: the total positive rate of thyroid autoantibodies in healthy population was 16.19. The positive rates of TPO-Ab and Tg-Ab were 14.570.74% and 11.1212.74%, respectively, and 16.67% of them were higher than those of males (6.925.68%, P < 0.001), and the positive rates of TPO-Ab and Tg-Ab were 14.577.74% and 11.12121.686%, respectively, which were significantly higher than those in males (6.925.68%, P < 0.05), and there were significant differences between the two sexes (P < 0.01), and there were significant differences between the two groups (P < 0.05), and the positive rate of TG-Ab was significantly higher than that of males (P < 0.05). The positive rate increased with age. The peak of positive rate was in the age group of 鈮，

本文編號：2187995