本文選題：睡眠時間 + 糖調(diào)節(jié)受損　； 參考：《蘭州大學(xué)》2017年碩士論文

【摘要】：目的分析人群睡眠時間狀況和糖代謝情況,并探討睡眠時間與糖代謝的相關(guān)性。方法利用“Reaction”研究甘肅地區(qū)資料,抽取蘭州市社區(qū)40~75歲符合條件的居民共8526例進行研究。提取性別、年齡、入睡時間、起床時間、睡眠狀況、打鼾情況、獨居情況、職業(yè)狀態(tài),測量身高、體重、腰圍(WC)、臀圍(HC)、收縮壓(SBP)、舒張壓(DBP),檢測空腹血糖(FBG)、負荷后2小時血糖(2hPG)、糖化血紅蛋白(HbA1c)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)、甘油三酯(TG)、總膽固醇(TC)等。按夜間睡眠時間5小時(h)、~6h、~7h、~8h、~9h、9h將研究人群共分為6組。統(tǒng)計并分析該人群的睡眠時間狀況,并探討不同睡眠時間分組與正常糖耐量(NGT)、糖調(diào)節(jié)受損(IGR)、糖尿病(DM)之間的相關(guān)性。結(jié)果(1)8526例研究對象中,男性2446例(28.7%)、女性6080例(71.3%)。平均年齡(57.5±8.4)歲,平均體質(zhì)量指數(shù)(BMI)為(24.1±3.2)kg/m2。平均睡眠時間為(7.62±1.16)h,男女睡眠時間無顯著性差異(P0.05)。研究人群的IGR、DM患病率分別為28.1%、23.9%,男性DM的患病率高于女性(31.5%vs 20.9%,P0.05)。(2)睡眠時間5h組、~6h組、~7h組、~8h組、~9h組、9h組中的人群平均睡眠時間分別為(3.54±0.92)h、(5.75±0.40)h、(6.85±0.28)h、(7.79±0.32)h、(8.67±0.35)h、(9.89±0.88)h。各組分別占總?cè)巳罕壤謩e為1.3%、19.1%、23.6%、39.6%、21.1%、5.2%。(3)單因素方差分析表明,不同睡眠時間下FBG、HbA1c、HDL、LDL、TC均有顯著性(P均0.05)。將睡眠時間~8h設(shè)為參照組,睡眠時間5h的FBG、HbA1C水平較參照組高(P均0.05)。HDL-C、TC均在睡眠時間~9h偏低和睡眠時間~6h偏高(P均0.05)。與參照組相比,睡眠時間~9h時BMI水平偏低(P0.05)。(4)在研究對象中,NGT、IGR、DM者所占百分比分別是47.9%、28.1%、23.9%,52%研究對象患有糖代謝異常。總的來說,糖代謝異常人群的年齡偏大,血糖水平(FBG、2hPG、Hb A1c)、血脂水平(LDL、TG、TC)、BMI、WC、SBP和DBP均偏高(P均0.05)。(5)睡眠時間5h組的DM的患病率較其它睡眠時間組偏高(P0.05)。不同睡眠時間分組下,IGR患病率無顯著性差異(P均0.05)。不同睡眠時間分組下男女IGR、DM患病率無顯著性差異(P0.05)。(6)Logistic回歸分析顯示:將睡眠時間~8h設(shè)為參照組,DM、IGR患病率設(shè)為因變量,未調(diào)整混雜因素時,睡眠時間5h可增加DM、男性IGR的患病風(fēng)險。在上述基礎(chǔ)上,調(diào)整年齡、性別、WC、HDL-C、LDL-C、TG、TC、睡眠情況、打鼾史、文化程度、職業(yè)狀態(tài)、獨居情況、體力活動、高血壓、血脂異常、糖尿病家族史、飲酒史及吸煙史因素后,睡眠時間5h仍可以增加DM、男性IGR的患病風(fēng)險。進一步調(diào)整BMI因素,上述相關(guān)性仍存在統(tǒng)計學(xué)差異。結(jié)論睡眠時間5h與男性IGR的患病風(fēng)險呈正相關(guān),睡眠時間5h是男性IGR的獨立危險因素。睡眠時間5h與DM的患病風(fēng)險呈正相關(guān),睡眠時間5h是DM的獨立危險因素。
[Abstract]:Objective to investigate the relationship between sleep time and glucose metabolism. Methods A total of 8526 eligible residents aged 4075 years in the community of Lanzhou City were studied by "Reaction". Sex, age, time to fall asleep, time to get up, sleep status, snoring, solitude, professional status, measurement of height, weight, WCU, HCG, SBP, DBP, FBGG, 2hPGN, HbA1cn, HDL-CU, LDL-CGN, TGN, TGN, TGN, TGN, TBGG, HbA1cU, HDL-CU, LDL-CU, TGN, TGN, TGG, et al in waist circumference, hip circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBGG), 2hPGN after loading, HbA1cn, HDL-CU, LDL-CU, TGN, TCC, et al. The study group was divided into 6 groups according to the sleep time of 5 hours at night, 6 hours, 7 hours, 8 hours, 9 hours and 9 hours. The sleep time status of this population was statistically analyzed and the correlation between different sleep time groups and normal glucose tolerance (NGT), impaired glucose regulation (IGR) and diabetes mellitus (DM) was discussed. Results among 8526 subjects, 2446 cases were male and 6080 cases were female. The mean age was 57.5 