本文選題：直腸癌 + 型糖尿病��； 參考：《中國老年學雜志》2016年21期

【摘要】：目的探討血清肝細胞生長因子(HGF)、糖化血紅蛋白(Hb A1c)水平對老年直腸癌伴2型糖尿病(T2DM)患者行Dixon術后吻合口瘺發(fā)生情況的影響。方法接受Dixon術治療的老年直腸癌伴T2DM患者34例作為觀察組,31例行Dixon術的老年直腸癌不伴T2DM患者作為對照組。比較兩組術中及術后情況。結果觀察組血清HGF(t=6.673,P0.001)、Hb A1c(t=8.114,P0.001)的水平均高于對照組(P0.05);觀察組術后住院時間(t=3.559,P=0.001)、術后吻合口瘺的發(fā)生率(χ~2=3.947,P=0.047)均大于對照組(P0.05);觀察組術后2年累積生存率明顯低于對照組(44.12%,15/34 vs 80.65%,25/31;Log-rankχ~2=6.050,P=0.014)。結論降低老年直腸癌伴T2DM患者的血清HGF、Hb A1c水平,可以有效減少老年患者Dixon術后吻合口瘺的發(fā)生,改善老年患者的術后恢復情況。
[Abstract]:Objective to investigate the effect of serum HGF, HbA1c on the occurrence of anastomotic fistula after Dixon in elderly patients with rectal cancer with type 2 diabetes mellitus (T2DM). Methods 34 cases of elderly rectal cancer with T2DM treated by Dixon were used as control group. 31 cases of elderly rectal cancer without T2DM were treated with Dixon operation as control group. The intraoperative and postoperative conditions were compared between the two groups. Results the levels of serum HGFA1cTX 8.114P0.001 in the observation group were higher than those in the control group (P 0.001), and the postoperative hospitalization time and the incidence of postoperative anastomotic fistula in the observation group were significantly higher than those in the control group (蠂 23.947P0.047), and the 2 year cumulative survival rate in the observation group was significantly lower than that in the control group (44.12 / 1534 vs 80.25 / 31P / P 0.014). Conclusion the decrease of serum HGF HbA1c level in elderly patients with T2DM can effectively reduce the occurrence of anastomotic fistula and improve the postoperative recovery of elderly patients with Dixon.
【作者單位】： 沈陽醫(yī)學院附屬中心醫(yī)院普外四科;沈陽醫(yī)學院附屬中心醫(yī)院放射線科;
【分類號】：R735.37;R587.1
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本文編號：1938798