【摘要】：目的:探討滄州市健康體檢人群甲狀腺自身抗體的陽(yáng)性率及其與甲狀腺功能異常的相關(guān)性。方法:采用電化學(xué)發(fā)光免疫分析技術(shù)測(cè)定滄州市3 218名健康體檢人群血清促甲狀腺激素(TSH)、游離三碘甲腺原氨酸(FT3)、游離甲狀腺素(FT4)、甲狀腺過(guò)氧化物酶抗體(TPOAb)和甲狀腺球蛋白抗體(Tg Ab),分別以TPOAb34 U/ml和Tg Ab115 U/ml為陽(yáng)性,對(duì)檢測(cè)結(jié)果進(jìn)行統(tǒng)計(jì)分析。結(jié)果:健康人群甲狀腺自身抗體的總陽(yáng)性率為16.19%,且隨年份增加呈明顯的增高趨勢(shì),不同性別之間的陽(yáng)性檢出率有顯著性差異(P0.001),其中TPOAb、Tg Ab、TPOAb和Tg Ab同時(shí)陽(yáng)性的檢出率分別為14.57%、12.74%和11.12%,1 686名女性的陽(yáng)性檢出率(21.53%、19.16%、16.67%)顯著高于男性(6.92%、5.68%、5.03%),差異有統(tǒng)計(jì)學(xué)意義(P均0.001),且隨年齡增加陽(yáng)性檢出率逐漸升高,女性陽(yáng)性率高峰在≥70歲年齡組,男性陽(yáng)性率高峰在50~59歲年齡組。甲亢和亞甲亢、甲減和亞甲減甲狀腺自身抗體的陽(yáng)性檢出率和OR均有顯著性差異(P0.001)。結(jié)論:滄州市健康體檢人群甲狀腺自身抗體的陽(yáng)性率較高,對(duì)甲狀腺功能正常而自身抗體陽(yáng)性者進(jìn)行動(dòng)態(tài)監(jiān)測(cè)、隨訪或早期干預(yù),有利于甲狀腺疾病的早期診斷、鑒別診斷及其防治。
[Abstract]:Objective: to investigate the positive rate of thyroid autoantibodies and the correlation between thyroid autoantibodies and thyroid dysfunction. Methods: serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb), thyroid peroxidase antibody (TPOAb) and thyroid shape were determined by electrochemiluminescence immunoassay (ECLIA) in 3 218 healthy people in Cangzhou City. The (Tg Ab), of adenoglobulin antibody was positive for TPOAb34 U/ml and TG Ab115 U/ml, respectively. The test results were statistically analyzed. Results: the total positive rate of thyroid autoantibodies in healthy population was 16.19. The positive rates of TPO-Ab and Tg-Ab were 14.570.74% and 11.1212.74%, respectively, and 16.67% of them were higher than those of males (6.925.68%, P < 0.001), and the positive rates of TPO-Ab and Tg-Ab were 14.577.74% and 11.12121.686%, respectively, which were significantly higher than those in males (6.925.68%, P < 0.05), and there were significant differences between the two sexes (P < 0.01), and there were significant differences between the two groups (P < 0.05), and the positive rate of TG-Ab was significantly higher than that of males (P < 0.05). The positive rate increased with age. The peak of positive rate was in the age group of 鈮，

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