本文選題：獲得性免疫缺陷綜合征 + 人類(lèi)免疫缺陷病毒��； 參考：《中國(guó)感染控制雜志》2017年09期

【摘要】：目的探討血清趨化因子(RANTES)、單核細(xì)胞趨化蛋白1(MCP-1)、基質(zhì)細(xì)胞衍生因子-1β(SDF-1β)在獲得性免疫缺陷綜合征(AIDS)和正常人體內(nèi)的差異。方法選擇2010年1月—2015年1月某院收集的38例AIDS患者作為AIDS組,38例健康者作為健康組,檢測(cè)兩組血清RANTES、MCP-1、SDF-1β水平,并根據(jù)病毒載量進(jìn)行亞組分析。結(jié)果 AIDS組患者血清中RANTES、MCP-1、SDF-1β水平分別為(1 392.55±227.69)、(450.91±103.04)、(104.82±22.52)pg/mL,均高于健康組[分別為(120.58±55.87)、(74.25±33.62)、(39.04±11.43)pg/mL],差異均具有統(tǒng)計(jì)學(xué)意義(均P0.05)。HIV病毒載量4≤Log(VL)5、Log(VL)≥5的AIDS患者血清中RANTES水平分別為(1 470.34±155.01)、(1 408.29±181.54)pg/mL,均高于Log(VL)4組患者[(1 183.12±174.54)pg/mL];HIV病毒載量4≤Log(VL)5的AIDS患者血清中MCP-1、SDF-1β水分別為(537.93±89.32)、(149.31±18.05)pg/mL,高于Log(VL)≥5組[分別為(410.26±80.57)、(81.53±20.31)pg/mL]和Log(VL)4組患者[分別為(381.71±77.26)、(72.90±21.62)pg/mL],差異均有統(tǒng)計(jì)學(xué)意義(均P0.05)。結(jié)論 AIDS患者血清RANTES、MCP-1、SDF-1β水平顯著升高,且與病毒載量水平有一定的關(guān)系。
[Abstract]:Objective to investigate the difference of serum chemokine RANTES1, monocyte chemoattractant protein 1 (MCP-1P) and stromal cell derived factor 1 尾 (SDF-1 尾) in acquired immunodeficiency syndrome (AIDS) and normal volunteers. Methods 38 patients with AIDS collected from January 2010 to January 2015 were selected as AIDS group and 38 healthy persons as healthy group. The serum levels of RANTES MCP-1and SDF-1 尾 were detected and subgroup analysis was performed according to the viral load. 緇撴灉 AIDS緇勬?zhèn)ｈ�呰娓呬腑RANTES,MCP-1,SDF-1尾姘村鉤鍒嗗埆涓，

本文編號(hào)：1854388