本文選題：中青年 + 糖尿病�。� 參考：《延邊大學(xué)》2017年碩士論文

【摘要】：目的:分析中青年糖尿病合并頸動(dòng)脈斑塊形成的相關(guān)危險(xiǎn)因素,為有效干預(yù)中青年糖尿病大血管并發(fā)癥的發(fā)生、發(fā)展提供臨床依據(jù)。對(duì)象及方法:選擇2014年1月至2016年9月,在延邊大學(xué)附屬醫(yī)院健康體檢中心體檢并行頸動(dòng)脈彩超的18-60歲中青年糖尿病人群按頸動(dòng)脈彩超結(jié)果,分為CAP組(IMT≥1.5mm),共202例和非CAP組(IMT1.5mm),共200例及健康組174例。每一受試者記錄身高、體重、血壓和空腹血糖、血脂、尿酸等進(jìn)行測(cè)量和分析。結(jié)果:1.糖尿病組頸動(dòng)脈斑塊形成顯著高于健康組,且不同年齡段間高齡段頸動(dòng)脈斑塊增加,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。3.糖尿病組的一般資料及生化指標(biāo)均高于健康組,差異有統(tǒng)計(jì)學(xué)意義(P0.01);糖尿病組亞組,CAP組與非CAP組間總膽固醇、低密度脂蛋白、空腹血糖、收縮壓及糖尿病病史有明顯差異(P0.05)。4.糖尿病合并頸動(dòng)脈斑塊形成男性與女性間有明顯差異(P0.01);吸煙年限≤15年和吸煙年限15年間頸動(dòng)脈斑塊形成差異有統(tǒng)計(jì)學(xué)意義(P0.01)。5.Logistic回歸分析結(jié)果示,校正了其他因素之后,低密度脂蛋白、收縮壓、空腹血糖、糖尿病病史及吸煙年限是糖尿病合并頸動(dòng)脈斑塊形成的獨(dú)立危險(xiǎn)因素(0R 1.804,95%CI(1.304-2.496),P0.01;0R 1.022,95%CI(1.010-1.033),P0.01;OR 1.169,95%CI(1.054-1.297),P0.05;OR 1.174,95%CI(1.096-1.252),P0.01;OR 1.190,95%CI(1.101-1.278),P0.01))。結(jié)論:1.糖尿病患者FBG及糖尿病病史是頸動(dòng)脈斑塊形成重要的危險(xiǎn)因素之一。2.高齡、SBP、TC、LDL-C、超重及吸煙年限等,也可顯著影響中青年糖尿病合并頸動(dòng)脈斑塊的形成。3.男性中青年糖尿病患者頸動(dòng)脈斑塊形成風(fēng)險(xiǎn)高于女性。
[Abstract]:Objective: to analyze the risk factors related to the formation of carotid plaque in young and middle-aged diabetes mellitus, and to provide clinical basis for effective intervention on the occurrence and development of macrovascular complications in young and middle-aged diabetes mellitus. Participants and methods: from January 2014 to September 2016, a group of young and middle-aged diabetic subjects aged 18-60 years with diabetes mellitus aged 18-60 years were examined by carotid artery color Doppler ultrasound at the Health examination Center of Yanbian University affiliated Hospital. The patients were divided into two groups: CAP group (n = 202) and non CAP group (n = 200) and healthy group (n = 174). Height, weight, blood pressure and fasting blood glucose, blood lipids, uric acid were measured and analyzed. The result is 1: 1. Carotid plaque formation in diabetic group was significantly higher than that in healthy group, and carotid plaque in elderly patients increased in different age groups, and the difference was statistically significant (P 0.05. 3). The general data and biochemical indexes of diabetic group were higher than that of healthy group, the difference was statistically significant (P 0.01), and there were significant differences in total cholesterol, low density lipoprotein, fasting blood glucose, systolic blood pressure and history of diabetes mellitus between CAP group and non CAP group. There was a significant difference between male and female in the formation of carotid plaque in diabetes mellitus (DM), and significant difference in plaque formation in carotid artery between male and female during the period of smoking 鈮，

本文編號(hào)：1818440