本文選題：糖尿病 + 糖尿病腎病��； 參考：《中國組織工程研究》2016年05期

【摘要】：背景:研究發(fā)現(xiàn)β-酪啡肽7有對(duì)糖尿病模型大鼠減輕腎小管上皮細(xì)胞的氧化及降血糖的作用,但關(guān)于β-酪啡肽7對(duì)糖尿病腎病作用機(jī)制的研究比較少。目的:探討β-酪啡肽7對(duì)糖尿病腎病模型大鼠腎損傷的作用。方法:將30只大鼠隨機(jī)以n=10等分為對(duì)照組、模型組和β-酪啡肽7組。構(gòu)建糖尿病模型大鼠20只,造模成功后模型組和β-酪啡肽7組模型大鼠腹腔注射鏈脲佐菌素(60 mg/kg),對(duì)照組腹腔注射等量檸檬酸液,β-酪啡肽7組模型大鼠給予β-酪啡肽7灌胃30 d,模型組和對(duì)照組給予等量生理鹽水灌胃。結(jié)果與結(jié)論:1與對(duì)照組相比,模型組大鼠胰島素水平降低,血糖、尿糖、尿蛋白、血清肌酐、血清尿素氮水平以及腎臟中Ⅰ型膠原蛋白和Ⅳ型膠原蛋白的mRNA和蛋白表達(dá)水平增加。2與模型組相比,β-酪啡肽7組模型大鼠上述指標(biāo)明顯恢復(fù)。表明β-酪啡肽7對(duì)糖尿病腎病模型大鼠腎損傷有保護(hù)作用。
[Abstract]:Background: it has been found that 尾 -tyrophin 7 can reduce the oxidation and hypoglycemia of renal tubular epithelial cells in diabetic rats, but the mechanism of 尾 -tyroenkephalin 7 on diabetic nephropathy is less studied. Objective: to investigate the effect of 尾 -tyrophin 7 on renal injury in diabetic nephropathy rats. Methods: thirty rats were randomly divided into control group (n = 10) and 尾 -tyrophin group (n = 7). Twenty diabetic rats were established. The model group and 尾 -tyroenkephalin group were injected intraperitoneally with streptozotocin 60 mg / kg, the control group with citric acid solution and 尾 -tyroenkephalin 7 group with 尾 -tyroenkephalin 7 intragastrically for 30 days. The model group and control group were given intraperitoneal administration of 尾 -tyroenkephalin 7 for 30 days. Group A was given the same amount of normal saline intragastric perfusion. Results compared with the control group, the insulin level, blood glucose, urine sugar, urine protein, serum creatinine and serum creatinine were decreased in the model group. Compared with the model group, the levels of serum urea nitrogen and the expression of mRNA and protein of type 鈪，

本文編號(hào)：1856169