【摘要】：[目 的]：通過測定糖尿病前期患者糖基化終產(chǎn)物(AGEs)與踝肱指數(shù)(ABI),探討二者之間的相關(guān)性,為糖尿病前期下肢動脈病變的早期干預提供依據(jù)。[方法]：收集糖尿病前期患者(PDM)50例、高血壓患者(EH)28例,糖尿病前期合并高血壓患者(PDMEH)25例以及對照組患者(NC)52例。所有入選研究對象均使用多普勒血流探測儀測定ABI以及酶聯(lián)免疫吸附法測定AGEs濃度,并分析AGEs與ABI及其他指標的相關(guān)性。[結(jié)果]：1、經(jīng)簡單線性相關(guān)性分析：AGEs與ABI呈負相關(guān),與LDL、FPG呈正相關(guān)；2、二分類Logistic回歸分析：AGEs是ABI的危險因素。3、在糖尿病前期患者中,臨界組(1.4≥ABI≥1.0)中AGEs含量明顯高于正常組(0.9ABI1.0)(P0.05)；4、四組間年齡、WHR、TG、LDL、AGEs差異有統(tǒng)計學意義(P0.05)。[結(jié)論]：在糖尿病前期患者中,AGEs和ABI相關(guān),ABI值越低的患者,AGEs含量越高。AGEs可能與下肢動脈病變的發(fā)病風險相關(guān),但仍需進一步擴大樣本證實。
[Abstract]:Objective: to investigate the correlation between (AGEs) and malleolus brachial index (ABI),) in patients with prediabetes by measuring the end product of glycosylation, and to provide evidence for early intervention of arterial lesions of lower extremities in prediabetic patients. [methods] 50 cases of (PDM), 28 cases of (EH), 25 cases of (PDMEH) and 52 cases of control group were collected. The concentration of ABI and AGEs were measured by Doppler flow detector and enzyme linked immunosorbent assay (Elisa), and the correlation between AGEs and ABI and other indexes were analyzed. [results] by simple linear correlation analysis, the ratio ages was negatively correlated with ABI and positively correlated with LDL-FPG. The two-classification Logistic regression analysis: ages was the risk factor of ABI. The level of AGEs in the critical group (1.4 鈮，

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