高同型半胱氨酸血癥相關(guān)疾病診治
發(fā)布時間:2018-07-31 17:30
【摘要】:正1969年Mccully~([1])在遺傳性同型半胱氨酸血癥死亡兒童尸檢中發(fā)現(xiàn)廣泛的動脈血栓形成及動脈粥樣硬化(AS),首次提出高同型半胱氨酸血癥(HHcy)可導致AS性血管疾病的假說。Hcy通過氧化應激反應導致內(nèi)皮細胞和內(nèi)質(zhì)網(wǎng)損傷,破壞機體凝血和纖溶之間的平衡,使機體處于血栓前狀態(tài),引起血管平滑肌細胞增殖和膠原合成,加速AS進程。2006年美國心臟協(xié)會腦卒中指南~([2])將HHcy作為腦卒中獨立危險因素,確定診斷
[Abstract]:Mccully ~ (1) found extensive arterial thrombosis and atherosclerosis in autopsy of children with hereditary homocysteinemia in 1969. Hypothesis that hyperhomocysteinemia (HHcy) may lead to as vascular disease. Peroxidation stress induced endothelial cell and endoplasmic reticulum damage. It destroys the balance between coagulation and fibrinolysis, causes the body to be in a prethrombotic state, causes the proliferation of vascular smooth muscle cells and collagen synthesis, and accelerates the process of as. 2006 American Heart Association Stroke guidelines ~ (2) used HHcy as an independent risk factor for stroke. Definite diagnosis
【作者單位】: 甘肅省第二人民醫(yī)院心內(nèi)科;
【分類號】:R589.3
本文編號:2156324
[Abstract]:Mccully ~ (1) found extensive arterial thrombosis and atherosclerosis in autopsy of children with hereditary homocysteinemia in 1969. Hypothesis that hyperhomocysteinemia (HHcy) may lead to as vascular disease. Peroxidation stress induced endothelial cell and endoplasmic reticulum damage. It destroys the balance between coagulation and fibrinolysis, causes the body to be in a prethrombotic state, causes the proliferation of vascular smooth muscle cells and collagen synthesis, and accelerates the process of as. 2006 American Heart Association Stroke guidelines ~ (2) used HHcy as an independent risk factor for stroke. Definite diagnosis
【作者單位】: 甘肅省第二人民醫(yī)院心內(nèi)科;
【分類號】:R589.3
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