本文選題：2型糖尿病 + 結(jié)腸癌�。� 參考：《廣西醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:研究合并T2DM的結(jié)腸癌患者的年齡、性別、高血壓情況、TNM分期、腫瘤浸潤程度、淋巴轉(zhuǎn)移、遠(yuǎn)處轉(zhuǎn)移與單純結(jié)腸癌患者有無區(qū)別,并了解合并T2DM的結(jié)腸癌組織中EMT相關(guān)蛋白E-cadherin(上皮細(xì)胞鈣粘蛋白)、MMP9(基質(zhì)金屬蛋白酶9)的表達(dá)情況。方法:收集2004年1月-2010年6月在廣西醫(yī)科大學(xué)第一附屬醫(yī)院病理科診斷為單純結(jié)腸癌患者48例,經(jīng)病理科及臨床醫(yī)師共同診斷為合并T2DM的結(jié)腸癌患者40例,收集2015年5月-2017年4月在廣西醫(yī)科大學(xué)第九附屬醫(yī)院病理科診斷為單純結(jié)腸癌患者27例,經(jīng)病理科及臨床醫(yī)師共同診斷為合并T2DM的結(jié)腸癌患者19例,并收集病人的年齡、性別、高血壓情況、TNM分期、腫瘤浸潤程度、淋巴轉(zhuǎn)移、遠(yuǎn)處轉(zhuǎn)移的數(shù)據(jù)。運(yùn)用SPSS13.0統(tǒng)計(jì)軟件進(jìn)行分析。從廣西醫(yī)科大學(xué)第一附屬醫(yī)院收集到的病例中使用Excel隨機(jī)數(shù)列法隨機(jī)選出單純結(jié)腸癌患者35例,合并T2DM的結(jié)腸癌患者35例,另收集同時(shí)期病理科診斷為單純結(jié)腸腺瘤患者35例,運(yùn)用免疫組織化學(xué)的方法檢測(cè)各組標(biāo)本中的E-cadherin、MMP9的表達(dá)情況。結(jié)果:1.合并T2DM的結(jié)腸癌患者的年齡比單純結(jié)腸癌患者大。2.單純結(jié)腸癌患者與合并T2DM的結(jié)腸癌的患者的浸潤程度有統(tǒng)計(jì)學(xué)差異,兩者均以T3-T4為主,其中單純結(jié)腸癌患者T3-T4占66.67%,合并T2DM的結(jié)腸癌患者T3-T4占83.05%。3.合并T2DM的結(jié)腸癌患者比單純結(jié)腸癌患者更易合并高血壓(X2=25.382,P=0.000)。4.E-cadherin在單純結(jié)腸腺瘤組、單純結(jié)腸癌組及合并T2DM的結(jié)腸癌組的表達(dá)中,組間有統(tǒng)計(jì)學(xué)差異,但對(duì)三組進(jìn)行兩兩比較均無統(tǒng)計(jì)學(xué)差異。5.MMP9在單純結(jié)腸腺瘤組、單純結(jié)腸癌組及合并T2DM的結(jié)腸癌組的表達(dá)中,組間有統(tǒng)計(jì)學(xué)差異。單純結(jié)腸腺瘤與單純結(jié)腸癌、合并T2DM的結(jié)腸癌兩兩比較均有統(tǒng)計(jì)學(xué)差異,但單純結(jié)腸癌與合并T2DM的結(jié)腸癌之間兩兩比較無統(tǒng)計(jì)學(xué)差異。結(jié)論:1.合并T2DM的結(jié)腸癌的患者的年齡較單純結(jié)腸癌患者高。2.合并T2DM的結(jié)腸癌患者侵襲能力較單純結(jié)腸癌患者更強(qiáng)。3.合并T2DM的結(jié)腸癌患者與單純結(jié)腸癌患者相比,更易合并高血壓。4.MMP9可能是區(qū)分單純結(jié)腸腺瘤與單純結(jié)腸癌的指標(biāo)。5.T2DM影響結(jié)腸癌發(fā)生發(fā)展的過程可能不依賴于E-cadherin、MMP9的作用。
[Abstract]:Objective: to study the age, sex, hypertension stage, tumor invasion, lymphatic metastasis and distant metastasis of colon cancer patients with T2DM. To investigate the expression of E-cadherin (E-cadherin) in human colon carcinoma with T2DM. Methods: from January 2004 to June 2010, 48 patients with simple colon cancer were diagnosed in the Department of Pathology of the first affiliated Hospital of Guangxi Medical University, and 40 patients with T2DM were diagnosed by pathologists and clinicians. From May 2015 to April 2017, 27 patients with simple colon cancer were diagnosed in the Department of Pathology of the Ninth affiliated Hospital of Guangxi Medical University, and 19 patients with T2DM were diagnosed by pathologists and clinicians. The age and sex of the patients were also collected. Data of TNM staging, tumor invasion, lymphatic metastasis and distant metastasis in hypertension. SPSS13.0 statistical software was used to analyze. From the first affiliated Hospital of Guangxi Medical University, 35 patients with simple colon cancer, 35 patients with T2DM and 35 patients with simple adenoma of colon were randomly selected by Excel random sequence method, and 35 patients were diagnosed as simple adenoma of colon by pathology in the same period. The expression of E-cadherinus MMP9 was detected by immunohistochemical method. The result is 1: 1. Colon cancer patients with T2DM are older than those with colon cancer alone. There was a significant difference in the degree of infiltration between the patients with simple colon cancer and those with T2DM. T3-T4 was the main type of infiltration between the two groups. T3-T4 was 66.67 in patients with simple colon cancer, and T3-T4 was 83.05.3. in patients with T2DM, there was a significant difference in the degree of infiltration between patients with simple colon cancer and those with T2DM. Colon cancer patients with T2DM were more likely to be complicated with hypertension than those with simple colon cancer. The expression of E-cadherin in colon adenoma group, colon cancer group and colon cancer group with T2DM was significantly higher than that in simple colon adenoma group, simple colon cancer group and colon cancer group with T2DM. However, there was no significant difference in the expression of MMP9 between the three groups. 5. There was a significant difference in the expression of MMP9 between the three groups in simple colon adenoma group, simple colon cancer group and colon cancer group with T2DM. There was statistical difference between simple colon adenoma and simple colon cancer and colon cancer with T2DM, but there was no statistical difference between simple colon cancer and colon cancer with T2DM. Conclusion 1. Colon cancer patients with T2DM were older than those with colon cancer alone. Colon cancer patients with T2DM were more aggressive. 3. 3 than patients with simple colon cancer. Compared with simple colon cancer patients, patients with T2DM are more likely to be complicated with hypertension. 4. MMP9 may be an index to distinguish simple colon adenoma from simple colon cancer. 5. T2DM may not depend on the role of E-cadherin MMP9 in the development of colon cancer.
【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R587.1;R735.35

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