本文選題：達格列凈 + 鈉-葡萄糖其轉運蛋白抑制劑��； 參考：《沈陽藥科大學學報》2017年10期

【摘要】：目的系統(tǒng)評價鈉-葡萄糖共轉運蛋白2(sodium-dependent glucose transporter 2,SGLT-2)抑制劑達格列凈治療2型糖尿病(type 2 diabetes,T2DM)患者的有效性和安全性。方法計算機檢索Pub Med、The Cochrane Library、EMbase、中國知網和萬方數據庫,檢索時限截止至2016年3月,由兩名研究者分別對納入文獻進行數據提取與質量評價后,采用Rev Man 5.3和Stata12.0軟件進行Meta分析。結果納入19個隨機對照試驗,共8 618例患者。Meta分析結果顯示,與安慰劑相比,達格列凈組患者糖化血紅蛋白(hemoglobin A1c,Hb A1c)水平降低[WMD=-0.49,95%CI(-0.65,-0.34),P0.001];體重減輕[(WMD=-1.84 kg,95%CI(-2.09,-1.59),P0.001];收縮壓[WMD=-3.07,95%CI(-3.92,-2.23),P0.001]和舒張壓[WMD=-1.66,95%CI(-2.30,-1.01),P0.001]均有所下降,總不良反應發(fā)生率比較差異無統(tǒng)計學意義[RR=1.10,95%CI(0.99,1.22),P=0.09];低血糖發(fā)生率比較差異無統(tǒng)計學意義[RR=1.10,95%CI(0.99,1.24),P=0.09];泌尿系感染發(fā)生率比較差異無統(tǒng)計學意義[RR=1.09,95%CI(0.92,1.29),P=0.34];腎功能損傷發(fā)生率[RR=1.78,95%CI(1.04,3.05),P=0.03]以及生殖系感染發(fā)生率[RR=3.27,95%CI(2.39,4.47),P0.001]均增高。結論達格列凈雖增加生殖系感染發(fā)生率及腎功能損傷發(fā)生率,但能有效降低T2DM患者Hb A1c水平、體重和血壓,影響血脂水平,不良反應發(fā)生率、低血糖發(fā)生率和泌尿系感染的發(fā)生率與安慰劑相當。
[Abstract]:Objective to evaluate the efficacy and safety of sodium glucose cotransporter (2(sodium-dependent glucose transporter 2) SGLT-2 inhibitor Daglitrine in the treatment of type 2 diabetes mellitus (T2DM). Methods the Cochrane Library EMbase, China knowledge Network and Wanfang database were searched by computer. The retrieval time was up to March 2016. After data extraction and quality evaluation were carried out by two researchers respectively, Meta-analysis was carried out by Rev Man 5.3 and Stata12.0 software. 緇撴灉綰沖叆19涓殢鏈哄鐓ц瘯楠，

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