【摘要】：目的:探討新診斷1型糖尿病患者胰島功能水平及其影響因素。方法 :選取2010年1月—2015年12月在南京醫(yī)科大學(xué)第一附屬醫(yī)院內(nèi)分泌科住院治療的新診斷1型糖尿病患者105例,測(cè)糖化血紅蛋白、胰島自身抗體及HLA-A和-DR位點(diǎn),控制血糖10 mmol/L后行混合餐試驗(yàn),測(cè)血糖、胰島素及C肽,計(jì)算峰值C肽≥0.2 nmol/L的比例,并采用Logistic回歸分析影響新診斷1型糖尿病患者胰島功能的因素。結(jié)果:89.5%的患者初診時(shí)峰值C肽≥0.2 nmol/L。初診年齡≤18歲(OR=0.08,95%CI:0.01~0.90),酮癥或酮癥酸中毒起病(OR=0.08,95%CI:0.01~0.83),攜帶高危HLA-A-DRB1基因單倍型(OR=0.07,95%CI:0.01~0.61),胰島自身抗體陽(yáng)性數(shù)2(OR=0.10,95%CI:0.01~0.87)者峰值C肽≥0.2 nmol/L率更低。結(jié)論 :1型糖尿病患者初診時(shí)仍有部分胰島功能。因此,胰島功能不能作為鑒別診斷1型或2型糖尿病的唯一依據(jù)。新診斷1型糖尿病患者胰島功能與初診年齡、酮癥或酮癥酸中毒起病、HLA-A-DRB1基因單倍型及胰島自身抗體有關(guān)。
[Abstract]:Objective: to investigate the islet function and its influencing factors in newly diagnosed type 1 diabetes mellitus. Methods: from January 2010 to December 2015, 105 newly diagnosed type 1 diabetic patients were enrolled in the Department of Endocrinology of the first affiliated Hospital of Nanjing Medical University. The glycosylated hemoglobin, islet autoantibodies and HLA-A and Dr sites were measured. After controlling blood glucose for 10 mmol/L, mixed meal test was performed to measure blood glucose, insulin and C-peptide, and the ratio of peak C-peptide 鈮，

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