鹵8.4 years, and the mean body mass index (BMI) was 24.1 鹵3.2kg 路kg / m ~ (2). The average sleep time was 7.62 鹵1.16h. there was no significant difference in sleep time between male and female (P 0.05). The prevalence rate of IGRN DM in the study population was 28.1and 23.9.The prevalence rate of DM in males was higher than that in females (31.5 vs 20.9). The average sleep time was 8.67 鹵0.35hmh in 5h group, 7h group in 7h group and 7h group in 8h group. The average sleep time in 9h group was 3.54 鹵0.92hU (5.75 鹵0.40hmh) 7.79 鹵0.32hmh (8.67 鹵0.35hmh). The ratio of each group to the total population was 1.3and 19.1and 23.6cm, respectively. The single factor analysis of variance showed that there were significant differences in LDLTC between HbA1C and HDLLDLTc under different sleep time (P < 0.05). The HbA1C level of the 5h sleep time group was higher than that of the control group (P < 0.05). HDL-CU TC was lower than that of the control group during sleep time of 9 hours and the sleep time of 6 hours was higher than that of the control group (P < 0.05). Compared with the control group, the percentage of patients with NGT IGR DM was 47.9% and 28.1g / 23.9% of the subjects had abnormal glucose metabolism. In general, the age of people with abnormal glucose metabolism was higher than that of other sleep time groups. The prevalence of DM in patients with abnormal glucose level was higher than that in other sleep time groups (P < 0.05), and the blood glucose level was higher than that in other sleep time groups (P < 0.05). There was no significant difference in the prevalence of IGR among different sleep time groups (P < 0.05). There was no significant difference in the prevalence rate of IGR between men and women under different sleep time groups. Logistic regression analysis showed that the prevalence rate of IGR in the control group was set as dependent variable when the sleep time was 8 hours, and the risk of IGR was increased when the sleep time was not adjusted for 5 hours. On the above basis, after adjusting for age, sex, HDL-C, LDL-C, sleep, history of snoring, education, occupational status, living alone, physical activity, hypertension, dyslipidemia, family history of diabetes, history of drinking and smoking, Sleeping for 5 hours still increased the risk of IGR in men. Further adjustment of BMI factors, the above correlation still exist statistical difference. Conclusion 5 h sleep time is positively correlated with the risk of IGR in men, and 5 h sleep time is an independent risk factor for male IGR. 5 h sleep time was positively correlated with the risk of DM, and 5 h sleep time was an independent risk factor for DM.
【學(xué)位授予單位】：蘭州大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R587.1

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