本文選題：脂肪酸 + 人體組成��； 參考：《浙江大學(xué)》2015年碩士論文

【摘要】：研究目的 隨著肥胖成為日益嚴(yán)重的健康問題,脂肪與脂肪組織含量的測定及分布成為研究熱點(diǎn)。骨骼肌與體內(nèi)的物質(zhì)代謝及能量代謝密切相關(guān)。代謝綜合征是與肥胖相關(guān)的一種常見代謝病,代謝綜合征高患病率使其成為中國的一個嚴(yán)重公共衛(wèi)生問題。本研究旨在以杭州社區(qū)人群為研究對象,從膳食營養(yǎng)的角度通過測定體內(nèi)血漿磷脂脂肪酸、脂肪的分布及代謝綜合征相關(guān)的臨床指標(biāo),并對脂肪酸與脂肪分布相關(guān)指標(biāo)以及代謝綜合征相關(guān)臨床指標(biāo)進(jìn)行分析,以探討人體脂肪酸的構(gòu)成與脂肪分布及代謝綜合征的關(guān)系。 材料與方法 2008-2013年期間在杭州社區(qū)招募108名研究對象,用調(diào)查問卷收集了他們的社會人口學(xué)資料,對他們進(jìn)行了體格測量(身高、體重和腰圍等指標(biāo))、磁共振成像(MRI)測量、血液生化指標(biāo)的測量以及血漿磷脂脂肪酸測量。分別用相關(guān)分析、多元線性回歸分析和二分類Logistic回歸來研究血漿磷脂脂肪酸與人體組成和代謝綜合征的關(guān)聯(lián)性。 研究結(jié)果 本次研究共有102名研究對象符合要求,研究人群的平均年齡為52.10±±12.55歲,其中男性為51.17±13.75歲,女性為53.23±±10.96歲,兩組年齡無統(tǒng)計(jì)學(xué)差異。男性全身VAT、全身MAT、全身Muscle、腹部VAT、腹部IMAT、腹部Muscle、腰圍、收縮壓、舒張壓、空腹血糖、膽固醇明顯較女性高；而全身SAT及腹部SAT在男性人群明顯較女性人群低。男性與女性年齡及BMI上無明顯差異。在脂肪分布等指標(biāo)男性與女性有顯著性差異。男女性間腰圍、收縮壓、舒張壓、空腹血糖存在顯著性差異,甘油三酯、高密度脂蛋白及代謝綜合征患病率無顯著性差異。男性血漿磷脂脂肪酸C17：0、C20：2相對濃度顯著低于女性,C18:3(RLA)、C20:3n3、 C20:4(AA)、C22:4相對濃度顯著高于女性,其他種類脂肪酸男性與女性無統(tǒng)計(jì)學(xué)差異�；貧w分析結(jié)果顯示男性人群中,C14：0與全身肌間脂肪呈正相關(guān),C17：0與全身內(nèi)臟脂肪和全身肌間脂肪呈負(fù)相關(guān),C16:0、C18:0、SFA與骨骼肌呈正相關(guān),在女性人群中,脂肪酸與肌間脂肪及骨骼肌無相關(guān)性。在脂肪酸與代謝綜合征的關(guān)系研究中,C12:0、C20:0、C22:6(DHA)與代謝綜合征呈負(fù)相關(guān),n-6脂肪酸與代謝綜合征無顯著性相關(guān)。 研究結(jié)論 1.男性全身VAT、IMAT、Muscle、腹部VAT、IMAT、Muscle較女性高；男性全身SAT及腹部SAT較女性人群低。 2.男性人群中,C14：0含量越高,全身肌間脂肪越多,C17：0含量越高全身內(nèi)臟脂肪和全身肌間脂肪越少,在女性人群中,脂肪酸與肌間脂肪無相關(guān)性； 3.男性人群中,C16:0、C18:0、SFA含量越高,全身骨骼肌含量越多,攝入飽和脂肪酸可以預(yù)防肌肉減少癥,在女性人群中,脂肪酸與全身骨骼肌無相關(guān)性； 4.C12:0、C20:0、C22:6(DHA)含量越高,代謝綜合征發(fā)病風(fēng)險越低,n-6脂肪酸與代謝綜合征無顯著性相關(guān)。
[Abstract]:Objective with obesity becoming an increasingly serious health problem, the determination and distribution of fat and adipose tissue has become a hot topic. Skeletal muscle is closely related to substance metabolism and energy metabolism. Metabolic syndrome is a common metabolic disease associated with obesity. The high prevalence of metabolic syndrome makes it a serious public health problem in China. The aim of this study was to determine the distribution of plasma phospholipid fatty acids, fatty acids and related clinical indexes of metabolic syndrome from the point of view of dietary nutrition. The relationship between fatty acid and fatty acid distribution and metabolic syndrome was analyzed in order to explore the relationship between fatty acid composition and fat distribution and metabolic syndrome. Materials and methods 108 subjects were recruited in Hangzhou community from 2008 to 2013. The data of their social demographics were collected by questionnaire, and their physiques were measured (height, height). Weight and waist circumference), magnetic resonance imaging (MRI), blood biochemical parameters and plasma phospholipid fatty acids. The correlation between plasma phospholipid fatty acids and body composition and metabolic syndrome was studied by correlation analysis, multivariate linear regression analysis and binary logistic regression. Results A total of 102 subjects met the requirements. The average age of the study population was 52.10 鹵12.55 years old, including 51.17 鹵13.75 years for males and 53.23 鹵10.96 years for females. There was no significant difference in age between the two groups. Vat, Matt, Muscle. abdominal Vat, abdominal IMATT, abdominal Muscle, waist circumference, systolic blood pressure, diastolic blood pressure, fasting blood glucose and cholesterol were significantly higher in men than in women, while whole body SAT and abdominal SAT were significantly lower in males than in females. There was no significant difference in age and BMI between males and females. There was significant difference in fat distribution between male and female. There were significant differences in waist circumference, systolic blood pressure, diastolic blood pressure and fasting blood glucose between men and women, but there was no significant difference in the prevalence of triglyceride, high density lipoprotein and metabolic syndrome. The relative concentrations of plasma phospholipid fatty acids C17: 0 and C20: 2 in males were significantly lower than those in females, and the relative concentrations of C20: 4 (AA) in C20: 4 were significantly higher than those in females. There was no significant difference in other fatty acids between males and females. Regression analysis showed that there was a positive correlation between C14: 0 and systemic muscle fat in male population. C17: 0 was negatively correlated with visceral fat and intermuscular fat. C16: 0 and C180: 0 SFA were positively correlated with skeletal muscle. There was no correlation between fatty acids and intermuscular fat and skeletal muscle. In the study of the relationship between fatty acids and metabolic syndrome, there was a negative correlation between C12: 0, C20: 0, C22: 6 (DHA) and metabolic syndrome. There was no significant correlation between n-6 fatty acids and metabolic syndrome. Conclusion 1. Male VATT IMATT Muscle. abdominal VAT IMATATM muscle is higher than female, male whole body SAT and abdominal SAT are lower than female. 2. 5%. The higher the content of C14: 0 was in male population, the higher the content of C17: 0 was. The higher the content of C17: 0 was, the lower the content of visceral fat and intermuscular fat was, but there was no correlation between fatty acid and intermuscular fat in female population. The higher the content of SFA in male population is, the higher the content of skeletal muscle is, and the higher the content of skeletal muscle is, the higher the content of DHA (DHA) is, the higher the content of SFA is. The lower the risk of metabolic syndrome, the lower the relationship between n-6 fatty acids and metabolic syndrome.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R589

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