發(fā)布時(shí)間：2018-06-07 20:46

  本文選題：支氣管哮喘 + 肺功能�。� 參考：《山西醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:探討支氣管哮喘患者治療前后氣道功能的改變及氣道間相關(guān)性分析。方法:采用回顧性分析,選擇2013年3月—2016年6月在山西醫(yī)科大學(xué)第二醫(yī)院門(mén)診就診的53例哮喘患者為研究對(duì)象,入選患者符合支氣管哮喘的診斷標(biāo)準(zhǔn),根據(jù)治療前后肺功能情況將患者分為3組,A組(31例)在治療前后FEV1/預(yù)計(jì)值≥80%,且FEV1/FVC≥70%,B組(10例)在治療前FEV1/預(yù)計(jì)值80%,或FEV1/FVC70%,治療后FEV1/預(yù)計(jì)值≥80%,且FEV1/FVC≥70%,C組(12例)治療前后FEV1/預(yù)計(jì)值80%,且FEV1/FVC70%。治療方案為布地奈德/福莫特羅粉吸入劑160/4.5μg,劑量按GINA指南規(guī)定劑量,治療時(shí)間為6個(gè)月,6個(gè)月后,門(mén)診隨訪并行肺功能檢查。結(jié)果:1、A、B、C三組治療前FEV1/預(yù)計(jì)值、FEV1/FVC、PEF、FEF50%、FEF75%、MMEF差別有統(tǒng)計(jì)學(xué)意義(P0.05);A、B、C三組各組治療6個(gè)月后FEV1/預(yù)計(jì)值、FEV1/FVC、PEF、FEF50%、FEF75%、MMEF均較同組治療前有明顯改善(P0.05);B組治療6個(gè)月后FEV1/預(yù)計(jì)值、FEV1/FVC、FEF50%、FEF75%、MMEF較A組差(P0.05),PEF較A組無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);C組治療6個(gè)月后FEV1/FVC、FEF50%、FEF75%、MMEF較B組差(P0.05),FEV1/預(yù)計(jì)值、PEF較B組無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。2、A組治療前,11例(35.5%)小氣道功能正常,20例(64.5%)小氣道功能障礙。治療后,15例(48.4%)小氣道功能正常,16例(51.6%)小氣道功能障礙;B組、C組治療前后,小氣道功能均不正常。3、Pearson相關(guān)性結(jié)果示FEV1/預(yù)計(jì)值、FEV1/FVC和PEF與小氣道各項(xiàng)指標(biāo)間均具有正相關(guān),且FEV1/預(yù)計(jì)值、FEV1/FVC與小氣道各項(xiàng)指標(biāo)均密切相關(guān)。結(jié)論:1、吸入型ICS/LABA,對(duì)改善哮喘患者的肺功能有良好的效果。2、哮喘患者FEV1正常仍然可以有小氣道功能障礙。3、FEV1、FEV1/FVC與小氣道各項(xiàng)指標(biāo)間均具有正相關(guān),且相關(guān)性顯著。
[Abstract]:Objective: to investigate the changes of airway function and the correlation between airway in patients with bronchial asthma before and after treatment. Methods: by retrospective analysis, 53 patients with asthma were selected from March 2013 to June 2016 in the second Hospital of Shanxi Medical University as study subjects. The patients were selected to meet the diagnostic criteria of bronchial asthma. According to the pulmonary function before and after treatment, the patients were divided into three groups: FEV1 / predicted value 鈮，

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