發(fā)布時間：2018-06-13 04:38

  本文選題：抗神經(jīng)節(jié)苷脂抗體 + 神經(jīng)精神性狼瘡��； 參考：《青島大學》2015年碩士論文

【摘要】：目的研究抗神經(jīng)節(jié)苷脂抗體在神經(jīng)精神狼瘡(NPSLE)患者中的臨床診斷意義,為患者的診斷尋求有效的依據(jù)。方法將2010年1月-2010年6月我院收治的23例系統(tǒng)性紅斑狼瘡患者(SLE)作為本次研究的觀察組,包括神經(jīng)精神性狼瘡(NPSLE)12例與非神經(jīng)精神性狼瘡(非-NPSLE)11例;另外選取10例同期行健康體檢的正常成年人作為本次研究的對照組,對本次研究對象的血清與腦脊液進行分析比較。結(jié)果對照組人員中的血清中抗GM1 Ig G、Ig M水平在系統(tǒng)性紅斑狼瘡患者與正常人之間差異有統(tǒng)計學意義(P0.01);血清中抗GM1 Ig G、Ig M陽性率,在NPSLE均為25.0%,在非-NPSLE均為18.2%,二者在抗體陽性率和水平上差異無統(tǒng)計學意義(P0.05);NPSLE血清抗GM1 Ig G陽性率和水平與血清抗GM1 Ig M陽性率和水平差異無統(tǒng)計學意義(P0.05)。腦脊液中抗GM1 Ig G、Ig M陽性率,在SLE患者均為52.2%,在正常人均為0.0%,二者之間差異有統(tǒng)計學意義(P0.01);腦脊液中抗GM1 Ig G陽性率,在NPSLE為75.0%,在非-NPSLE為27.3%,二者差異有統(tǒng)計學意義(p0.05);腦脊液中抗GM1 Ig M陽性率,在NPSLE為83.3%,在非-NPSLE為18.2%,二者差異有統(tǒng)計學意義(p0.01);NPSLE腦脊液抗GM1 Ig G陽性率和水平與腦脊液抗GM1 Ig M陽性率和水平差異無統(tǒng)計學意義(P0.05)。結(jié)論腦脊液抗GM1抗體檢測可能有助于NPSLE的診斷;NPSLE的損害更可能是鞘內(nèi)局部產(chǎn)生的抗GM1抗體引起,尤其在有中樞神經(jīng)系統(tǒng)損害的患者;抗GM1抗體可能引起NPSLE患者神經(jīng)系統(tǒng)脫髓鞘病變。
[Abstract]:Objective to study the clinical diagnostic significance of anti-ganglioside antibody in patients with neuropsychiatric lupus erythematosus (NPSL). Methods 23 patients with systemic lupus erythematosus treated in our hospital from January 2010 to June 2010 were selected as the observation group, including 12 cases of neuropsychiatric lupus erythematosus and 11 cases of non-neuropsychiatric lupus erythematosus (non-NPSLEL). In addition, 10 healthy adults were selected as the control group, and the serum and cerebrospinal fluid (CSF) of the subjects were analyzed and compared. Results the level of anti-GM1 Ig G G M in the control group was significantly different between the patients with systemic lupus erythematosus (SLE) and the normal controls (P 0.01), and the positive rate of anti-GM1 Ig G G M in serum was significantly higher than that in the control group (P < 0.05). There was no significant difference in antibody positive rate and level between NPSLE and non-NPSLE. There was no significant difference in the positive rate and level of anti-GM1 Ig G between NPSLE and anti-GM1 Ig M. There was no significant difference in the positive rate and level of anti-GM1 Ig G and anti-GM1 Ig M between NPSLE and non-NPSLE (P 0.05). The positive rate of anti-GM1 IgG G M in cerebrospinal fluid was 52.2 in SLE and 0.0in normal controls, the difference was statistically significant (P0.01), the positive rate of anti-GM1 Ig G in cerebrospinal fluid was higher than that in SLE, and the positive rate of anti-GM1 Ig G in cerebrospinal fluid was significantly higher than that in normal controls (P < 0.05). The difference between NPSLE and non-NPSLE was statistically significant (p0.05), and the positive rate of anti-GM1 IgG M in cerebrospinal fluid was significantly higher than that in non-NPSLE. The difference between NPSLE and non-NPSLE was statistically significant (p 0.01). The positive rate and level of anti-GM1 Ig G in cerebrospinal fluid of NPSLE were not significantly different from those of CSF anti-GM1 Ig M (P 0.05). Conclusion the detection of anti-GM1 antibody in cerebrospinal fluid may be helpful to the diagnosis of NPSLE and the damage of NPSLE is more likely to be caused by anti-GM1 antibody produced locally in the sheath, especially in patients with central nervous system damage. Anti-GM 1 antibody may cause demyelinating lesions of nervous system in NPSLE patients.
【學位授予單位】：青島大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：R593.24

【參考文獻】

相關(guān)期刊論文 前2條

1 周廣宇;韓雪梅;金玲;;神經(jīng)精神狼瘡患者影像學表現(xiàn)與自身抗體水平和預后的關(guān)系[J];吉林大學學報(醫(yī)學版);2013年03期

2 陳新光;趙永強;;磷脂抗體綜合征狼瘡抗凝物和血栓臨床相關(guān)性分析[J];哈爾濱醫(yī)科大學學報;2013年04期

，

本文編號：2012750