微波、射頻及激光在離體豬甲狀腺消融實(shí)驗(yàn)的對(duì)比研究
發(fā)布時(shí)間:2018-06-01 00:05
本文選題:甲狀腺 + 消融技術(shù); 參考:《中國(guó)普通外科雜志》2016年05期
【摘要】:目的:在離體豬甲狀腺組織上比較微波消融(MWA)、射頻消融(RFA)、激光消融(LA)的消融特性和溫度變化,為臨床制定消融方案提供參考。方法:將150個(gè)新鮮離體豬甲狀腺均分為3組,分別行MWA(20 W 5 min)、RFA(5 W)、LA(3 W 1200 J),各組消融同時(shí)在靶心處進(jìn)行實(shí)時(shí)測(cè)溫和超聲觀察,消融結(jié)束后沿針道剖開(kāi),觀察消融灶形態(tài),計(jì)算消融灶體積并進(jìn)行病理學(xué)檢查。結(jié)果:3組間比較,MWA組消融體積最大(1 597.09 mm~3),LA組次之(780.89 mm~3),RFA組最小(162.20 mm~3),差異均有統(tǒng)計(jì)學(xué)意義(均P0.05)。MWA及RFA溫升曲線陡直,而LA溫升曲線平緩,但最高溫度最高(200.9℃)。RFA組消融區(qū)域組織分布均勻,未見(jiàn)到明顯的炭化和氣化空腔;MWA組消融區(qū)域可見(jiàn)碳化,但無(wú)明顯氣化空腔;LA組消融灶中央可見(jiàn)碳化與氣化空腔。消融灶由內(nèi)向外,RFA組為凝固壞死區(qū)、充血反應(yīng)區(qū);MWA組為炭化區(qū)、凝固壞死區(qū)及充血反應(yīng)區(qū);LA組為氣化空腔區(qū)、炭化區(qū)、凝固壞死區(qū)及充血反應(yīng)區(qū)。結(jié)論:MWA、RFA及LA的消融范圍、溫升曲線及消融區(qū)病理變化存在差異,了解各自的消融特點(diǎn)有利于3種消融技術(shù)的合理應(yīng)用。
[Abstract]:Objective: to compare the characteristics and temperature changes of microwave ablation (MWA), radiofrequency ablation (RFAA) and laser ablation (LAA) in pig thyroid tissue in vitro. Methods: 150 fresh isolated pig thyroid glands were divided into 3 groups. MWA(20 W 5 min and RFAA 5 WCA 3 W 1200 J / L were performed respectively. The ablation was performed simultaneously in the target site with real-time temperature measurement and ultrasound observation. After ablation, the ablation focus was dissected along the needle canal to observe the morphology of the ablation focus. The volume of ablation was calculated and pathological examination was performed. Results the largest ablation volume (1 597.09 mm) in the P0.05).MWA group was higher than that in the LA group (780.89 mm). The difference was statistically significant (all the P0.05).MWA and RFA temperature rise curves were steeper than those in the LA group). However, the highest temperature was 200.9 鈩,
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