本文選題：趨化因子Fractalkine + 糖尿病　； 參考：《中國(guó)糖尿病雜志》2017年11期

【摘要】：目的探討血清Fractalkine(FKN)因子水平與肥胖和T2DM的相關(guān)性。方法根據(jù)BMI將88名健康體檢者即糖耐量正常者(NGT)分為體重正常組(A組,n=44,BMI24kg/m~2)和超重肥胖組(B組,n=44,BMI≥24kg/m~2);將88例新診斷T2DM患者(T2DM組)分為體重正常組(C組,n=44,BMI24kg/m~2)和超重肥胖組(D組,n=44,BMI≥24kg/m~2)。ELISA測(cè)定FKN和腫瘤壞死因子α(TNF-α)水平。結(jié)果 T2DM患者FKN(0.625±0.090)ng/ml高于NGT者(0.395±0.110)ng/ml(P0.01),C組FKN(0.55±0.08)ng/ml高于A組(0.34±0.14)ng/ml和B組(0.45±0.08)ng/ml(P0.01)。T2DM患者FKN與FPG、HbAlc、WHR、BMI、C-RP、HOMA-IR、TNF-α呈正相關(guān)(r=0.578、0.592、0.616、0.596、0.909、0.872和0.827,P0.01),與HDL-C呈負(fù)相關(guān)(r=-0.216,P0.05)。多元回歸分析顯示,C-RP、BMI及TNF-α是FKN的獨(dú)立相關(guān)因素(β=0.441、0.158和0.221,P0.05)。結(jié)論 T2DM患者FKN與炎癥反應(yīng)密切相關(guān),可能參與了肥胖及T2DM的發(fā)生發(fā)展。
[Abstract]:Objective to investigate the relationship between serum Fractalkinesia FKN and obesity and T2DM. Methods according to BMI, 88 healthy persons with normal glucose tolerance were divided into two groups: normal body weight group (group A, n = 4) and overweight group (group B, n = 44 BMI 鈮，

本文編號(hào)：1984937