本文選題：強(qiáng)直性脊柱炎 + Th細(xì)胞　； 參考：《現(xiàn)代免疫學(xué)》2016年01期

【摘要】：在強(qiáng)制性脊柱炎(ankylosing spondylitis,AS)發(fā)病機(jī)制的諸多假設(shè)中,免疫細(xì)胞格局失調(diào)被認(rèn)為是一個(gè)重要機(jī)制。Th17細(xì)胞和Treg細(xì)胞是CD4+T細(xì)胞的兩個(gè)亞群,對(duì)炎癥分別起著促進(jìn)和抑制的作用。諸多研究提示,Th17細(xì)胞和Treg細(xì)胞數(shù)量及相關(guān)細(xì)胞因子在AS患者外周血中與健康者有差別,其比例失衡在AS的發(fā)展中有重要作用,具體機(jī)制仍不清楚。本文介紹了近年來Th17和Treg細(xì)胞及其比例失衡在AS發(fā)展中作用的研究進(jìn)展。
[Abstract]:In many hypotheses of the pathogenesis of mandatory spondylitis, immune cell pattern disorder is considered to be an important mechanism. Th17 cells and Treg cells are two subsets of CD4 T cells, which play a role in promoting and inhibiting inflammation, respectively. Many studies suggest that the number of Th17 cells and Treg cells and related cytokines are different in the peripheral blood of as patients, and the imbalance of the ratio of Th17 cells and Treg cells plays an important role in the development of as, and the specific mechanism is still unclear. In this paper, the research progress of Th17 and Treg cells and their proportion imbalance in the development of as are reviewed.
【作者單位】： 上海交通大學(xué)醫(yī)學(xué)院免疫與微生物系;
【基金】：上海市科委基礎(chǔ)研發(fā)重點(diǎn)項(xiàng)目(11JC1411602) 上海市教委科研創(chuàng)新重點(diǎn)項(xiàng)目(12ZZ1103) 國家自然科學(xué)基金(81373208) 上海交通大學(xué)醫(yī)學(xué)院2013級(jí)PBL項(xiàng)目
【分類號(hào)】：R593.23

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