本文選題：CYPA基因 + 多態(tài)性�。� 參考：《中國骨質(zhì)疏松雜志》2017年03期

【摘要】：目的探討CYP11A1基因rs900798位點(diǎn)多態(tài)性與老年性骨質(zhì)疏松性骨折骨轉(zhuǎn)換標(biāo)志物的關(guān)系。方法研究對象為121例老年性骨質(zhì)疏松性骨折患者(骨折組),114例老年性骨質(zhì)疏松癥患者(對照組)。骨折組中胸椎骨折、腰椎骨折、胸腰椎骨折、股骨頸骨折、粗隆間骨折、肱骨近端骨折和橈骨遠(yuǎn)端例數(shù)分別為32例、40例、3例、19例、20例、4例和3例。采用SNa Pshot法進(jìn)行SNP分型,化學(xué)發(fā)光法測定血清Ⅰ型前膠原氨基端前肽(PINP)、Ⅰ型膠原羧基端肽β特殊序列(β-CTX)濃度。計算兩組等位基因頻率、基因型頻率并分析骨折組CYP11A1基因多態(tài)性與PINP、β-CTX的關(guān)系。結(jié)果兩組rs900798位點(diǎn)等位基因基因頻率和基因型頻率分布符合哈迪溫伯格平衡。骨折組和對照組G、T等位基因頻率分別為40.1%、59.9%和38.2%、61.8%,差異無統(tǒng)計學(xué)意義(P0.05);兩組GG、GT、TT基因型頻率分別為14.9%、50.4%、34.7%和13.2%、50.0%、36.8%,差異無統(tǒng)計學(xué)意義(P0.05)。骨折組和對照組血清PINP、β-CTX差異無統(tǒng)計學(xué)意義(P0.05)。骨折組中GG、GT、TT基因型的PINP、β-CTX差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論 CYP11A1基因rs900798位點(diǎn)多態(tài)性與老年性骨質(zhì)疏松性骨折患者血清PINP、β-CTX無相關(guān)性。
[Abstract]:Objective to investigate the relationship between rs900798 polymorphism of CYP11A1 gene and bone turnover markers in senile osteoporosis fracture. Methods 121 cases of senile osteoporotic fracture (fracture group, 114 cases of senile osteoporosis, control group) were studied. In the fracture group, the cases of thoracic vertebral fracture, lumbar vertebra fracture, thoracolumbar vertebrae fracture, femoral neck fracture, intertrochanteric fracture, proximal humerus fracture and distal radius fracture were 32 cases, 40 cases, 3 cases, and 19 cases, 20 cases and 3 cases, respectively. SNP typing was carried out by SNa shot method. The concentration of serum procollagen type I amino terminal prepeptide (PINPX) and type 鈪，

本文編號：2030619