本文選題：卡托普利 + 美托洛爾　； 參考：《中國地方病防治雜志》2016年02期

【摘要】：目的比較卡托普利與美托洛爾治療慢型克山病的臨床療效及對患者心臟功能的影響。方法選擇2014年1月~2015年12月在本院治療的慢性克山病患者64例,根據(jù)隨機數(shù)字表分為卡托普利組(n=32)和美托洛爾組(n=32)。兩組患者均進行常規(guī)基礎(chǔ)治療,卡托普利組在基礎(chǔ)治療的基礎(chǔ)上應(yīng)用卡托普利,美托洛爾組在基礎(chǔ)治療措施的基礎(chǔ)上使用美托洛爾。治療后分別對兩組患者死亡情況,臨床癥狀改善情況以及心功能改善情況進行評估。結(jié)果卡托普利組病死率為3.13%,美托洛爾組無死亡。美托洛爾組治療后心悸發(fā)生率顯著高于卡托普利組(χ2=5.411,P0.05);卡托普利組治療后氣促和咳嗽發(fā)生率均顯著高于美托洛爾組(P0.05)。治療后兩組患者心動過速、口唇發(fā)紺、以及浮腫等體征的發(fā)生率均較治療前顯著降低(P0.05)。治療后兩組患者LVESD和LVEDD均較治療前顯著降低(P0.05),LVEF均較治療前顯著升高(P0.05)。組間比較,治療前后兩組患者LVESD,LVEF和LVEDD比較差異均無統(tǒng)計學(xué)意義(P0.05)。組間比較,治療前后兩組患者心功能分級比較差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論卡托普利和美托洛爾均可顯著改善慢型克山病患者心功能,緩解臨床癥狀,但兩種藥物對部分臨床癥狀的緩解作用存在差異。
[Abstract]:Objective to compare the effect of captopril and metoprolol on chronic Keshan disease. Methods Sixty-four patients with chronic Keshan disease treated in our hospital from January 2014 to December 2015 were randomly divided into captopril group (n = 32) and metoprolol group (n = 32). The patients in the captopril group were treated with captopril and the metoprolol group were treated with metoprolol on the basis of the basic treatment. After treatment, the death, clinical symptoms and cardiac function of the two groups were evaluated. Results the mortality of captopril group was 3.13%, and that of metoprolol group was not. The incidence of palpitation in the metoprolol group was significantly higher than that in the captopril group (蠂 ~ 2 = 5.411), and the incidence of shortness of breath and cough in the captopril group was significantly higher than that in the metoprolol group (P 0.05). After treatment, the incidence of tachycardia, cyanosis of lips and swelling in both groups were significantly lower than those before treatment. After treatment, LVESD and LVEDD in both groups were significantly lower than those before treatment. There was no significant difference in LVEF and LVEDD between the two groups before and after treatment (P 0.05). There was no significant difference in cardiac function between the two groups before and after treatment (P 0.05). Conclusion Captopril and metoprolol can significantly improve cardiac function and relieve clinical symptoms in patients with chronic Keshan disease.
【作者單位】： 遼寧省鞍山市腫瘤醫(yī)院藥劑科;
【分類號】：R542.3

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