本文選題：骨質(zhì)疏松 + 維甲酸�。� 參考：《中國(guó)組織工程研究》2017年20期

【摘要】：背景:骨質(zhì)疏松嚴(yán)重危害老年人的健康和生活質(zhì)量,建立理想的實(shí)驗(yàn)動(dòng)物模型對(duì)骨質(zhì)疏松的病因和治療的研究有著重要的意義。目的:通過(guò)不同劑量的維甲酸誘導(dǎo)建立大鼠骨質(zhì)疏松模型,篩選出理想的造模劑量。方法:將80只雌性SD大鼠按體質(zhì)量隨機(jī)分為對(duì)照組、低劑量組、中劑量組和高劑量組,各20只。低劑量組、中劑量組和高劑量組分別以80,100,120 mg/(kg·d)維甲酸連續(xù)灌胃14 d。結(jié)果與結(jié)論:與對(duì)照組相比,低劑量組大鼠骨密度、成骨細(xì)胞和破骨細(xì)胞計(jì)數(shù)及骨微觀結(jié)構(gòu)無(wú)明顯變化,而中、高劑量組大鼠股骨骨密度、血清鈣含量明顯下降,股骨破骨細(xì)胞數(shù)量增加,骨微觀結(jié)構(gòu)明顯發(fā)生改變,其中以中劑量組最為明顯。結(jié)果說(shuō)明100 mg/(kg·d)維甲酸灌胃14 d可誘導(dǎo)大鼠建立骨質(zhì)疏松模型,且穩(wěn)定性良好。
[Abstract]:Background: osteoporosis is a serious hazard to the health and quality of life of the elderly. It is of great significance to establish an ideal experimental animal model for the study of the etiology and treatment of osteoporosis. Aim: to establish rat model of osteoporosis by different doses of retinoic acid, and to screen out the ideal dose. Methods: 80 female SD rats were randomly divided into control group, low dose group, middle dose group and high dose group. Low, middle and high dose groups were given retinoic acid at 80100120 mg/(kg d for 14 d. Results and conclusion: compared with the control group, the bone mineral density (BMD), osteoblast and osteoclast count and bone microstructure in the low dose group were not significantly changed, while the bone mineral density and serum calcium content in the middle and high dose groups were significantly decreased. The number of osteoclasts of femur increased and the microstructure of bone changed obviously, especially in middle dose group. The results showed that mg/(kg d) retinoic acid could induce osteoporosis model in rats for 14 d and had good stability.
【作者單位】： 廣州中醫(yī)藥大學(xué)第一附屬醫(yī)院創(chuàng)傷骨科;廣州市正骨醫(yī)院骨科;廣州中醫(yī)藥大學(xué);
【基金】：廣東省科技計(jì)劃項(xiàng)目(2014A020212593)~~
【分類(lèi)號(hào)】：R-332;R580

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 賀麗英;孫蘊(yùn);要文娟;潘克h，

本文編號(hào)：2049395