本文選題：限能量平衡膳食 + 超重或肥胖多囊卵巢綜合征�。� 參考：《中國實用內(nèi)科雜志》2017年05期

【摘要】：目的回顧性分析限能量平衡膳食(CRD)對超重或肥胖多囊卵巢綜合征(PCOS)患者體成分和代謝指標的影響。方法回顧分析南京大學醫(yī)學院附屬鼓樓醫(yī)院收治的59例體重指數(shù)(BMI)≥24的PCOS經(jīng)CRD干預前后的數(shù)據(jù),測定了體成分、血脂、75 g口服葡萄糖耐量實驗和同步胰島素釋放試驗,并計算穩(wěn)態(tài)模型評估胰島素抵抗指數(shù)(HOMA-IR)。采用配對t檢驗和McNemar卡方檢驗比較分析。結(jié)果經(jīng)12周干預,患者體重下降(7.21±3.76)kg(9.05%),體脂肪(BF)、體脂百分比(BFP)和內(nèi)臟脂肪面積(VFA)分別下降16.15%、8.00%和12.59%,腰圍(WC)減少(7.00±4.12)cm(6.96%)、腰臀比(WHR)下降3.16%(P均0.001);總膽固醇(TC)、低密度脂蛋白膽固醇(LDL-C)、三酰甘油(TG)、胰島素0 min和120 min均顯著下降(P均0.05)。胰島素抵抗(IR,定義為HOMA-IR≥2.69)檢出率由干預前89.83%降至干預后54.55%,代謝綜合征(MS)的檢出率由干預前67.80%降至干預后42.37%。結(jié)論超重或肥胖PCOS患者經(jīng)CRD干預可以減輕體重、BF、VFA,并改善脂代謝紊亂、IR和MS。
[Abstract]:Objective to analyze the effects of energy limited balanced diet (CRD) on body composition and metabolic indexes of overweight or obese polycystic ovary syndrome (PCOS). Methods the data of 59 cases of PCOS with CRD or more than 24 of body mass index (BMI) in the Affiliated Drum Tower Hospital of Nanjing University medical college were analyzed. The body composition, blood lipid, and 75 g oral Portuguese were measured. The glucose tolerance test and simultaneous insulin release test were used to evaluate the insulin resistance index (HOMA-IR). The paired t test and the McNemar chi square test were used to compare the results. The results showed that the weight loss (7.21 + 3.76) kg (9.05%), body fat (BF), body fat percentage (BFP) and visceral fat area (VFA) decreased by 16.15 after 12 weeks of intervention. %, 8% and 12.59%, WC decreased (7 + 4.12) cm (6.96%), waist to hip ratio (WHR) decreased 3.16% (P 0.001); total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), three glycerol (TG), insulin 0 min and 120 min (P mean 0.05). Insulin resistance (IR, HOMA-IR > 2.69) was reduced from 89.83% before intervention to intervention after intervention. 55%, the detection rate of metabolic syndrome (MS) was reduced from 67.80% to intervention before intervention and 42.37%. conclusion overweight or obese PCOS patients with CRD intervention can reduce weight, BF, VFA, and improve lipid metabolism disorders, IR and MS.
【作者單位】： 南京大學醫(yī)學院附屬鼓樓醫(yī)院;北京協(xié)和醫(yī)院;
【基金】：南京市衛(wèi)生局科技發(fā)展項目(YKK13075)
【分類號】：R711.75

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