本文選題：普羅布考 + 型糖尿病��； 參考：《重慶醫(yī)學(xué)》2016年31期

【摘要】：目的探討普羅布考對(duì)2型糖尿病患者踝肱指數(shù)和頸動(dòng)脈粥樣硬化斑塊的影響。方法將228例2型糖尿病患者分為兩組,對(duì)照組114例采用阿托伐他汀治療,觀察組114例采用阿托伐他汀聯(lián)合普羅布考治療,比較兩組的治療效果。結(jié)果治療后,兩組血脂(總膽固醇、三酰甘油、低密度脂蛋白膽固醇)、頸動(dòng)脈超聲(頸動(dòng)脈內(nèi)膜中層厚度、內(nèi)膜斑塊面積、易損斑塊檢出率)降低(P0.05),高密度脂蛋白膽固醇(HDL-C)、踝肱指數(shù)(左脛后動(dòng)脈、右脛后動(dòng)脈、左足背動(dòng)脈、右足背動(dòng)脈)增加(P0.05)。觀察組血脂(總膽固醇、三酰甘油、低密度脂蛋白膽固醇)、頸動(dòng)脈超聲(頸動(dòng)脈內(nèi)膜中層厚度、內(nèi)膜斑塊面積、易損斑塊檢出率)低于對(duì)照組(P0.05),HDL-C、踝肱指數(shù)(左脛后動(dòng)脈、右脛后動(dòng)脈、左足背動(dòng)脈、右足背動(dòng)脈)高于對(duì)照組(P0.05)。兩組不良反應(yīng)比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論普羅布考可提高2型糖尿病患者踝肱指數(shù),降低血脂水平,減輕頸動(dòng)脈粥樣硬化斑塊,安全性較高。
[Abstract]:Objective to investigate the effects of Probucol on ankle brachial index (malleolus index) and carotid atherosclerotic plaque (carotid plaque) in type 2 diabetic patients. Methods 228 patients with type 2 diabetes were divided into two groups: the control group (n = 114) treated with Atto vastatin and the observation group (n = 114) treated with Atto vastatin combined with probucol. Results after treatment, two groups of blood lipids (total cholesterol, triglyceride, low density lipoprotein cholesterol), carotid artery ultrasound (carotid intima-media thickness, intimal plaque area, The detection rate of vulnerable plaques decreased P0.05A, HDL-CU, malleolus brachial index (left posterior tibial artery, right posterior tibial artery, left dorsal foot artery, right dorsal foot artery) increased P 0.05. The blood lipids (total cholesterol, triglyceride, low density lipoprotein cholesterol), carotid ultrasound (carotid intima-media thickness, intimal plaque area, vulnerable plaque detection rate) in the observation group were lower than those in the control group (P 0.05) HDL-C, ankle brachial index (left posterior tibial artery). The right posterior tibial artery, left dorsal foot artery and right dorsal foot artery were higher than those of the control group (P 0.05). There was no significant difference in adverse reactions between the two groups (P 0.05). Conclusion Probucol can increase ankle brachial index, decrease blood lipid level and reduce carotid atherosclerotic plaque in type 2 diabetic patients.
【作者單位】： 河北省唐山市人民醫(yī)院神經(jīng)內(nèi)科;河北省唐山市人民醫(yī)院神經(jīng)外科;河北省唐山市人民醫(yī)院超聲科;
【分類號(hào)】：R587.1
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本文編號(hào)：1896228