本文選題：腦出血 + 遲發(fā)性腦水腫��； 參考：《山東醫(yī)藥》2017年02期

【摘要】：目的觀察高血壓合并糖尿病患者腦出血后遲發(fā)性腦水腫與血清基質(zhì)金屬蛋白酶9(MMP-9)水平的關(guān)系。方法 115例高血壓合并糖尿病腦出血患者,根據(jù)患者有無(wú)發(fā)生遲發(fā)性腦水腫分為腦水腫組和無(wú)腦水腫組。采用酶聯(lián)免疫吸附法于入院時(shí)測(cè)定所有患者血清MMP-9,采用多田式公式計(jì)算腦水腫體積,采用Pearson相關(guān)分析、多重線性回歸分析分析血清MMP-9水平與遲發(fā)性腦水腫患者水腫體積的關(guān)系。結(jié)果腦水腫組、無(wú)腦水腫組血清MMP-9水平分別為(139.6±20.3)、(119.8±20.4)μg/L,兩組比較P0.05。Pearson相關(guān)分析顯示,血清MMP-9水平與遲發(fā)性腦水腫患者水腫體積呈正相關(guān)(r=0.46,P0.05);多重線性回歸分析結(jié)果顯示,血清MMP-9水平與遲發(fā)性腦水腫患者水腫體積仍呈正相關(guān)(β=0.19,t=2.13,P0.05)。結(jié)論高血壓合并糖尿病腦出血后發(fā)生遲發(fā)性腦水腫患者血清MMP-9水平升高,患者血清MMP-9水平越高水腫體積越大。
[Abstract]:Objective to investigate the relationship between serum matrix metalloproteinase 9 (MMP-9) and delayed cerebral edema after intracerebral hemorrhage in patients with hypertension and diabetes mellitus. Methods 115 patients with hypertension complicated with diabetic intracerebral hemorrhage were divided into brain edema group and anencephalic edema group according to the occurrence of delayed cerebral edema. Serum MMP-9 was measured by enzyme-linked immunosorbent assay (Elisa). The volume of brain edema was calculated by multi-field formula. The relationship between serum MMP-9 level and edema volume in patients with delayed cerebral edema was analyzed by Pearson correlation analysis and multiple linear regression analysis. Results the serum MMP-9 levels in cerebral edema group and non-brain edema group were 139.6 鹵20.3 鹵20.4 渭 g / L, respectively. Compared with P0.05.Pearson correlation analysis, the serum MMP-9 level was positively correlated with edema volume of delayed cerebral edema patients (P 0.05), and multiple linear regression analysis showed that serum MMP-9 level was positively correlated with edema volume in patients with delayed cerebral edema. There was still a positive correlation between serum MMP-9 level and edema volume in patients with delayed cerebral edema. Conclusion the level of serum MMP-9 in patients with delayed cerebral edema after hypertension complicated with diabetic intracerebral hemorrhage is increased. The higher the level of serum MMP-9 is, the larger the volume of edema is.
【作者單位】： 唐山市工人醫(yī)院;華北理工大學(xué)基礎(chǔ)醫(yī)學(xué)院;
【分類號(hào)】：R743.34;R544.1;R587.1

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 張勝;李煌;;白蛋白治療遲發(fā)性腦水腫1例報(bào)告[J];中國(guó)實(shí)用醫(yī)藥;2007年32期

2 李琳;吳環(huán)立;;遲發(fā)性腦水腫26例護(hù)理體會(huì)[J];河南外科學(xué)雜志;2008年02期

3 吳環(huán)立;聶勤哲;;遲發(fā)性腦水腫的臨床及誤診因素分析(附26例報(bào)告)[J];河南外科學(xué)雜志;2008年02期

4 朱繼人;孫巧麗;邱茜茜;范波勝;;高血壓性腦出血后遲發(fā)性腦水腫10例臨床分析[J];中國(guó)實(shí)用神經(jīng)疾病雜志;2010年20期

5 劉夢(mèng);;腦\，

本文編號(hào)：1894212