本文選題：25-羥維生素D3 + 周圍神經(jīng)病變�。� 參考：《重慶醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:研究血清25羥維生素D3[25-hydroxy vitamin D3,25(OH)D3]水平與老年2型糖尿病(type 2 diabetes mellitus,T2DM)周圍神經(jīng)病變的相關(guān)性。方法:收集老年T2DM住院患者150例,根據(jù)有無合并周圍神經(jīng)病變分為糖尿病合并周圍神經(jīng)病變(Diabetic peripheral neuropathy,DPN)組89例和糖尿病不伴周圍神經(jīng)病變(None diabetic peripheral neuropathy,NDPN)組61例。收集所有患者臨床資料,抽取受試者空腹血采用化學(xué)發(fā)光法檢測25(OH)D3水平。結(jié)果:DPN組較NDPN組患者維生素D3缺乏發(fā)生率分別是88.76%和66.85%,差異有統(tǒng)計學(xué)意義(P0.01);DPN組血清25(OH)D3(11.89±6.26)ng/ml低于NDPN組(17.05±6.14)ng/ml,差異有統(tǒng)計學(xué)意義(P0.001);DPN組的年齡、病程、FPG、Hb A1C、TC和LDL-C均高于NDPN組,差異有統(tǒng)計學(xué)意義(P0.05)。25(OH)D3水平與病程、Hb A1C、UACR呈負相關(guān)(P0.05)。Logistic回歸分析結(jié)果顯示:25(OH)D3與DPN的發(fā)生呈負相關(guān),是DPN的保護因素,病程和Hb A1C與DPN的發(fā)生呈正相關(guān),是DPN的危險因素。結(jié)論:25(OH)D3水平下降與老年T2DM伴周圍神經(jīng)病變患者的發(fā)生密切相關(guān),補充維生素D是否能延緩DPN進展或緩解DPN患者臨床癥狀仍需進一步探索。
[Abstract]:Objective: to study the relationship between serum 25-hydroxy vitamin D 3 and type 2 diabetes mellitus type 2 diabetes mellitusus T2DM peripheral neuropathy. Methods: one hundred and fifty elderly patients with T2DM were divided into diabetic peripheral neuropathy group (n = 89) and diabetic peripheral neuropathy group (n = 61) according to the presence or absence of peripheral neuropathy. Clinical data of all patients were collected and fasting blood samples were collected to detect 25(OH)D3 level by chemiluminescence. Results the incidence of vitamin D _ 3 deficiency in the NDPN group was 88.76% and 66.85%, respectively. The difference was statistically significant (P < 0.01). The serum 25(OH)D3(11.89 鹵6.26)ng/ml was significantly lower than that in the NDPN group (17.05 鹵6.14 ng / ml). There was a negative correlation between the level of P0.05OHN D3 and the UACR of HbA1CU. Logistic regression analysis showed that the incidence of DPN was negatively correlated with the incidence of DPN, and was a protective factor of DPN. The course of disease and the occurrence of HB A1C were positively correlated with the occurrence of DPN and the risk factor of DPN. Conclusion the decrease of OH3 level in the aged patients with T2DM with peripheral neuropathy is closely related to the decline of OH3 level. Whether vitamin D supplementation can delay the progression of DPN or alleviate the clinical symptoms of DPN patients should be further explored.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R587.2

【參考文獻】

相關(guān)期刊論文 前6條

1 Kamal AS Al-Shoumer;Thamer M Al-Essa;;Is there a relationship between vitamin D with insulin resistance and diabetes mellitus?[J];World Journal of Diabetes;2015年08期

2 董琪;李全民;;糖尿病周圍神經(jīng)病變發(fā)病機制的研究進展[J];現(xiàn)代儀器與醫(yī)療;2015年02期

3 Federico Carbone;Fran?ois Mach;Nicolas Vuilleumier;Fabrizio Montecucco;;Potential pathophysiological role for the vitamin D deficiency in essential hypertension[J];World Journal of Cardiology;2014年05期

4 高倩;劉揚;;中國人群維生素D缺乏研究進展[J];中國公共衛(wèi)生;2012年12期

5 張增利;李冰燕;王小慧;周正宇;童建;苗登順;;維生素D缺乏導(dǎo)致小鼠糖代謝異常[J];中國糖尿病雜志;2007年12期

6 黃秋菊;李玉蘭;;糖尿病周圍神經(jīng)病變的早期診斷[J];海南醫(yī)學(xué);2006年05期

，

本文編號：1909826