發(fā)布時間：2018-06-16 17:19

  本文選題：甲狀腺激素 + 型糖尿病��； 參考：《中國動脈硬化雜志》2017年09期

【摘要】：目的探討甲狀腺功能正常的2型糖尿病(T2DM)患者甲狀腺激素水平對冠狀動脈病變嚴重程度和心臟功能的影響。方法 415例經(jīng)冠狀動脈造影檢查診斷為冠心病的住院患者按是否合并T2DM分為糖尿病組131例和對照組284例。檢測生物化學(xué)指標(biāo)、甲狀腺激素水平、心臟結(jié)構(gòu)參數(shù)、心功能及頸動脈內(nèi)膜中膜厚度(IMT),并計算Gensini評分;進一步按Gensini評分的三分位數(shù)將糖尿病組分為低分組34例(≤15分)、中分組33例(16~42分)及高分組64例(≥43分),比較上述指標(biāo)。并采用多元線性回歸分析甲狀腺激素與Gensini評分的相關(guān)性。結(jié)果糖尿病組Gensini評分、心率、FBG、Hb A1c、TG、BUN、MPV、IMT、LVDd及LVPWT較對照組顯著升高,而FT3、LVEF顯著降低(P均0.05)。糖尿病各亞組間FT3隨著Gensini評分的增加有下降的趨勢,高分組顯著低于低分組(P0.05)。多元線性回歸分析顯示,Hb A1c、Cr、ALT、TG、LDLC及促甲狀腺激素是Gensini評分的獨立危險因素。TSH與E/A呈負相關(guān)(r=-0.128,P=0.013),FT4與IMT呈正相關(guān)(r=0.113,P0.05)。結(jié)論促甲狀腺激素可作為冠狀動脈病變的一個獨立危險因素。FT3水平雖不與冠心病的嚴重程度獨立相關(guān),但對于低FT3水平的T2DM患者,仍應(yīng)重視其心臟功能的評估。
[Abstract]:Objective to investigate the effect of thyroid hormone level on the severity of coronary artery disease and cardiac function in type 2 diabetes mellitus (T2DM) with normal thyroid function. Methods 415 inpatients with coronary artery disease diagnosed by coronary angiography were divided into diabetes group (131 cases) and control group (284 cases) according to whether they were complicated with T2DM. Biochemical parameters, thyroid hormone level, cardiac structural parameters, cardiac function and carotid intima-media thickness were measured and Gensini score was calculated. According to the three digits of Gensini score, 34 cases of diabetes were divided into low group (鈮，

本文編號：2027500